Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Craig J. Roxburgh"'
Publikováno v:
Dyes and Pigments. 121:57-72
Isomeric equilbria of dinitro-substituted indolospirobenzopyrans, possessing 3′-gem-methyl- or 3′-cyclohexyl-substitutents, have been investigated using 1H NMR spectroscopy at six temperatures, ranging from 298 K to 410 K; isomerisation processes
Publikováno v:
Dyes and Pigments. 90:146-162
A series of novel 6-nitro substituted indolospirobenzopyrans are reported. The effects of substitution on their photoreversibility are investigated by: synthesising derivatives that possess sterically hindering (with regard to the spiropyran-opening
Publikováno v:
Dyes and Pigments. 83:31-50
Several, novel, 3′-, 5- and 3-substituted indolospirobenzopyrans were prepared and their reversible thermochromic equilibria were investigated by synthesising derivatives with appropriately placed “electronically” modifying substituents in both
Publikováno v:
Dyes and Pigments. 82:226-237
The photoreversibility of several novel indolospirobenzopyrans was investigated using temperature studies – monitored using 1H NMR spectroscopy, qualitative UV studies and acid deuterolysis (trifluorodeuterioacetic acid (TFA-D)) catalysed isomerisa
Publikováno v:
European Journal of Inorganic Chemistry. 2008:4951-4960
The photoreversible transportation of Zn 2+ ions across an interface using photochromic substituted-spirobenzopyrans has been demonstrated. The inclusion of strategically placed sterically influencing 3'-methyl-3b and 3-spirocyclohexyl-3c groupings i
Publikováno v:
Dyes and Pigments. 76:319-326
Following our publication of the synthesis of the new 5-substituted crowned spirocyclic benzopyrans ( 3a – c ), and the fact that suitably placed substituents can be used to influence their metal-ion chelating properties [Roxburgh, CJ, Sammes, PG.
Autor:
Peter G. Sammes, Craig J. Roxburgh
Publikováno v:
European Journal of Organic Chemistry. 2006:1050-1056
The reversible photochemical ion chelation of the newly synthesised substituted N,N′-bis(spiro[1-benzopyran-2,2′-indolyl])diazacrown systems 15a–c and the subsequent molecular electronic control of this process using appropriately placed substi
Autor:
M Malik-Hall, Athmani S, Wilma Quaglia, Charon Robin Ganellin, M A R Shiner, David C. H. Benton, Bisi A, D.G. Haylett, D. H. Jenkinson, Craig J. Roxburgh
Publikováno v:
Journal of Medicinal Chemistry. 44:3244-3253
Cetiedil, [2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1H-azepin-1-yl)ethyl ester], which blocks the intermediate calcium-activated potassium ion permeability (IK(Ca)) in red blood cells, was used as a lead for investigating structure-activi
Publikováno v:
British Journal of Pharmacology. 126:169-178
1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore
Autor:
Craig J. Roxburgh
Publikováno v:
Synthesis. 1996:307-320
The syntheses of potential drug candidates, both old and new, whose mode of action has been found to be via the modulation of potassium channels, are reviewed.