Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Craig Rowlands"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127952 (2015)
A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and subsequent binding the activated AHR to xenobiotic response elements
Externí odkaz:
https://doaj.org/article/8575df5f2d804c5389c56fe8817d65b7
Autor:
Tyler Peryea, Ahsan Habib Polash, Alessandra Roncaglioni, Daniel M. Wilson, Warren Casey, Patricia Ruiz, Nathalie Alépée, Sherif Farag, Giovanna J. Lavado, Kimberley M. Zorn, Alexey V. Zakharov, Davide Ballabio, Katrina M. Waters, Risa Sayre, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nicole Kleinstreuer, Pankaj R. Daga, Sean Ekins, Kamel Mansouri, Liguo Wang, Judy Strickland, Matthew J. Hirn, Sudin Bhattacharya, Dac-Trung Nguyen, Emilio Benfenati, Ignacio J. Tripodi, Amanda K. Parks, Garett Goh, Dennis G. Thomas, Glenn J. Myatt, Prachi Pradeep, Gergely Zahoranszky-Kohalmi, Anton Simeonov, Arthur C. Silva, Grace Patlewicz, Timothy Sheils, Stephen Boyd, Agnes L. Karmaus, Ahmed Sayed, Alex M. Clark, Todd M. Martin, Pavel Karpov, Jeffery M. Gearhart, Robert Rallo, D Allen, Charles Siegel, Zhen Zhang, Zijun Xiao, Alexander Tropsha, Stephen J. Capuzzi, Alexandru Korotcov, Carolina Horta Andrade, Noel Southall, Viviana Consonni, Igor V. Tetko, Jeremy M. Fitzpatrick, Andrew J. Wedlake, Denis Fourches, Zhongyu Wang, Vinicius M. Alves, Eugene N. Muratov, Timothy E. H. Allen, Andrea Mauri, James B. Brown, Alexandre Varnek, Yun Tang, Sanjeeva J. Wijeyesakere, Daniel P. Russo, Cosimo Toma, Christopher M. Grulke, Michael S. Lawless, Domenico Gadaleta, Paritosh Pande, Thomas Hartung, Jonathan M. Goodman, Kristijan Vukovic, Joyce V. Bastos, Daniela Trisciuzzi, Fagen F. Zhang, Domenico Alberga, Thomas Luechtefeld, Dan Marsh, Tyler R. Auernhammer, Shannon M. Bell, Xinhao Li, Brian J. Teppen, F. Lunghini, Sergey Sosnin, Hao Zhu, Feng Gao, Craig Rowlands, Tongan Zhao, R Todeschini, Valery Tkachenko, Francesca Grisoni, Hongbin Yang, Yaroslav Chushak, Maxim V. Fedorov, Heather L. Ciallella, Gilles Marcou
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10be9a3f401d14e1b5653e1242ab66
https://www.repository.cam.ac.uk/handle/1810/322114
https://www.repository.cam.ac.uk/handle/1810/322114
Autor:
Donna L. Mendrick, Elizabeth A. Maull, J. Craig Rowlands, David Allen, Stephen W. Edwards, Warren Casey, Michelle R. Embry, Joanna Matheson, Kristie Sullivan, Nicole Kleinstreuer, Sharon Munn
Publikováno v:
Regulatory Toxicology and Pharmacology. 76:39-50
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproduct
Publikováno v:
Toxicological Sciences
Earlier we created a chemical hazard database via natural language processing of dossiers submitted to the European Chemical Agency with approximately 10 000 chemicals. We identified repeat OECD guideline tests to establish reproducibility of acute o
Autor:
J. Craig Rowlands, Abraham Nyska, Robert A. Budinsky, Greg D. Martin, Marie Lawson, Russell S. Thomas, Renee R. Hukkanen, Debra K. Layko, Rosa Anna Manno, Andrea Grassetti, Joshua A. Harrill
Publikováno v:
Journal of Applied Toxicology. 36:802-814
Sustained activation of the aryl hydrocarbon receptor (AHR) is believed to be the initial key event in AHR receptor-mediated tumorigenesis in the rat liver. The role of AHR in mediating pathological changes in the liver prior to tumor formation was i
Autor:
Lola M. Reid, Russell S. Thomas, J. Craig Rowlands, Eliane Wauthier, Bethany Parks, Joshua A. Harrill
Publikováno v:
Hepatology (Baltimore, Md.)
Rodent cancer bioassays indicate that the aryl hydrocarbon receptor (AHR) agonist, 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD), causes increases in both hepatocytic and cholangiocytic tumors. Effects of AHR activation have been evaluated on rodent he
Autor:
Grace Patlewicz, Louis Anthony Cox, J. Craig Rowlands, Richard A. Becker, M. Sue Marty, Katy O. Goyak, Douglas A. Popken
Publikováno v:
Regulatory Toxicology and Pharmacology. 69(3):443-450
High throughput (HTS) and high content (HCS) screening methods show great promise in changing how hazard and risk assessments are undertaken, but scientific confidence in such methods and associated prediction models needs to be established prior to
Autor:
A. Aziz Aboobaker, J. Craig Rowlands, Simon V. Avery, David R. Bell, Martin Rose, Sunir Malla, Abeer H. A. Amer, Richard J. Wall, Ian R. Mellor, Fei Sang, Timothy W. Gant
Publikováno v:
Toxicol. Res.. 3:315-323
The mechanisms regulating the induction of hepatic DNA synthesis by PPARα agonists are currently incompletely understood, and we set out to determine whether there are different mechanisms of induction for PPARα agonists and other hepatic growth ag
Autor:
Alan A. Dombkowski, Michael B. Black, J. Craig Rowlands, Robert A. Budinsky, Daniela Cukovic, Russell D. Wolfinger, Russell S. Thomas, Chad M. Thompson, B. Bhaskar Gollapudi, Jonathan D. Urban
Publikováno v:
Toxicological Sciences. 136:595-604
Toxic equivalency factors (TEFs) for dioxin-like compounds are largely based on relative potency (REP) values derived from biochemical endpoints such as enzyme activity. As of yet, REPs based on gene expression changes have not been accounted for in
Autor:
Shawna D’Ingillo, Russell S. Thomas, Natalia Kovalova, Anthony Bach, Joshua A. Harrill, Jinpeng Li, J. Craig Rowlands, Norbert E. Kaminski, Ashwini S. Phadnis-Moghe, Jose E. Suarez-Martinez, Robert A. Budinsky, Robert B. Crawford, Weimin Chen, Barbara L. F. Kaplan
Publikováno v:
Toxicology.
The aryl hydrocarbon receptor (AHR) has been extensively characterized for the essential role it plays in mediating the toxic responses elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Despite similarities across animal species, species-specif