Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Craig K. Docherty"'
Autor:
Craig K. Docherty, Nina Denver, Simon Fisher, Margaret Nilsen, Dianne Hillyard, Rebecca L. Openshaw, Hicham Labazi, Margaret R. MacLean
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 396-405 (2020)
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten
Externí odkaz:
https://doaj.org/article/e5d263e8dc1b4639b7c47108893f55bc
Autor:
Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 217 (2021)
The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM),
Externí odkaz:
https://doaj.org/article/24832a56b1b146b3916302c802e78cef
Autor:
Craig K. Docherty, Jordan Bresciani, Andy Carswell, Amrita Chanderseka, Elaine Friel, Marianna Stasi, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9993 (2021)
DNA damage and mitochondrial dysfunction are defining characteristics of aged vascular smooth muscle cells (VSMCs) found in atherosclerosis. Pink1 kinase regulates mitochondrial homeostasis and recycles dysfunctional organelles critical for maintaini
Externí odkaz:
https://doaj.org/article/05b5d846ea8549f28445a661251b6db4
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 5 (2019)
Background Women are at greater risk of developing pulmonary arterial hypertension, with estrogen and its downstream metabolites playing a potential role in the pathogenesis of the disease. Hypoxia‐inducible factor‐1‐α (HIF1α) is a pro‐prol
Externí odkaz:
https://doaj.org/article/60705a9fce674838a45d67b5e1c30a50
Autor:
Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 217, p 217 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 217
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 217
The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM),
Autor:
John Mercer, Craig K. Docherty, Jordan Bresciani, Andrew Carswell, Amrita Chanderseka, Marianna Stasi, E Friel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9993, p 9993 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
DNA damage and mitochondrial dysfunction are defining characteristics of aged vascular smooth muscle cells (VSMCs) found in atherosclerosis. Pink1 kinase regulates mitochondrial homeostasis and recycles dysfunctional organelles critical for maintaini
Autor:
Margaret R. MacLean, Nina Denver, Rebecca L. Openshaw, Dianne Z. Hillyard, Craig K. Docherty, Margaret Nilsen, Hicham Labazi, Simon Fisher
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 396-405 (2020)
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 396-405 (2020)
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49af2e82db7d961eb98cef09cf0c51a
https://strathprints.strath.ac.uk/75323/1/Docherty_etal_MTNA_2020_Direct_delivery_of_microRNA96_to_the_lungs_reduces_progression.pdf
https://strathprints.strath.ac.uk/75323/1/Docherty_etal_MTNA_2020_Direct_delivery_of_microRNA96_to_the_lungs_reduces_progression.pdf
Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Publikováno v:
D106. PICK YOUR POISON: GENES, DRUGS, AND PAH.
Publikováno v:
C50. THE PERFECT DRUG: EXPERIMENTAL TREATMENTS OF PAH.