Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Craig L, Maynard"'
Autor:
Qing Zhao, Craig L. Maynard
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The immune system in the large intestine is separated from commensal microbes and comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with a compact and adherent inner mucus layer and a looser outer mucus layer. M
Externí odkaz:
https://doaj.org/article/dc6063ee91264d24b169290083e1699e
Autor:
Wenjing Yang, Tianming Yu, Xiangsheng Huang, Anthony J. Bilotta, Leiqi Xu, Yao Lu, Jiaren Sun, Fan Pan, Jia Zhou, Wenbo Zhang, Suxia Yao, Craig L. Maynard, Nagendra Singh, Sara M. Dann, Zhanju Liu, Yingzi Cong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain
Externí odkaz:
https://doaj.org/article/c31a59e08ef446ffa06978b9286f2500
Autor:
Ejas Palathingal Bava, John George, Mohammad Tarique, Srikanth Iyer, Preeti Sahay, Beatriz Gomez Aguilar, Dujon B. Edwards, Bhuwan Giri, Vrishketan Sethi, Tejeshwar Jain, Prateek Sharma, Utpreksha Vaish, Harrys K. C. Jacob, Anthony Ferrantella, Craig L. Maynard, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an antiinflammatory and antifibrotic agent that is approved by the FDA for treatment of idiopa
Externí odkaz:
https://doaj.org/article/5a67edc6225d42e6a846bf7637ca2d15
Autor:
Rachel Q Muir, Barbara J Klocke, Melissa S Jennings, Patrick A Molina, Jung-Shan Hsu, Cailin E Kellum, Katie L Alexander, Goo Lee, Jeremy B Foote, Robin G Lorenz, Jennifer S Pollock, Craig L Maynard
Publikováno v:
Inflammatory Bowel Diseases. 29:960-972
Background Early life stress (ELS) is an environmental trigger believed to promote increased risk of IBD. Our goal was to identify mechanisms whereby ELS in mice affects susceptibility to and/or severity of gut inflammation. Methods We utilized 2 pub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af20c68958d6b9b2adcbef02b06e33c
https://doi.org/10.1093/ibd/izac280
https://doi.org/10.1093/ibd/izac280
Autor:
Virginia Camacho, Victoria R. Matkins, Sweta B. Patel, Jeremie M. Lever, Zhengqin Yang, Li Ying, Ashley E. Landuyt, Emma C. Dean, James F. George, Henry Yang, Paul Brent Ferrell, Craig L. Maynard, Casey T. Weaver, Heth R. Turnquist, Robert S. Welner
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
The nonimmune roles of Tregs have been described in various tissues, including the BM. In this study, we comprehensively phenotyped marrow Tregs, elucidating their key features and tissue-specific functions. We show that marrow Tregs are migratory an
Externí odkaz:
https://doaj.org/article/1f60283a5d9849e4826f16038c6c5f98
Autor:
Dominique C. Hinshaw, Courtney A. Swain, Dongquan Chen, Ann Hanna, Patrick A. Molina, Craig L. Maynard, Goo Lee, Braden C. McFarland, Rajeev S. Samant, Lalita A. Shevde
Publikováno v:
Laboratory Investigation. 102:1236-1244
Given the gut microbiome's rise as a potential frontier in cancer pathogenesis and therapy, leveraging microbial analyses in the study of breast tumor progression and treatment could unveil novel interactions between commensal bacteria and disease ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a459a421b6e540f32717e583a95f1e2
https://doi.org/10.1038/s41374-022-00828-1
https://doi.org/10.1038/s41374-022-00828-1
Autor:
Rachel Quinn Muir, Barbara J. Klocke, Kasi C. McPherson, Jeremy B. Foote, Jennifer S. Pollock, Craig L. Maynard
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 6-7 (2020)
OBJECTIVES/GOALS: The overall goal of this study was to determine the effect of early life stress (ELS) on the intestinal CD4+ T cell immune compartment, at homeostasis and after induction of experimental Inflammatory Bowel Disease (IBD). METHODS/STU
Externí odkaz:
https://doaj.org/article/613a920f56174a28909c3c7dfd0ab03a
Autor:
Yun Kyung Lee, Ashley E Landuyt, Stefani Lobionda, Panida Sittipo, Qing Zhao, Craig L Maynard
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186351 (2017)
The development of Th17 cells is accompanied by the acquisition of responsiveness to both IL-12 and IL-23, cytokines with established roles in the development and/or function of Th1 and Th17 cells, respectively. IL-12 signaling promotes antigen-depen
Externí odkaz:
https://doaj.org/article/0a3cd2029dd545a7920aa129bd83b265
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Exposure to early life stress (ELS) is associated with a greater risk of chronic disease development including depression and cardiovascular disease. Altered gut microbiota has been linked to both depression and cardiovascular disease in mice and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f6ee1ff2b18743116c01346403554f
https://doi.org/10.1152/ajpregu.00072.2020
https://doi.org/10.1152/ajpregu.00072.2020
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a61e92701c6c8499e26f5496b4556a6a
https://doi.org/10.1096/fasebj.2022.36.s1.l8149
https://doi.org/10.1096/fasebj.2022.36.s1.l8149