Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

Autor: Austin Smith, Ian Chambers, Craig Stracey, Tom Burdon, Hitoshi Niwa

Publikováno v: Cells, tissues, organs. 165(3-4)

An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0416e53f37698001f2558ea39563cb4e
https://pubmed.ncbi.nlm.nih.gov/10592385

Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells

Autor: Craig Stracey, Jennifer Nichols, Austin Smith, Ian Chambers, Tom Burdon

Publikováno v: Burdon, T, Stracey, C, Chambers, I, Nichols, J & Smith, A 1999, ' Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells ', Developmental Biology, vol. 210, no. 1, pp. 30-43 . https://doi.org/10.1006/dbio.1999.9265

The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals transduced through the cytokine receptor subunit gp130. Signalling molecules activated downstream of gp130 in ES cells include STAT3, the protein tyrosine phosphatase S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf939acec299ee2f785f49614175525d