Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Craig S. Gibbs"'
Publikováno v:
Antiviral Therapy. 17:993-999
Background The selection of antiretroviral (ARV) drugs for treatment of HIV-1 infection is based on several factors including potency, toxicity, resistance and ease of administration. Emtricitabine (FTC) or lamivudine (3TC), components of recommended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565f961f008889232c5faac1b59a848b
https://doi.org/10.3851/imp2266
https://doi.org/10.3851/imp2266
Autor:
Karsten Wursthorn, Christian Trepo, William E. Delaney, Stephen Locarnini, Patrick Marcellin, Jörg Petersen, Scott Bowden, Fabien Zoulim, Shan-Shan Chen, Craig S. Gibbs, Carol L. Brosgart, Shelly Xiong, Zachary Goodman, George K. K. Lau, Bettina Werle-Lapostolle
Publikováno v:
Gastroenterology. 126:1750-1758
BACKGROUND & AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aad0ed79175e6afb8982cd532c483e5
https://doi.org/10.1053/j.gastro.2004.03.018
https://doi.org/10.1053/j.gastro.2004.03.018
Publikováno v:
Journal of Biological Chemistry. 279:26387-26394
Thrombin is the ultimate protease of the blood clotting cascade and plays a major role in its own regulation. The ability of thrombin to exhibit both pro- and anti-coagulant properties has spawned efforts to turn thrombin into an anticoagulant for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e9a769a9e437e51042b9f39fdd5253
https://doi.org/10.1074/jbc.m402364200
https://doi.org/10.1074/jbc.m402364200
Autor:
Christopher Westland, Shelly Xiong, Eddy Arnold, Huiling Yang, Michael D. Miller, Kalyan Das, Craig S. Gibbs, William E. Delaney
Publikováno v:
Journal of Virology. 77:11833-11841
Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif (reverse transcriptase [rt] mutations rtM204V/I) confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a031ae1abc7e8d202f2fb887a4bda
https://doi.org/10.1128/jvi.77.21.11833-11841.2003
https://doi.org/10.1128/jvi.77.21.11833-11841.2003
Autor:
Shelly Xiong, Danielle Colledge, Huiling Yang, Angeline Bartholomeusz, Craig S. Gibbs, Stephen Locarnini, Carol L. Brosgart, Peter W Angus, Rhys Vaughan, Anna Ayres, William E. Delaney, Rosalind Edwards
Publikováno v:
Gastroenterology. 125:292-297
Background & aims: Adefovir dipivoxil effectively inhibits both hepatitis B virus (HBV) replication and disease activity in patients with chronic hepatitis B. Resistance to treatment was not observed in 2 recent large placebo-controlled 48-week studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607d6e7d81b8eb1b1a14ff9e0d807673
https://doi.org/10.1016/s0016-5085(03)00939-9
https://doi.org/10.1016/s0016-5085(03)00939-9
Autor:
Huiling Yang, Shelly Xiong, Shan-Shan Chen, Craig S. Gibbs, Carol L. Brosgart, Stephanos J. Hadziyannis, William E. Delaney, Patrick Marcellin, Chris Westland, John Fry, Michael D. Miller, Robert G. Gish
Publikováno v:
Gastroenterology. 125:107-116
Background & aims: Hepatitis B virus (HBV) genotype may influence disease progression and antiviral response. We therefore analyzed the frequency and distribution of genotypes in patients from 2 multinational phase III studies of adefovir dipivoxil.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04307dd0ec4fae9f3fc6f4b5a1cd6d17
https://doi.org/10.1016/s0016-5085(03)00700-5
https://doi.org/10.1016/s0016-5085(03)00700-5
Autor:
John Fry, Craig S. Gibbs, Carol L. Brosgart, William E. Delaney, Huiling Yang, Michael D. Miller, Shelly Xiong, Michael Wulfsohn, Christopher Westland
Publikováno v:
Hepatology. 38:96-103
Seven hundred nucleoside treatment-naive patients were enrolled in two phase 3 trials of adefovir dipivoxil (ADV) for the treatment of chronic hepatitis B. To monitor for the emergence of potential adefovir resistance mutations over the first 48 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133f6f882cb1499dde9b92949e199e00
https://doi.org/10.1053/jhep.2003.50288
https://doi.org/10.1053/jhep.2003.50288
Publikováno v:
Journal of Viral Hepatitis. 10:50-54
summary. Adefovir is a potent nucleotide analog inhibitor of hepatitis B virus (HBV) DNA polymerase. Its oral prodrug adefovir dipivoxil has been approved for the treatment of chronic HBV infection. In this study, adefovir was characterized for its i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5277e7d1566fe183e91a8744b2d359
https://doi.org/10.1046/j.1365-2893.2003.00399.x
https://doi.org/10.1046/j.1365-2893.2003.00399.x
Publikováno v:
Antiviral Research. 56:99-114
Human rhinoviruses (HRV) represent the single most important causative agent of the common cold. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) designated 3D polymerase that is required for replication of the HRV RNA genome. We have ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3e0f50ebedb92de3d575fdc3e99b85
https://doi.org/10.1016/s0166-3542(02)00101-8
https://doi.org/10.1016/s0166-3542(02)00101-8
Autor:
Craig S. Gibbs, Carol L. Brosgart, Elizabeth J. Heathcote, Christopher Westland, Victoria Ho, William E. Delaney, John Fry, Michael D. Miller, Shelly Xiong, Huiling Yang
Publikováno v:
Hepatology. 36:464-473
Current therapies for chronic hepatitis B virus (HBV) infection do not provide adequate long-term control of viral replication in the majority of patients. Monotherapy with nucleoside analogs, such as lamivudine and famciclovir, is effective for shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81ac44415bcfc86389f56dca7b3744b4
https://doi.org/10.1053/jhep.2002.34740
https://doi.org/10.1053/jhep.2002.34740