Výsledky vyhledávání - "Craig P. Montgomery"

Supplementary Figure 4 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

Autor: Adrian L. Harris, Richard Poulsom, Craig P. Montgomery, Angela J. Russell, Partha S. Chowdhury, Herren Wu, Emma T. Bowden, Cameron Snell, Wen Shi, Esther Bridges, Helen Sheldon, Russell Leek, Helen Turley, Chern Ein Oon, Richard C.A. Sainson, Ji-Liang Li

PDF file - 1.84 MB, Pericyte coverage on tumor microvessels did not associate with the tumor resistance to bevacizumab (bev). Fresh frozen tumor samples were taken from Figure 2D and double stained for CD31 (green) and the pericytic marker NG2 (red).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0d956ee57b02a5fab0aa923b49381d
https://doi.org/10.1158/0008-5472.22388571.v1

Zobrazit plný text záznamu

Supplementary Figure 5 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 4.04 MB, DLL4 downregulated the expression of VEGFR3 in human microvascular EC in vitro and in xenograft tumor in vivo. (A). The expression of VEGFR3 at a mRNA level was decreased in human micrcovascular EC (hMEC-1) cultured in vitro after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d6682e3b89fae90af9419c56c02c8
https://doi.org/10.1158/0008-5472.22388568.v1

Zobrazit plný text záznamu

Supplementary Figure 1 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 473K, Blockade of Notch signaling in endothelial cells by DBZ in vitro. Western blotting showed that the protein levels of activated Notch intracellular domain (NICD) and Hes-1 were significantly reduced by DBZ in human umbilical vein endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1533a7921f0c60356f736c1c9a6af6
https://doi.org/10.1158/0008-5472.22388580.v1

Zobrazit plný text záznamu

Supplementary Figure 6 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF file - 740K, Neither anti-EphrinB2 nor sEphB4 affected the growth of U87-EV tumors in vivo. Compared to the control, neutralizing anti-EphrinB2 antibody (B2) alone (blue arrowhead) did not affect the tumor growth. Also, combined anti-EphrinB2 ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3bbe38c8de0da3d76fe6a344de7054
https://doi.org/10.1158/0008-5472.22388565

Zobrazit plný text záznamu

Supplementary Figure 2 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF 712K, In vivo expression of mHey1, a downstream target of Notch signaling in the mouse stroma/ECs of U87 tumors. The relative expression of mHey1 in tumor tissues was analyzed by qPCR against mRNA extracted from xenograft tumors using mouse speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4648d9cad903096a9fe67f46f350355a
https://doi.org/10.1158/0008-5472.22388577

Zobrazit plný text záznamu

Supplementary Figure 3 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

PDF 584K, Combination therapy by blockade of both Notch signaling and the VEGF pathway displayed a synergistic therapeutic efficacy in HT1080 xenografted tumors. Single therapy with either DBZ or bevacizumab did not affect tumor growth and animal sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c54692481d24888a75550c2919dfee4
https://doi.org/10.1158/0008-5472.22388574

Zobrazit plný text záznamu

Emissive and Cell-Permeable 3-Pyridyl- and 3-Pyrazolyl-4-azaxanthone Lanthanide Complexes and Their Behaviourin cellulo

Autor: Andrei S. Batsanov, Craig P. Montgomery, Laurent Lamarque, Elizabeth J. New, Lars O. Palsson, David Parker

Publikováno v: ResearcherID

A series of seven emissive europium(III) and terbium(III) complexes was prepared, incorporating a 3-pyridyl-4-azaxanthone or 3-pyrazolyl-4-azaxanthone sensitising moiety within a polydentate macrocyclic ligand. High overall emission quantum yields in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794e9d1d6bdad666c0413220dca5779a
https://doi.org/10.1002/hlca.200900122

Zobrazit plný text záznamu

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo

Autor: Wen Shi, Angela J. Russell, Partha S. Chowdhury, Craig P. Montgomery, Emma T. Bowden, Helen Sheldon, Esther Bridges, Herren Wu, Richard Poulsom, Ji-Liang Li, Richard C.A. Sainson, Chern Ein Oon, Adrian L. Harris, Cameron Snell, Russell Leek, Helen Turley

Publikováno v: Cancer research. 71(18)

Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced human glioblastoma cells wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ffd565ca80bb1596f34b5414e690f
http://ora.ox.ac.uk/objects/uuid:3e866ae3-d35e-40bd-bed2-f056244e0dcd

Zobrazit plný text záznamu

ChemInform Abstract: Cell-Penetrating Metal Complex Optical Probes: Targeted and Responsive Systems Based on Lanthanide Luminescence

Autor: Elizabeth J. New, Benjamin S. Murray, Robert Pal, David Parker, Craig P. Montgomery

Publikováno v: ChemInform. 40

To understand better the structure and function of biological systems, cell biologists and biochemists would like to have methods that minimally perturb living systems. The development of emissive optical probes is essential for improving our observa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::208fa94cd03385616ab068b1898e54ac
https://doi.org/10.1002/chin.200947277

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání