Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Craig R, Roy"'
Autor:
Caitlin E. Moss, Craig R. Roy
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Legionella pneumophila is an intracellular bacterial pathogen that replicates inside human alveolar macrophages to cause a severe pneumonia known as Legionnaires’ disease. L. pneumophila requires the Dot/Icm Type IV secretion system to del
Externí odkaz:
https://doaj.org/article/847fd50673e148679d991028695cc277
Autor:
Sandhya Ganesan, Natalie N. Alvarez, Samuel Steiner, Karen M. Fowler, Abigail K. Corona, Craig R. Roy
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of
Externí odkaz:
https://doaj.org/article/2ec18a5a684e409fa9dfe011d1d7c68f
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Type IV secretion systems (T4SSs) are sophisticated nanomachines used by many bacterial pathogens to translocate protein and DNA substrates across a host cell membrane. Although T4SSs have important roles in promoting bacterial infections, l
Externí odkaz:
https://doaj.org/article/7e1bcf1f2afc42b7b966cb330d2a0118
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic ins
Externí odkaz:
https://doaj.org/article/6c642b7b193d45158274212a71865767
Autor:
Sandhya Ganesan, Craig R Roy
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007955 (2019)
Most intracellular pathogens that reside in a vacuole prevent transit of their compartment to lysosomal organelles. Effector mechanisms induced by the pro-inflammatory cytokine Interferon-gamma (IFNγ) can promote the delivery of pathogen-occupied va
Externí odkaz:
https://doaj.org/article/45d583125ee745ebb2112a0af476e706
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate protective immune responses. In turn, host-adapted pathogens have evolved strategies to modulate these surveillance systems, which can promote dissemination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945fd8b4dfce9015a2d0abb634a4c569
https://doi.org/10.1073/pnas.2217602120
https://doi.org/10.1073/pnas.2217602120
Publikováno v:
Infect Immun
Coxiella burnetii is an obligate intracellular bacterial pathogen that has evolved a unique bi-phasic developmental cycle. The infectious form of C. burnetii is the dormant small cell variant (SCV) that transitions to a metabolically active large cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7460f2af01247274eb44df8d961f66
https://doi.org/10.1128/iai.00410-22
https://doi.org/10.1128/iai.00410-22
Autor:
Dolores L. Guzmán-Herrador, Samuel Steiner, Anabel Alperi, Coral González-Prieto, Craig R. Roy, Matxalen Llosa
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella
Externí odkaz:
https://doaj.org/article/1babe0514dc44c08b642e2a3b36ce1c3
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006088 (2016)
Vacuolar bacterial pathogens are sheltered within unique membrane-bound organelles that expand over time to support bacterial replication. These compartments sequester bacterial molecules away from host cytosolic immunosurveillance pathways that indu
Externí odkaz:
https://doaj.org/article/e62f2d98c8964c4f8de2a9caf7df8d4a
Autor:
Lara J. Kohler, Shawna C. O. Reed, Shireen A. Sarraf, David D. Arteaga, Hayley J. Newton, Craig R. Roy
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
Externí odkaz:
https://doaj.org/article/4de5bb7ff5534e40982cf99a07df7c3c