Overexpression of PPARγ specifically in pancreatic β-cells exacerbates obesity-induced glucose intolerance, reduces β-cell mass, and alters islet lipid metabolism in male mice.

Autor: Hogh KL; Northern Medical Program (K.N.H., M.N.C., C.E.U., J.D.F., A.P.R., S.L.G.), University of Northern British Columbia, Prince George, British Columbia, Canada V2N 4Z9; Department of Cellular and Physiological Sciences and Faculty of Medicine (A.A., R.K.B.), University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4; VTT Technical Research Centre of Finland (H.N., M.O.), Espoo FI-02044, Finland; Steno Diabetes Center A/S (H.N., M.O.), Gentofte, Denmark; and Child and Family Research Institute (M.S.), Vancouver, British Columbia, Canada V6T 1Z1., Craig MN, Uy CE, Nygren H, Asadi A, Speck M, Fraser JD, Rudecki AP, Baker RK, Orešič M, Gray SL

Publikováno v: Endocrinology [Endocrinology] 2014 Oct; Vol. 155 (10), pp. 3843-52. Date of Electronic Publication: 2014 Jul 22.