Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Craig L. Bohrson"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV
Externí odkaz:
https://doaj.org/article/54f9af3e9c6f4cd1836227bb280a51be
Autor:
Javier Ganz, Lovelace J. Luquette, Sara Bizzotto, Craig L. Bohrson, Hu Jin, Michael B. Miller, Zinan Zhou, Alon Galor, Peter J. Park, Christopher A. Walsh
Publikováno v:
bioRxiv
SUMMARYCharacterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed whole-genome sequencing of 71 oligodendro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16532316eb4bf25771b34b73f12639bd
https://doi.org/10.1101/2023.01.14.523958
https://doi.org/10.1101/2023.01.14.523958
Autor:
Lovelace J. Luquette, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Yifan Zhao, Hu Jin, Doga Gulhan, Javier Ganz, Sara Bizzotto, Samantha Kirkham, Tino Hochepied, Claude Libert, Alon Galor, Junho Kim, Michael A. Lodato, Juan I. Garaycoechea, Charles Gawad, Jay West, Christopher A. Walsh, Peter J. Park
Publikováno v:
Nature Genetics, 54(10), 1564-1571. Nature Publishing Group
NATURE GENETICS
Nat Genet
NATURE GENETICS
Nat Genet
Single-cell DNA sequencing data are generated from human neurons using primary template-directed amplification and analyzed using SCAN2, an improved genotyping tool. Indels are enriched in neuronal regulatory elements and may be deleterious. Accurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbfb2ab572d96cf2841204754caaf5d
https://pure.knaw.nl/portal/en/publications/c32b40db-e719-45a1-8319-adee9a8a4292
https://pure.knaw.nl/portal/en/publications/c32b40db-e719-45a1-8319-adee9a8a4292
Autor:
Christopher A. Walsh, Sara Bizzotto, Peter J. Park, Min-Seok Kwon, Craig L. Bohrson, Ryan N. Doan, Sonia N. Kim, Alexej Abyzov, Yanmei Dou, Javier Ganz, Taejeong Bae
Publikováno v:
Science. 371:1249-1253
Mutations provide an enduring record Somatic mutations pepper our cells with change, but because they are not in the germline, they do not propagate to the next generation. Bizzotto et al. leveraged data on the distribution of somatic mutations in ad
Autor:
Ryan N. Doan, Kelly M. Girskis, Rachel E. Rodin, Doga Gulhan, Sonia N. Kim, Craig L. Bohrson, Yanmei Dou, Peter J. Park, Christopher A. Walsh, Alissa M. D'Gama, Maxwell A. Sherman, Lariza M. Rento, Min-Seok Kwon, Ajay Nadig, Lovelace J. Luquette
Publikováno v:
Nat Neurosci
Nature neuroscience
Nature neuroscience
We characterize the landscape of somatic mutations-mutations occurring after fertilization-in the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal cortex from 59 donors with autism spectrum disorder (ASD) and 15 control don
Autor:
Florence Coulet, Jill S. Barnholtz-Sloan, Marc Sanson, Adam Boynton, Aniket Shetty, Yvonne Y. Li, Tracy T. Batchelor, Marine Giry, Garrett M. Frampton, Alexandre Carpentier, Peter J. Park, Franck Bielle, Eudocia Q. Lee, Khê Hoang-Xuan, Jean-Yves Delattre, Leon Taquet, Philippe Cornu, Erell Guillerm, Andrew D. Cherniack, Liam F. Spurr, Robert E. Jones, Mehdi Touat, Rameen Beroukhim, Patrick Y. Wen, J. Bryan Iorgulescu, David Meredith, Kristine Pelton, Caroline Dehais, Radwa Sharaf, Sandro Santagata, Alex Duval, Kenin Qian, Nadia Younan, Florence Laigle-Donadey, Patricia Ho, J Ricardo