Zobrazeno 1 - 10 of 71 pro vyhledávání: '"Craig L. Francis"'
1
Akademický článek
New heteroatom-rich ring systems from N,N-dialkyl-N’-chlorosulfonyl chloroformamidines
Autor: Craig L. Francis
Publikováno v: ARKIVOC, Vol 2016, Iss 1, Pp 212-275 (2016)
Externí odkaz: https://doaj.org/article/77c78e9be4e9419d93e93b25b3875587
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2
Akademický článek
5-Amino-3-(diethylamino)-5H-benzo[4,5]imidazo[1,2-b][1,2,4,6]thiatriazine 1,1-Dioxide
Autor: Victor Tran, Craig M. Forsyth, Craig L. Francis
Publikováno v: Molbank, Vol 2018, Iss 3, p M1018 (2018)
In the quest for discovery of novel bioactive molecules, new heterocyclic ring systems provide templates for exploration of uncharted chemical space. Herein, we describe the synthesis of a new benzo[4,5]imidazo[1,2-b][1,2,4,6]thiatriazine derivative
Externí odkaz: https://doaj.org/article/a8cf0bea5b694192a44350842056afcb
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6
1-Benzyloxy-5-phenyltetrazole derivatives highly active against androgen receptor-dependent prostate cancer cells
Autor: Shiting Zhao, Abdelsalam S. Ali, Xinyu Kong, Yan Zhang, Xiaomin Liu, Melissa A. Skidmore, Craig M. Forsyth, G. Paul Savage, Donghai Wu, Yong Xu, Craig L. Francis
Publikováno v: European journal of medicinal chemistry. 246
A series of 1-benzyloxy-5-phenyltetrazole derivatives and similar compounds were synthesized and evaluated for their in vitro inhibitory activity against androgen-receptor-dependent (22Rv1) and androgen-receptor independent (PC3) prostate cancer cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37d60220010735cbbaeb72a476809cc
https://pubmed.ncbi.nlm.nih.gov/36495632
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7
Crystal structures of two 2,3-di­ethyl­naphtho­[2,3-g]quinoxaline-6,11-dione derivatives
Autor: Craig M. Forsyth, Craig L. Francis
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
The syntheses and crystal structures of two 2,3-di­ethyl­naphtho­quinoxaline-6-11-dione derivatives are described. Mol­ecules of C20H16N2O4 (II) are near planar and form stacks down the c axis through π–π ring inter­actions. In the substitut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366dd07275c8f23c27a7cb8edc6d24c9
http://europepmc.org/articles/PMC5598832
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8
Protecting keratin fiber with water soluble N-substituted maleimides in high temperature processes
Autor: Jill McDonnell, John Chiefari, John Tsanaktsidis, Jeffrey S. Church, Jackie Y. Cai, Craig L. Francis
Publikováno v: Fibers and Polymers. 15:2247-2252
This paper reports a facile method for protecting keratin fiber with water soluble N-substituted maleimides during high temperature processing in aqueous solutions. Three water soluble N-substituted maleimides, including aliphatic and aromatic maleim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e49b4c405cd1e27af2dcc38ec4b66ad
https://doi.org/10.1007/s12221-014-2247-8
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9
2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus
Autor: Kevin N. Winzenberg, Teresa Cablewski, Abdelselam Ali, Roger M. Sargent, David G. Sawutz, Ashit K. Ganguly, Craig L. Francis
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:4160-4163
A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD99 values of 30 nM, which is comparable to that of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060cbaef95d2a075fc9f23dbd8c37f1d
https://doi.org/10.1016/j.bmcl.2011.05.096
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10
Structural Basis for a New Mechanism of Inhibition of H I V-1 Integrase Identified by Fragment Screening and Structure-Based Design
Autor: John Deadman, G. Paul Savage, Craig L. Francis, John H. Ryan, Thomas S. Peat, Jessica A. Smith, Dharshini Jeevarajah, Jonathan Coates, Janet Newman, Lisa Jane Winfield, Del Lucent, Giang Thanh Le, Neeranat Thienthong, Eric Dale Jones, David Ian Rhodes, Nick Vandegraaff
Publikováno v: Antiviral Chemistry and Chemotherapy. 21:155-168
Background: HIV-1 integrase is a clinically validated therapeutic target for the treatment of HIV-1 infection, with one approved therapeutic currently on the market. This enzyme represents an attractive target for the development of new inhibitors to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa4f4407771ea9aa14698c78569d190
https://doi.org/10.3851/imp1716
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