Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Craig M Coopersmith"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301281 (2024)
Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reper
Externí odkaz:
https://doaj.org/article/f3612217c9474d93a31eb747194507e9
Autor:
Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0246270 (2021)
During infectious disease, pathogen load drives inflammation and immune response that together contribute to tissue injury often resulting in organ dysfunction. Pulmonary failure in SARS-CoV2-infected hospitalized COVID-19 patients is one such promin
Externí odkaz:
https://doaj.org/article/a29f93cb0fe84b6992d31c454a7c8bf4
Autor:
Benyam P Yoseph, Elise Breed, Christian E Overgaard, Christina J Ward, Zhe Liang, Maylene E Wagener, Daniel R Lexcen, Elizabeth R Lusczek, Greg J Beilman, Eileen M Burd, Alton B Farris, David M Guidot, Michael Koval, Mandy L Ford, Craig M Coopersmith
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239568 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0062792.].
Externí odkaz:
https://doaj.org/article/26818326965f4f418f4dc66d627bc330
Autor:
Jianfeng Xie, Jennifer M Robertson, Ching-Wen Chen, Wenxiao Zhang, Craig M Coopersmith, Mandy L Ford
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191065 (2018)
The presence of pre-existing malignancy in murine hosts results in increased immune dysregulation and risk of mortality following a septic insult. Based on the known systemic immunologic changes that occur in cancer hosts, we hypothesized that the pr
Externí odkaz:
https://doaj.org/article/b3724927eeda486c8ef9526b6d5f6e67
Autor:
Katherine T Fay, Deena B Chihade, Ching-Wen Chen, Nathan J Klingensmith, John D Lyons, Kimberly Ramonell, Zhe Liang, Craig M Coopersmith, Mandy L Ford
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202656 (2018)
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3+ Treg, and T cell apoptosis. However, the role of CD43 dur
Externí odkaz:
https://doaj.org/article/63720976cc9241e6a1b41a74ef1704f7
Autor:
Kimberly M Ramonell, Wenxiao Zhang, Annette Hadley, Ching-Wen Chen, Katherine T Fay, John D Lyons, Nathan J Klingensmith, Kevin W McConnell, Craig M Coopersmith, Mandy L Ford
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188882 (2017)
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4
Externí odkaz:
https://doaj.org/article/d3b27f32140041188bab76e831d6711c
Autor:
Lindsay M Margoles, Rohit Mittal, Nathan J Klingensmith, John D Lyons, Zhe Liang, Mara A Serbanescu, Maylene E Wagener, Craig M Coopersmith, Mandy L Ford
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165886 (2016)
Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use ar
Externí odkaz:
https://doaj.org/article/3f8497ba4fac4da69a7b9a329945087b
Autor:
John D Lyons, Rohit Mittal, Katherine T Fay, Ching-Wen Chen, Zhe Liang, Lindsay M Margoles, Eileen M Burd, Alton B Farris, Mandy L Ford, Craig M Coopersmith
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149069 (2016)
BACKGROUND:Mortality is significantly higher in septic patients with cancer than in septic patients without a history of cancer. We have previously described a model of pancreatic cancer followed by sepsis from Pseudomonas aeruginosa pneumonia in whi
Externí odkaz:
https://doaj.org/article/36301c62943248e0b1c0117ea1c69702
Publikováno v:
Western Journal of Emergency Medicine, Vol 12, Iss 4, Pp 489-495 (2011)
Introduction: The objective of this study was to evaluate emergency medicine physician and nurse acceptance of nonnurse, nonphysician screening for geriatric syndromes. Methods: This was a single-center emergency department (ED) survey of physicians
Externí odkaz:
https://doaj.org/article/e2f6e5f72a324a45995deab1728fe3d1
Autor:
Rohit Mittal, Maylene Wagener, Elise R Breed, Zhe Liang, Benyam P Yoseph, Eileen M Burd, Alton B Farris, Craig M Coopersmith, Mandy L Ford
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e93523 (2014)
While much of cancer immunology research has focused on anti-tumor immunity both systemically and within the tumor microenvironment, little is known about the impact of pre-existing malignancy on pathogen-specific immune responses. Here, we sought to
Externí odkaz:
https://doaj.org/article/31e83b4735fe437e86aaef097708f8e5