Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Craig R. Schneider"'
Autor:
Ning Qin, Michael F.A. Finley, Christopher M. Flores, Michael P. Neeper, Michael P. Winters, Michael R. Brandt, Wall Mark, Nalin L. Subasinghe, Raymond W. Colburn, Zhihua Sui, Craig R. Schneider, Mary Lou Lubin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3780-3783
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay.
Autor:
Edward S Kimball, Nathaniel K Wallace, Craig R Schneider, Michael R D'Andrea, Pamela J Hornby
Publikováno v:
Frontiers in Pharmacology, Vol 1 (2010)
Cannabinoids are known to be clinically beneficial for control of appetite disorders and nausea/vomiting, with emerging data that they can impact other GI disorders, such as inflammation. Post-inflammatory irritable bowel syndrome (PI-IBS) is a condi
Externí odkaz:
https://doaj.org/article/66aa94fe1daa48fcbf1ce536a1f44816
Autor:
Mark J, Wall, Nalin L, Subasinghe, Michael P, Winters, Mary Lou, Lubin, Michael F A, Finley, Ning, Qin, Michael R, Brandt, Michael P, Neeper, Craig R, Schneider, Raymond W, Colburn, Christopher M, Flores, Zhihua, Sui
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(23-24)
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay.
Autor:
Michael R. Brandt, Michael F.A. Finley, Ning Qin, Michael P. Winters, Craig R. Schneider, Mary Lou Lubin, Michael P. Neeper, Nalin L. Subasinghe, Zhihua Sui, Raymond W. Colburn, Christopher M. Flores, Wall Mark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4080-4083
Selective blockers of the N-type calcium channel have proven to be effective in animal models of chronic pain. However, even though intrathecally delivered synthetic ω-conotoxin MVIIA from Conus magnus (ziconotide [Prialt®]) has been approved for t
Autor:
Shelley K. Ballentine, Mark R. Player, Mary Lou Lubin, Raul R. Calvo, Craig R. Schneider, William H. Parsons, Raymond W. Colburn, Parks Daniel J, Sanath K. Meegalla, Christopher M. Flores
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1903-1907
Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 291:G364-G371
Oil of mustard (OM) is a potent neuronal activator that is known to elicit visceral hyperalgesia when given intracolonically, but the full extent to which OM is also proinflammatory in the gastrointestinal tract is not known. We have previously shown
Autor:
Pamela J. Hornby, Bruce P. Damiano, Alexey B. Dyatkin, N. H. Wallace, M. Carolyn Fisher, Stephen M. Prouty, Bruce E. Maryanoff, Edward S. Kimball, Wei He, Rosemary J. Santulli, Craig R. Schneider, Yong Gong, William A. Kinney, Craig J. Diamond, Tamara A. Miskowski
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6693-6702
A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of α4β1-VCAM-1 and α4β7-MAdCAM-1 interactions. Potency and α4β1/α4β7 selectivity were sensitive to the substituent
Autor:
Craig R. Schneider, Pamela J. Hornby, Michael R. D'Andrea, Edward S. Kimball, Nathaniel H. Wallace
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 1 (2010)
Frontiers in Pharmacology, Vol 1 (2010)
Cannabinoids are known to be clinically beneficial for control of appetite disorders and nausea/vomiting, with emerging data that they can impact other GI disorders, such as inflammation. Post-inflammatory irritable bowel syndrome (PI-IBS) is a condi
Autor:
S. P. Prouty, Pamela J. Hornby, N. H. Wallace, Edward S. Kimball, K. P. Pavlick, Craig R. Schneider
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 19(5)
Oil of mustard (OM), administered intracolonically, produces severe colitis in mice that is maximized within 3 days. The purpose of this study was to characterize the cytokine response, and to establish expression patterns of enteric neuronal mediato
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
Autor:
Yong Gong, Barbay Jk, Dennis J. Hlasta, Stephen M. Prouty, Scott A. Ballentine, Patricia Andrade-Gordon, Alexey B. Dyatkin, William Hageman, John A. Masucci, Rosemary J. Santulli, M. C. Fisher, Pamela J. Hornby, Wei He, N. H. Wallace, Bruce P. Damiano, Craig R. Schneider, Tamara A. Miskowski, Edward S. Kimball, Bruce E. Maryanoff
Publikováno v:
Journal of medicinal chemistry. 49(11)
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions. Concise syntheses were developed and applied fo