Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Craig R Roy"'
Autor:
Sandhya Ganesan, Craig R Roy
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007955 (2019)
Most intracellular pathogens that reside in a vacuole prevent transit of their compartment to lysosomal organelles. Effector mechanisms induced by the pro-inflammatory cytokine Interferon-gamma (IFNγ) can promote the delivery of pathogen-occupied va
Externí odkaz:
https://doaj.org/article/45d583125ee745ebb2112a0af476e706
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006088 (2016)
Vacuolar bacterial pathogens are sheltered within unique membrane-bound organelles that expand over time to support bacterial replication. These compartments sequester bacterial molecules away from host cytosolic immunosurveillance pathways that indu
Externí odkaz:
https://doaj.org/article/e62f2d98c8964c4f8de2a9caf7df8d4a
Autor:
Caitlin E. Moss, Craig R. Roy
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Legionella pneumophila is an intracellular bacterial pathogen that replicates inside human alveolar macrophages to cause a severe pneumonia known as Legionnaires’ disease. L. pneumophila requires the Dot/Icm Type IV secretion system to del
Externí odkaz:
https://doaj.org/article/847fd50673e148679d991028695cc277
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159698 (2016)
Legionella pneumophila is a Gram-negative bacterium that can colonize both freshwater protozoa and human alveolar macrophages, the latter infection resulting in Legionnaires' disease. The intracellular lifecycle of L. pneumophila requires extensive m
Externí odkaz:
https://doaj.org/article/6c77e43168dd449cbafdd244457835f1
Autor:
Hayley J Newton, Lara J Kohler, Justin A McDonough, Morayma Temoche-Diaz, Emerson Crabill, Elizabeth L Hartland, Craig R Roy
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004286 (2014)
Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an array
Externí odkaz:
https://doaj.org/article/5c6f90b7549448818a425aabf83a2888
Autor:
Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David Lambright, Pietro De Camilli, Hiroki Nagai, Craig R Roy
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004222 (2014)
The Dot/Icm system of the intracellular pathogen Legionella pneumophila has the capacity to deliver over 270 effector proteins into host cells during infection. Important questions remain as to spatial and temporal mechanisms used to regulate such a
Externí odkaz:
https://doaj.org/article/264807b31ba5482dad5d8d46ec4484f5
Autor:
Marcia Folly-Klan, Eric Alix, Danièle Stalder, Pampa Ray, Lionel V Duarte, Anna Delprato, Mahel Zeghouf, Bruno Antonny, Valérie Campanacci, Craig R Roy, Jacqueline Cherfils
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003747 (2013)
The intracellular bacterial pathogen Legionella pneumophila (Lp) evades destruction in macrophages by camouflaging in a specialized organelle, the Legionella-containing vacuole (LCV), where it replicates. The LCV maturates by incorporating ER vesicle
Externí odkaz:
https://doaj.org/article/a560f605e7b34f1e9e3975483972bfaa
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54566 (2013)
The human pathogen Coxiella burnetii encodes a type IV secretion system called Dot/Icm that is essential for intracellular replication. The Dot/Icm system delivers bacterial effector proteins into the host cytosol during infection. The effector prote
Externí odkaz:
https://doaj.org/article/47f24c017f5844a9b3a1bc37bb739d72
Autor:
Eric Alix, Laurent Chesnel, Brad J Bowzard, Aimee M Tucker, Anna Delprato, Jacqueline Cherfils, David O Wood, Richard A Kahn, Craig R Roy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003012 (2012)
The Legionella pneumophila effector protein RalF functions as a guanine nucleotide exchange factor (GEF) that activates the host small GTPase protein ADP-ribosylation factor (Arf), and recruits this host protein to the vacuoles in which this pathogen
Externí odkaz:
https://doaj.org/article/759a597e3bb94a3b9c9514d4110f80a2
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002056 (2011)
Coxiella burnetii, the causative agent of human Q fever, is an intracellular pathogen that replicates in an acidified vacuole derived from the host lysosomal network. This pathogen encodes a Dot/Icm type IV secretion system that delivers bacterial pr
Externí odkaz:
https://doaj.org/article/d16fc1901aff4421a1d48be9f0e8e6bc