Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Craig Mickanin"'
Autor:
Jonathan Yen, Michael Fiorino, Yi Liu, Steve Paula, Scott Clarkson, Lisa Quinn, William R. Tschantz, Heath Klock, Ning Guo, Carsten Russ, Vionnie W. C. Yu, Craig Mickanin, Susan C. Stevenson, Cameron Lee, Yi Yang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential cure for monogenic blood diso
Externí odkaz:
https://doaj.org/article/7126e75f7f804ba7a87cf87864786123
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Autor:
Sandipan Chatterjee, Joseph D Szustakowski, Nirmala R Nanguneri, Craig Mickanin, Mark A Labow, Axel Nohturfft, Kumlesh K Dev, Rajeev Sivasankaran
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5197 (2009)
BackgroundLipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and synthesis of cholesterol, fatty aci
Externí odkaz:
https://doaj.org/article/f9c070563cbb4b3cb0db1a17be7bb0ba
Autor:
Yi Liu, Vionnie W. Yu, Qi Zhang, Madhura Panditrao, Yi Yang, Alberto Del Rio-Espinola, Daher Ibrahim Aibo, Azeddine Elhajouji, Konrad Mueller, Karin Abitorabi, Daniel O'Connell, Bo Han, Nishit Patel, Carsten Russ, Craig Mickanin, Timothy K. MacLachlan, Susan C. Stevenson
Publikováno v:
Blood. 140:12982-12983
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55379b4ef8691e01ecc5df23f09d127e
https://doi.org/10.1182/blood-2022-159892
https://doi.org/10.1182/blood-2022-159892
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e55c3fe4c3ecfba28cea037cdc9ce
https://doi.org/10.1126/science.aad5944
https://doi.org/10.1126/science.aad5944
Autor:
Xiaomo Jiang, Andreas Bauer, Craig Mickanin, Olga Charlat, Wenqing Xu, Lei Ji, Bo Jiang, Amy Chen, Feng Cong, Xiaoxue Yan
Publikováno v:
Genesdevelopment. 31(9)
The Wnt/β-catenin signaling pathway plays essential roles in embryonic development and adult tissue homeostasis. Axin is a concentration-limiting factor responsible for the formation of the β-catenin destruction complex. Wnt signaling itself promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd6ed2abb6bc1c9a64c2de67deaddcb
https://pubmed.ncbi.nlm.nih.gov/28546513
https://pubmed.ncbi.nlm.nih.gov/28546513
Autor:
Craig Mickanin, Linda Bagdasarian, Gregory R. Hoffman, Jeffery A. Porter, Kay Xiang, Huili Zhai, Zainab Jagani, Matthew J. Meyer, Frank Buxton, Vic E. Myer, Nadire Ramadan, Rami Rahal, Elizabeth Frias, Charles W. M. Roberts, Janina Huber, Frank Stegmeier, Kristy Haas, Gregory McAllister, Tanushree Phadke, Mariela Jaskelioff, Rodrigo Romero, Veronica Saenz-Vash, Alicia Lindeman, Dongshu Chen, Boris G. Wilson, Margaret E. McLaughlin, Nicholas Keen
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3128-3133
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7b9048773c54b470f77944d734533b
https://doi.org/10.1073/pnas.1316793111
https://doi.org/10.1073/pnas.1316793111
Autor:
Fangfang Zhou, Craig Mickanin, Chris Lu, Li Hui, Amaya García de Vinuesa, Peter J. K. Kuppen, Kelly-Ann Sheppard, Esther M. de Kruijf, Yihao Li, Peter ten Dijke, Adrien Rousseau, Wilma E. Mesker, Yvette Drabsch, Long Zhang, Andreas Bauer
Publikováno v:
Molecular Cell, 51(5), 559-572
TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component mediating pro-oncogenic TGF-β-induced SMAD and non-SMAD signaling. Upon TGF-β stimulation, TRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9639a506eb4544765bc79c525e0471
Autor:
Zuncai Wang, Walter Carbone, Jennifer Kelliher, Rowena DeJesus, Guglielmo Roma, John S. Reece-Hoyes, Aylwin Ng, Francesca Moretti, Craig Mickanin, Phil Bergman, Alicia Lindeman, Shanming Liu, Gregory R. Hoffman, John Alford, Martin Beibel, Beat Nyfeler, Leon Murphy, Carsten Russ, John A. Tallarico, Gregory McAllister, Judith Knehr, Ramnik J. Xavier, Elizabeth Frias, Jeffery A. Porter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969d0bf3b951cb089bc956ceb830f70e
https://doi.org/10.7554/elife.17290.014
https://doi.org/10.7554/elife.17290.014
Autor:
Craig Mickanin, Gregory R. Hoffman, Jeffery A. Porter, Guglielmo Roma, Carsten Russ, Gregory McAllister, Walter Carbone, John A. Tallarico, Beat Nyfeler, Zuncai Wang, Jennifer Kelliher, Francesca Moretti, Ramnik J. Xavier, Leon Murphy, John S. Reece-Hoyes, John Alford, Phil Bergman, Alicia Lindeman, Elizabeth Frias, Shanming Liu, Rowena DeJesus, Judith Knehr, Martin Beibel, Aylwin Ng
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4076c6c00fbbd9562afd9c0e08da058
https://pubmed.ncbi.nlm.nih.gov/27351204
https://pubmed.ncbi.nlm.nih.gov/27351204