McFaline-Figueroa, Juliana Bonardi, Mary Jane Lim-Fat, David A. Reardon, Capucine Baldini, Naomi Currimjee, Shakti H. Ramkissoon, Caroline Houillier, Katie Pricola Fehnel, Seth Malinowski, Dimitri Psimaras, Cristina Birzu, Charlotte Bellamy, Isidro Cortes-Ciriano, Keith L. Ligon, Jack Geduldig, Karima Mokhtari, Maite Verreault, Lee A. Albacker, Pratiti Bandopadhayay, Bertrand Mathon, Susan N. Chi, E. Antonio Chiocca, Agusti Alentorn, Dean Pavlick, Frank Dubois, Sangita Pal, Samy Ammari, Brian M. Alexander, Arnab Chakravarti, Azra H. Ligon, Sanda Alexandrescu, Ahmed Idbaih, Frédéric Beuvon, Lakshmi Nayak, Laurent Capelle, Aurélien Marabelle, Daphne A. Haas-Kogan, Raymond Y. Huang, Craig L. Bohrson, Wenya Linda Bi, Ruben Ferrer-Luna, Kin-Hoe Chow
Publikováno v:
Nature
A high tumour mutational burden (hypermutation) is observed in some gliomas1–5; however, the mechanisms by which hypermutation develops and whether it predicts the response to immunotherapy are poorly understood. Here we comprehensively analyse the
Autor:
Peter J. Park, Alon Galor, Christopher A. Walsh, Michael B. Miller, Jay A. A. West, Michael A. Lodato, Craig L. Bohrson, Lovelace J. Luquette, Charles Gawad, Zinan Zhou
Primary template-directed amplification (PTA) is an improved amplification technique for single-cell DNA sequencing. We generated whole-genome analysis of 76 single neurons and developed SCAN2, a computational method to accurately identify both clona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462938ecf2fd00dc4c0e20b315566148
https://doi.org/10.1101/2021.04.30.442032
https://doi.org/10.1101/2021.04.30.442032
Autor:
Theresa Guo, Daria A. Gaykalova, David Sidransky, Elana J. Fertig, Eric J Windsor, Craig L. Bohrson, Wayne M. Koch, Justin A. Bishop, Ludmila Danilova, Joseph A. Califano, Liliana Florea, Sarah J. Wheelan, Christine H. Chung, William H. Westra, Michael Considine, Alexander V. Favorov, Dylan Z. Kelley, Fernando T. Zamuner, Chi Zhang, Emily Flam
Publikováno v:
Translational Research. 202:109-119
We have recently performed the characterization of alternative splicing events (ASEs) in head and neck squamous cell carcinoma, which allows dysregulation of protein expression common for cancer cells. Such analysis demonstrated a high ASE prevalence
Autor:
Sonia N. Kim, Lovelace J. Luquette, Ryan N. Doan, Min-Seok Kwon, Kelly M. Girskis, Rachel E. Rodin, Doga Gulhan, Peter J. Park, Yanmei Dou, Christopher A. Walsh, Maxwell A. Sherman, Alissa M. D'Gama, Lariza M. Rento, Craig L. Bohrson
Although somatic mutations have well-established roles in cancer and certain focal epilepsies, the extent to which mutational mosaicism shapes the developing human brain is poorly understood. Here we characterize the landscape of somatic mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dc655784133dfb53945f2f4ebe5c40
https://doi.org/10.1101/2020.02.11.944413
https://doi.org/10.1101/2020.02.11.944413
Autor:
Christopher A. Walsh, Yanmei Dou, Min-Seok Kwon, Doga Gulhan, Maxwell A. Sherman, Ajay Nadig, Rachel E. Rodin, Lariza M. Rento, Lovelace J. Luquette, Craig L. Bohrson, Sonia N. Kim, Ryan N. Doan, Peter J. Park, Alissa M. D'Gama, Kelly M. Girskis
Publikováno v:
Nature Neuroscience. 24:611-611