Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Craig M. Keenan"'
Autor:
Craig M. Keenan, Lorenzo Ramos-Mucci, Ioannis Kanakis, Peter I. Milner, Andrew Leask, David Abraham, George Bou-Gharios, Blandine Poulet
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
CCN2 is a matricellular protein involved in several crucial biological processes. In particular, CCN2 is involved in cartilage development and in osteoarthritis. Ccn2 null mice exhibit a range of skeletal dysmorphisms, highlighting its importance in
Externí odkaz:
https://doaj.org/article/cf3a3ff5ec074a19ac7c76eb85a76bb0
Autor:
Ke Liu, Lorenzo Ramos Mucci, George Bou-Gharios, Ioannis Kanakis, Mohammad Alhashmi, Blandine Poulet, Craig M. Keenan
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611180
Cartilage is a specialized skeletal tissue with a unique extracellular matrix elaborated by its resident cells, chondrocytes. The tissue presents in several forms, including growth plate and articular cartilage, wherein chondrocytes follow a differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::955839f9aff1ccfd42111c04740e52c0
https://doi.org/10.1007/978-1-0716-1119-7_3
https://doi.org/10.1007/978-1-0716-1119-7_3
Autor:
Peter Wilson, James A. Gallagher, Henry R. Edwards, George Bou-Gharios, Hazel Sutherland, Craig M. Keenan, Lakshminarayan R. Ranganath, Juliette H. Hughes, Jonathan C. Jarvis
Publikováno v:
Calcified Tissue International
Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38cfc6f01d578ca88fbb5c0fbf6fb61
http://livrepository.liverpool.ac.uk/3104257/1/Hughes_et_al-2020-Calcified_Tissue_International.pdf
http://livrepository.liverpool.ac.uk/3104257/1/Hughes_et_al-2020-Calcified_Tissue_International.pdf
Autor:
Ioannis Kanakis, Andrew Leask, Craig M. Keenan, Blandine Poulet, Lorenzo Ramos-Mucci, Peter Milner, George Bou-Gharios, David Abraham
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
CCN2 is a matricellular protein involved in several critical biological processes. In particular, CCN2 is involved in cartilage development and in osteoarthritis. CCN2 null mice exhibit a range of skeletal dysmorphisms, highlighting its importance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2b377fe4353485612a4513395e7afb
http://dmm.biologists.org/content/13/7/dmm044719
http://dmm.biologists.org/content/13/7/dmm044719
Autor:
Peter Wilson, Andrew T. Hughes, Brendan P. Norman, Antonius Plagge, Hazel Sutherland, James A. Gallagher, Lakshminarayan R. Ranganath, George Bou-Gharios, Ke Liu, Juliette H. Hughes, Anna M. Milan, Takao Sakai, Craig M. Keenan
Publikováno v:
Human molecular genetics
Human Molecular Genetics
Human Molecular Genetics
Alkaptonuria is an inherited disease caused by homogentisate 1,2-dioxygenase (HGD) deficiency. Circulating homogentisic acid (HGA) is elevated and deposits in connective tissues as ochronotic pigment. In this study, we aimed to define developmental a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d6274dabaa35aa490b451cac9556e0
Autor:
Craig M. Keenan, Hazel Sutherland, Lakshminarayan R. Ranganath, Ian A. Prior, James A. Gallagher, Jonathan C. Jarvis, Alison J. Beckett
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
SCIENTIFIC REPORTS
Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports
The structure, ultrastructure and function of hyaline articular cartilage (HAC) and subchondral bone (SCB), and their involvement in the pathogenesis of osteoarthritis (OA) have been extensively researched. However, much less attention has been focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc57e5e9cb5eb55223e7587d0f23716d
https://doi.org/10.1038/s41598-019-47545-2
https://doi.org/10.1038/s41598-019-47545-2
Autor:
Ioannis Kanakis, L. Ramos, George Bou-Gharios, David Abraham, Peter Milner, Blandine Poulet, Craig M. Keenan
Publikováno v:
Osteoarthritis and Cartilage. 27:S162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886121e2c06ff5cb3f769dacdc0a1535
https://doi.org/10.1016/j.joca.2019.02.240
https://doi.org/10.1016/j.joca.2019.02.240
Publikováno v:
Osteoarthritis and Cartilage. 26:S76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c08b0a31c5c742f62f4aedcd705e052
https://doi.org/10.1016/j.joca.2018.02.161
https://doi.org/10.1016/j.joca.2018.02.161
Autor:
Peter Milner, Craig M. Keenan, Blandine Poulet, R.J. Van 'T Hof, David Abraham, George Bou-Gharios, Ioannis Kanakis, Andrew Leask, A. Carter
Publikováno v:
ResearcherID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2401b1f5df8580be8ce130a88fe374
https://doi.org/10.1016/j.joca.2018.02.168
https://doi.org/10.1016/j.joca.2018.02.168
Autor:
Craig M. Keenan, Hazel Sutherland, Peter Wilson, Lakshminarayan R. Ranganath, James A. Gallagher, Jonathan C. Jarvis, Eftychia E. Psarelli, Trevor Cox, Andrew Preston
Publikováno v:
JIMD Reports ISBN: 9783662482261
Alkaptonuria (AKU) is an ultrarare autosomal recessive disorder resulting from a deficiency of homogentisate 1,2 dioxygenase (HGD), an enzyme involved in the catabolism of phenylalanine and tyrosine. Loss of HGD function prevents metabolism of homoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36332fd88f5ab3551c1b59dcbe84dea
https://doi.org/10.1007/8904_2015_437
https://doi.org/10.1007/8904_2015_437