Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Craig Leighton"'
Autor:
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S. Nirujogi, Anna I. Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R. Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A. Rusakov, Dario R. Alessi, Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an SNCA mutation d
Externí odkaz:
https://doaj.org/article/fc1ba7fa6d614cbe962ce2b5a05c4fa6
Autor:
Alexandre Chappard, Craig Leighton, Rebecca S. Saleeb, Kiani Jeacock, Sarah R. Ball, Katie Morris, Owen Kantelberg, Ji‐Eun Lee, Elsa Zacco, Annalisa Pastore, Margaret Sunde, David J. Clarke, Patrick Downey, Tilo Kunath, Mathew H. Horrocks
Publikováno v:
Chappard, A, Leighton, C, Saleeb, R S, Jeacock, K, Ball, S, Morris, K, Kantelberg, O, Lee, J E, Zacco, E, Pastore, A, Sunde, M, Clarke, D J, Downey, P, Kunath, T & Horrocks, M H 2023, ' Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates ', Angewandte Chemie-International Edition, vol. 62, no. 15, e202216771 . https://doi.org/10.1002/anie.202216771
Protein misfolding and aggregation into oligomeric and fibrillar structures is a common feature of many neurogenerative disorders. Single-molecule techniques have enabled characterization of these lowly abundant, highly heterogeneous protein aggregat
Publikováno v:
Biophysical Journal. 118:149a