TASP1 mutation in a female with craniofacial anomalies, anterior segment dysgenesis, congenital immunodeficiency and macrocytic anemia

Autor: Daniel M. Balkin, Menitha Poranki, Craig M. Forester, Morna J. Dorsey, Anne Slavotinek, Jason H. Pomerantz

Publikováno v: Molecular Genetics & Genomic Medicine, Vol 7, Iss 9, Pp n/a-n/a (2019)

Abstract Background Threonine Aspartase 1 (Taspase 1) is a highly conserved site‐specific protease whose substrates are broad‐acting nuclear transcription factors that govern diverse biological programs, such as organogenesis, oncogenesis, and tu

Externí odkaz: https://doaj.org/article/daac9c20b12444b2b230f0a725fff6ac

Aging through an epitranscriptomic lens

Autor: Rochelle Buffenstein, Mary McMahon, Craig M. Forester

Publikováno v: Nature Aging. 1:335-346

The mechanistic causes of aging, the time-related decline in function and good health that leads to increased mortality, remain poorly understood. Here we propose that age-dependent alteration of the epitranscriptome, encompassing more than 150 chemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6dc9fcfbd5b2f852db3f54e381cb84e
https://doi.org/10.1038/s43587-021-00058-y

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Autor: Hannah D. Rosenblatt, Laura D. Attardi, Leila Shokat, Maria Barna, Craig H. Kerr, Margot E. Bowen, Pallavi S. Krishnarao, Davide Ruggero, Gerald C. Tiu, Olena Zhulyn, Nitin Raj, Craig M. Forester

SUMMARYIn ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes, such as limb and craniofacial defects as well as bone marrow failure. What accounts for such tissue-selective manifestations as a result of mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d9905ebf4848557de806b64cbf215f8
https://doi.org/10.1101/2020.06.24.167940

TASP1 mutation in a female with craniofacial anomalies, anterior segment dysgenesis, congenital immunodeficiency and macrocytic anemia

Autor: Menitha Poranki, Craig M. Forester, Morna J. Dorsey, Jason H. Pomerantz, Anne Slavotinek, Daniel M. Balkin

Publikováno v: Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, vol 7, iss 9
Molecular Genetics & Genomic Medicine, Vol 7, Iss 9, Pp n/a-n/a (2019)

Background Threonine Aspartase 1 (Taspase 1) is a highly conserved site‐specific protease whose substrates are broad‐acting nuclear transcription factors that govern diverse biological programs, such as organogenesis, oncogenesis, and tumor progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07071468f4d2ab8ffdc292d66bdfdaeb
http://europepmc.org/articles/PMC6732342

Revealing nascent proteomics in signaling pathways and cell differentiation

Autor: Craig M. Forester, Alma L. Burlingame, Davide Ruggero, Juan A. Oses-Prieto, Nancy J. Phillips, Robert J. Chalkley, Anatoly Urisman, Li Zhang, Q Zhao

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 10
Proceedings of the National Academy of Sciences of the United States of America

Significance Deciphering which networks of genes allow cells to rapidly respond to environmental cues is key to understanding processes such as proliferation, differentiation, and death. Here, we describe a technique to quantitatively identify nascen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84f35bc0d031097dfe5ba8590d3747a
https://escholarship.org/uc/item/8mx7k51m