Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Craig R. Malloy"'
Autor:
Eunsook S. Jin, Craig R. Malloy, Gaurav Sharma, Erin Finn, Kelly N.Z. Fuller, Yesenia Garcia Reyes, Mark A. Lovell, Sarkis C. Derderian, Jonathan A. Schoen, Thomas H. Inge, Melanie G. Cree
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102749- (2023)
Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are componen
Externí odkaz:
https://doaj.org/article/fa424f6953bc4591aa799946657b4ffa
Autor:
Min Hee Lee, Ian J. Neeland, Natalia de Albuquerque Rocha, Connor Hughes, Craig R. Malloy, Eunsook S. Jin
Publikováno v:
Metabolism Open, Vol 13, Iss , Pp 100161- (2022)
Background: Empagliflozin, a sodium glucose cotransporter 2 inhibitor, is a medication to treat type 2 diabetes. The effect of empagliflozin in persons without diabetes has received less attention. Here we conducted a randomized, double-blind placebo
Externí odkaz:
https://doaj.org/article/ab3866f8b4d44566904e3a2c5498cce7
Autor:
Stefan Stender, Vlad G. Zaha, Craig R. Malloy, Jessica Sudderth, Ralph J. DeBerardinis, Jae Mo Park
Publikováno v:
Hepatology Communications, Vol 4, Iss 3, Pp 425-433 (2020)
Carbon‐13 magnetic resonance spectroscopy (MRS) following oral intake of 13C‐labeled glucose is the gold standard for imaging glycogen metabolism in humans. However, the temporal resolution of previous studies has been >13 minutes. Here, we descr
Externí odkaz:
https://doaj.org/article/e975fa7feda54cc8ba025fb0cc728917
Autor:
John Kurhanewicz, Daniel B. Vigneron, Jan Henrik Ardenkjaer-Larsen, James A. Bankson, Kevin Brindle, Charles H. Cunningham, Ferdia A. Gallagher, Kayvan R. Keshari, Andreas Kjaer, Christoffer Laustsen, David A. Mankoff, Matthew E. Merritt, Sarah J. Nelson, John M. Pauly, Philips Lee, Sabrina Ronen, Damian J. Tyler, Sunder S. Rajan, Daniel M. Spielman, Lawrence Wald, Xiaoliang Zhang, Craig R. Malloy, Rahim Rizi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 1-16 (2019)
This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging’s (MRI’s) widespread clinical use, and provid
Externí odkaz:
https://doaj.org/article/84ebe3efefdc40839f297b3d92907a8a
Publikováno v:
Metabolism Open, Vol 9, Iss , Pp 100086- (2021)
Background: In our recent study using [U–13C3]glycerol, a small subset of hamsters showed an unusual profile of glycerol metabolism: negligible gluconeogenesis from glycerol plus conversion of glycerol to 1,3-propanediol (1,3PDO) and 3-hydroxypropi
Externí odkaz:
https://doaj.org/article/7e6ec6902fcc41fea9289e1b757430ca
Autor:
Edward P. Hackett, Marco C. Pinho, Crystal E. Harrison, Galen D. Reed, Jeff Liticker, Jaffar Raza, Ronald G. Hall, Craig R. Malloy, Surendra Barshikar, Christopher J. Madden, Jae Mo Park
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101885- (2020)
Summary: Traumatic brain injury (TBI) involves complex secondary injury processes following the primary injury. The secondary injury is often associated with rapid metabolic shifts and impaired brain function immediately after the initial tissue dama
Externí odkaz:
https://doaj.org/article/4510c21d949a44cb9914a6bfd1c3d925
Publikováno v:
Physiological Reports, Vol 8, Iss 16, Pp n/a-n/a (2020)
Abstract The liver regenerates NADPH via multiple pathways to maintain redox balance and reductive biosynthesis. The pentose phosphate pathway (PPP) contributes to hepatic lipogenesis by supplying NADPH, and it is thought to play a major role in resp
Externí odkaz:
https://doaj.org/article/9fa882835cd14ba89871de6f05a94314
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Externí odkaz:
https://doaj.org/article/9118e872584e43d796c87543bd99b66c
Autor:
Catherine A. Makarewich, Kedryn K. Baskin, Amir Z. Munir, Svetlana Bezprozvannaya, Gaurav Sharma, Chalermchai Khemtong, Akansha M. Shah, John R. McAnally, Craig R. Malloy, Luke I. Szweda, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3701-3709 (2018)
Summary: Micropeptide regulator of β-oxidation (MOXI) is a conserved muscle-enriched protein encoded by an RNA transcript misannotated as non-coding. MOXI localizes to the inner mitochondrial membrane where it associates with the mitochondrial trifu
Externí odkaz:
https://doaj.org/article/7104ce443c914948b23d40e5e3e40066
Autor:
John Kurhanewicz, Daniel B. Vigneron, Kevin Brindle, Eduard Y. Chekmenev, Arnaud Comment, Charles H. Cunningham, Ralph J. DeBerardinis, Gary G. Green, Martin O. Leach, Sunder S. Rajan, Rahim R. Rizi, Brian D. Ross, Warren S. Warren, Craig R. Malloy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 2, Pp 81-97 (2011)
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific
Externí odkaz:
https://doaj.org/article/f864942395bc46c69da70352adf9b6aa