Zobrazeno 1 - 10
of 19 540
pro vyhledávání: '"Craig L"'
Autor:
Lydia Teboul, James Amos-Landgraf, Fernando J. Benavides, Marie-Christine Birling, Steve D. M. Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L. Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C. Kent Lloyd, Terry R. Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M. J. Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin Peterson, Laura Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C. Bruce Whitelaw, Atsushi Yoshiki, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Guillaume Pavlovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guideline
Externí odkaz:
https://doaj.org/article/81e4d92fe0424d7c9017a0c563ae6724
Publikováno v:
Frontiers in Environmental Science, Vol 12 (2024)
Constructed wetlands are standard conservation practices used to reduce nitrate loads in agricultural watersheds. Many studies have examined the efficiency of denitrification in wetlands under various scenarios, but quantifying the watershed-scale im
Externí odkaz:
https://doaj.org/article/1c4b28c116bb443eb8a966211d87f206
Autor:
Ileana S Mauldin, Craig L Slingluff, Nolan A Wages, Timothy N J Bullock, Remziye E Wessel, Nardin Ageeb, Joseph M Obeid, Kate A Goundry, Gabriel F Hanson, Mahdin Hossain, Chad Lehman, Ryan D Gentzler, Sepideh Dolatshahi, Michael G Brown
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Major histocompatibility complex class I (MHC-I) loss is frequent in non-small cell lung cancer (NSCLC) rendering tumor cells resistant to T cell lysis. NK cells kill MHC-I-deficient tumor cells, and although previous work indicated their
Externí odkaz:
https://doaj.org/article/0caeecd399cd42da95bec43ad9df45a7
Publikováno v:
PeerJ, Vol 12, p e18099 (2024)
The microbiota of hydrothermal vents has been widely implicated in the dynamics of oceanic biogeochemical cycling. Lithotrophic organisms utilize reduced chemicals in the vent effluent for energy, which fuels carbon fixation, and their metabolic bypr
Externí odkaz:
https://doaj.org/article/999a56586a174099ab5e66a925a9a46f
Autor:
Emily K. Ninmer, Hong Zhu, Kimberly A. Chianese-Bullock, Margaret von Mehren, Naomi B. Haas, Merrick I. Ross, Lynn T. Dengel, Craig L. Slingluff
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The critical roles of CD4+ T cells have been understudied for cancer vaccines. Here we report long-term clinical outcomes of a randomized multicenter phase II clinical trial (NCT00118274), where patients with high-risk melanoma received a mu
Externí odkaz:
https://doaj.org/article/8ffd374f530946b7934781dedb085a13
Autor:
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Jo
Externí odkaz:
https://doaj.org/article/620ea33bf16f4f77a76fcba73efa8992
Autor:
Jian Bing, Zhangyue Guan, Tianhong Zheng, Craig L. Ennis, Clarissa J. Nobile, Changbin Chen, Haiqing Chu, Guanghua Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative m
Externí odkaz:
https://doaj.org/article/099b87f379a74efc8a5e94fad6c2fc4e
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Hydrothermal vents host a diverse community of microorganisms that utilize chemical gradients from the venting fluid for their metabolisms. The venting fluid can solidify to form chimney structures that these microbes adhere to and colonize. These ch
Externí odkaz:
https://doaj.org/article/f13a0da6930a4b9cbbb60ce4370ac894
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Publikováno v:
eLife, Vol 13 (2024)
The yeast SWR1C chromatin remodeling enzyme catalyzes the ATP-dependent exchange of nucleosomal histone H2A for the histone variant H2A.Z, a key variant involved in a multitude of nuclear functions. How the 14-subunit SWR1C engages the nucleosomal su
Externí odkaz:
https://doaj.org/article/9557f149d12e46b1a537c93f76e3ca3a