Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Craig M. Coopersmith"'
Autor:
Jerome C. Anyalebechi, Yini Sun, Carolyn Davis, Maylene E. Wagener, Zhe Liang, Eileen M. Burd, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionA hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that treatment with
Externí odkaz:
https://doaj.org/article/429754ade8b144558594280f7c10d7ec
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis while also driving inflammatory signaling. Targeting cell death mediators w
Externí odkaz:
https://doaj.org/article/49a246879e3c4921ac49ca14bd7baa28
Autor:
Rui Moreno, Andrew Rhodes, Lise Piquilloud, Glenn Hernandez, Jukka Takala, Hayley B. Gershengorn, Miguel Tavares, Craig M. Coopersmith, Sheila N. Myatra, Mervyn Singer, Ederlon Rezende, Hallie C. Prescott, Márcio Soares, Jean-François Timsit, Dylan W. de Lange, Christian Jung, Jan J. De Waele, Greg S. Martin, Charlotte Summers, Elie Azoulay, Tomoko Fujii, Anthony S. McLean, Jean-Louis Vincent
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-5 (2023)
Abstract The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the last few dec
Externí odkaz:
https://doaj.org/article/9dcf960bf25e4ea7bc09ac3f073c577e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterize
Externí odkaz:
https://doaj.org/article/373c77ea86584b28ad0dc557309905b3
Autor:
Mehak Arora, Carolyn M. Davis, Niraj R. Gowda, Dennis G. Foster, Angana Mondal, Craig M. Coopersmith, Rishikesan Kamaleswaran
Publikováno v:
Bioengineering, Vol 10, Iss 8, p 946 (2023)
Acute Respiratory Distress Syndrome (ARDS) is a severe lung injury with high mortality, primarily characterized by bilateral pulmonary opacities on chest radiographs and hypoxemia. In this work, we trained a convolutional neural network (CNN) model t
Externí odkaz:
https://doaj.org/article/3e30f581f0e740fa9ec1af1bee610d9e
Autor:
Seibi Kobara, PT, MPH, Milad G. Rad, MS, Jocelyn R. Grunwell, PhD, Craig M. Coopersmith, MD, Rishikesan Kamaleswaran, PhD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 12, p e0818 (2022)
OBJECTIVES:. To investigate the relationship between ICU-acquired weakness (ICUAW) signatures and sepsis-related mortality using gene expression from the blood within 24 hours of sepsis onset. DESIGN:. Observational study using differential gene expr
Externí odkaz:
https://doaj.org/article/ab0be90444a148118be938804681eae9
Autor:
Ankita Agarwal, MD, MSc, Jen-Ting Chen, MD, MS, Craig M. Coopersmith, MD, MCCM, Joshua L. Denson, MD, MS, Neal W. Dickert, MD, PhD, Lauren E. Ferrante, MD, MHS, Hayley B. Gershengorn, MD, Adhiraj D. Gosine, MD, Bradley J. Hayward, MD, Navneet Kaur, MD, Akram Khan, MD, Courtney Lamberton, MD, Douglas Landsittel, PhD, Patrick G. Lyons, MD, MSc, Mark E. Mikkelsen, MD, MSCE, Nandita R. Nadig, MD, MSCR, Anthony P. Pietropaoli, MD, MPH, Brian R. Poole, MD, Elizabeth M. Viglianti, MD, MPH, MSc, Jonathan E. Sevransky, MD, MHS, on behalf of SCCM Discovery Network
Publikováno v:
Critical Care Explorations, Vol 4, Iss 10, p e0774 (2022)
OBJECTIVES:. The optimal staffing model for physicians in the ICU is unknown. Patient-to-intensivist ratios may offer a simple measure of workload and be associated with patient mortality and physician burnout. To evaluate the association of physicia
Externí odkaz:
https://doaj.org/article/52b157d170d744e2ab2fe494a6a099b4
Autor:
Nathan J. Klingensmith, Katherine T. Fay, David A. Swift, Julia M.R. Bazzano, John D. Lyons, Ching-wen Chen, Mei Meng, Kimberly M. Ramonell, Zhe Liang, Eileen M. Burd, Charles A. Parkos, Mandy L. Ford, Craig M. Coopersmith
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Expression of the tight junction–associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A –/– mice have increased gut permeability, yet parad
Externí odkaz:
https://doaj.org/article/fbfc530dda6d4b10a3967d7271e7af69
Autor:
Mark E. Nunnally, Ricard Ferrer, Greg S. Martin, Ignacio Martin-Loeches, Flavia R. Machado, Daniel De Backer, Craig M. Coopersmith, Clifford S. Deutschman, For the Surviving Sepsis Campaign Reasearch Committee
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-26 (2021)
Abstract Objective To identify priorities for administrative, epidemiologic and diagnostic research in sepsis. Design As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee,
Externí odkaz:
https://doaj.org/article/958bc210860441aa991513e4a8a25fda
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Autor:
Subhashis Pal, Daniel S. Perrien, Tetsuya Yumoto, Roberta Faccio, Andreea Stoica, Jonathan Adams, Craig M. Coopersmith, Rheinallt M. Jones, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the role of the microbiome in tumor gro
Externí odkaz:
https://doaj.org/article/0ac1f9b7c55d481081666201ef90533a