Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Craig Swearingen"'
Autor:
Jeffery N. Carroll, Craig Swearingen, Decrescenzo Gary A, Rico Joseph G, Theresa R. Fletcher, Daniel P. Becker, Joseph J. McDonald, Susan L. Hockerman, Grace E. Munie, Stephen A. Kolodziej, Boehm Terri L, Debbie A. Mischke, Nathan W. Stehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3557-3560
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61c5bde65513f60ea0896cfb24e7ec
https://doi.org/10.1016/j.bmcl.2010.04.130
https://doi.org/10.1016/j.bmcl.2010.04.130
Autor:
Daniel P. Becker, Theresa R. Fletcher, Debbie A. Mischke, Joseph J. McDonald, Stephen A. Kolodziej, Nathan W. Stehle, Susan L. Hockerman, Grace E. Munie, Craig Swearingen, Decrescenzo Gary A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3561-3564
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95e2ec754d4d05a448abe4797fbdd4
https://doi.org/10.1016/j.bmcl.2010.04.111
https://doi.org/10.1016/j.bmcl.2010.04.111
Autor:
Robert W. Karr, Christine P. Bono, D.A. Kirschmann, Michelle L. Zacheis, Benjamin D. Schwartz, Troy A. Baudino, Craig Swearingen, Susan L. Woulfe
Publikováno v:
Arthritis & Rheumatism. 38:1744-1753
Objective. To identify critical residues involved in the binding of a selective peptide to DRB1*0401. Methods. The binding of peptides to native or site-directed mutant DR molecules was evaluated using enzyme-linked immunosorbent assay and flow cytom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b526af1d513e5c53e9ab9c2614de2ae8
https://doi.org/10.1002/art.1780381207
https://doi.org/10.1002/art.1780381207
Autor:
John N. Freskos, Craig Swearingen, Getman Daniel P, Pramod P. Mehta, Grace E. Munie, Daniel P. Becker, Susan L. Hockerman, Madeleine Li, Decrescenzo Gary A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2723-2725
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1532a87d600b0673f0ba421e0a7e689c
https://doi.org/10.1016/s0960-894x(01)00557-1
https://doi.org/10.1016/s0960-894x(01)00557-1
Autor:
Chris P. Carron, Madeleine H. Li, Daniel P. Becker, T. Sunyer, John N. Freskos, Louis J. Bedell, Boehm Terri L, Chris L. Funckes-Shippy, Decrescenzo Gary A, Clara I. Villamil, Joseph J. McDonald, Grace E. Munie, Jeffery N. Carroll, Pramod P. Mehta, Jun Yao, Brian R. Bond, Craig Swearingen, Jennifer M. Williams, Barta Thomas E, Marcia I. Heron, Dean Welsch, Karl J. Mathis, Carol Pearcy Howard, James R. Kiefer, Susan L. Hockerman, Alan M. Easton, Ying Yu
Publikováno v:
Journal of medicinal chemistry. 53(18)
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9685357a0ce79c92aebc66064d268699
https://pubmed.ncbi.nlm.nih.gov/20726512
https://pubmed.ncbi.nlm.nih.gov/20726512
Autor:
Susan L. Hockerman, Pramod P. Mehta, John N. Freskos, Daniel P. Becker, Getman Daniel P, Craig Swearingen, Grace E. Munie, Decrescenzo Gary A, Madeleine Li
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed804aa2855b42414bafce6ab387e4f
https://doi.org/10.1002/chin.200204200
https://doi.org/10.1002/chin.200204200
Autor:
Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A
Publikováno v:
Journal of medicinal chemistry. 48(21)
alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539500154a05a00e3a097afebbcc7a1
https://pubmed.ncbi.nlm.nih.gov/16220987
https://pubmed.ncbi.nlm.nih.gov/16220987
Autor:
Dean Welsch, Craig Swearingen, Getman Daniel P, Joseph J. McDonald, Nandini Kishore, Shaukat H. Rangwala, Decrescenzo Gary A, Mischke Brent, Susan C. Howard, Grace E. Munie, Heintz Robert M, Charles Voliva, John N. Freskos
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(7)
We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5e8490b5ac796c34d5a1450833ae40
https://pubmed.ncbi.nlm.nih.gov/10230616
https://pubmed.ncbi.nlm.nih.gov/10230616
Autor:
Craig Swearingen, Francesco Sinigaglia, Robert W. Karr, Alessandro Sette, Neena L. Summers, Xin-Ting Fu, Benjamin D. Schwartz, Susan L. Woulfe, Chris P. Bono
Publikováno v:
The Journal of Experimental Medicine
To investigate the functional roles of individual HLA-DR residues in T cell recognition, transfectants expressing wild-type or mutant DR(alpha,beta 1*0401) molecules with single amino acid substitutions at 14 polymorphic positions of the DR beta 1*04
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59813eef1e4f9f30bcdd0888b7a0757d
https://pubmed.ncbi.nlm.nih.gov/7869051
https://pubmed.ncbi.nlm.nih.gov/7869051
Autor:
Mack, Justin K, Bivi, Nicoletta
Publikováno v:
Bioanalysis; Oct2023, Vol. 15 Issue 19, p1179-1191, 13p