Výsledky vyhledávání - "Craig R. Salhoff"

CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography

Autor: Bryan G. Johnson, David O. Calligaro, Gerard J. Marek, Craig R. Salhoff, James A. Monn, Ce Zhang, Ann E. Kingston, Darryle D. Schoepp, Rebecca A. Wright

Publikováno v: Neuropharmacology. 66:89-98

Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73d836b0a3fb1f2cecc7f146afbcce84
https://doi.org/10.1016/j.neuropharm.2012.01.019

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Genetic deletion of CB1 receptors improves non-associative learning

Autor: Aldemar Degroot, Richard J. Davis, George G. Nomikos, Craig R. Salhoff

Publikováno v: Behavioural Brain Research. 162:161-164

Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f56a1753abeedcfdf7d4c0196e09a46
https://doi.org/10.1016/j.bbr.2005.02.018

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Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice

Autor: Susan Luecke, Craig R. Salhoff, Mark R. Wade, Donald R. Gehlert, Janice Shaw, Daniel G. Smith, George G. Nomikos, Richard J. Davis, Eleni T. Tzavara

Publikováno v: The Journal of Neuroscience. 25:914-922

Melanin-concentrating hormone (MCH) neurons and MCH-1 receptors (MCH1r) densely populate mesolimbic dopaminergic brain regions such as the nucleus accumbens (NAc). The regulation of dopamine by MCH1r was suggested to be an important mechanism underly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa2a1533bdd5e1abbf2dcbf061151e7
https://doi.org/10.1523/jneurosci.4079-04.2005

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The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions

Autor: Richard J. Davis, Xia Li, Craig R. Salhoff, George G. Nomikos, Eleni T. Tzavara, Kenneth W. Perry, Frank P. Bymaster, Jeffrey M. Witkin

Publikováno v: British Journal of Pharmacology. 138:544-553

1. In order to explore potential therapeutic implications of cannabinoid antagonists, the effects of the prototypical cannabinoid antagonist SR141716A on monoamine efflux from the medial prefrontal cortex and the nucleus accumbens of the rat were inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e4f1fd5cc801ed98df936592e72655
https://doi.org/10.1038/sj.bjp.0705100

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3,5-Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide-Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

Autor: John Goldsworthy, Darryle D. Schoepp, S. Richard Baker, Bryan G. Johnson, Craig R. Salhoff

Publikováno v: Journal of Neurochemistry. 63:769-772

Metabotropic glutamate receptors (mGluRs) are a heterogeneous family of G protein-coupled glutamate receptors that are linked to multiple second messenger systems in the CNS. In this study the selectivity of mGluR agonists for different mGluR second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa1212cbbf5ca591231fdd01e88c593
https://doi.org/10.1046/j.1471-4159.1994.63020769.x

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The Potent, Selective mGlu2/3 Receptor Agonist LY379268 Increases Extracellular Levels of Dopamine, 3,4-Dihydroxyphenylacetic Acid, Homovanillic Acid, and 5-Hydroxyindole-3-Acetic Acid in the Medial Prefrontal Cortex of the Freely Moving Rat

Autor: Kenneth W. Perry, Jayne Cartmell, Craig R. Salhoff, Darryle D. Schoepp, James A. Monn

Publikováno v: Journal of Neurochemistry. 75:1147-1154

Previous work has shown that the potent, selective metabotropic glutamate mGlu2/3 receptor agonist LY379268 acts like the atypical antipsychotic clozapine in behavioral assays. To investigate further the potential antipsychotic actions of this agent,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b3cfbb1a505fee7b890b42f553348
https://doi.org/10.1046/j.1471-4159.2000.0751147.x

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Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade

Autor: Craig R. Salhoff, Jayne Cartmell, Darryle D. Schoepp, Kenneth W. Perry, James A. Monn

Publikováno v: Neuropharmacology. 40:847-855

Our recent work (Cartmell et al., Journal of Neurochemistry, 75 (2000) 1147–1154) demonstrated that systemic injection of the potent, selective mGlu2/3 receptor agonist, LY379268, acutely increased extracellular levels of dopamine, its metabolites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1e6340a8daee7ac3956a39ea13f931
https://doi.org/10.1016/s0028-3908(01)00034-x

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LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

Autor: James A. Monn, David Bleakman, J. Paul Burnett, Nancy Gail Mayne, Darryle D. Schoepp, Craig R. Salhoff, Bryan G. Johnson, S.L. Cockerham, Su Wu, Ramamoorthy Belegaje, Rebecca A. Wright

Publikováno v: Neuropharmacology. 36:1-11

The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce26756481420e738a6760e53bee03d
https://doi.org/10.1016/s0028-3908(96)00160-8

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Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)

Autor: Joseph P. Tizzano, D D Schoepp, P. C. May, Craig R. Salhoff, A. I. Sacaan, K. S. Fuson, Paul L. Ornstein

Publikováno v: Journal of Neural Transmission. 103:905-916

Glutamate receptor-mediated excitotoxicity is linked to the activation of multiple receptors including those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-D-aspartate (NMDA), and kainate. In this study, the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bb8177c358301dbc5c11416098d1e6
https://doi.org/10.1007/bf01291781

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