Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Craig J. Morton"'
Autor:
Hunter L. Abrahamsen, Tristan C. Sanford, Casie E. Collamore, Bronte A. Johnstone, Michael J. Coyne, Leonor García-Bayona, Michelle P. Christie, Jordan C. Evans, Allison J. Farrand, Katia Flores, Craig J. Morton, Michael W. Parker, Laurie E. Comstock, Rodney K. Tweten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like (CDCL)
Externí odkaz:
https://doaj.org/article/fa81631103bf486aa966a456bbef1768
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic in
Externí odkaz:
https://doaj.org/article/57a7cb56921f49669d1a14d82f0a823a
Autor:
Caroline Dix, Johannes Zeller, Hannah Stevens, Steffen U. Eisenhardt, Karen S. Cheung Tung Shing, Tracy L. Nero, Craig J. Morton, Michael W. Parker, Karlheinz Peter, James D. McFadyen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation. There is now increasing evidence that CRP is not only a marker of inflamm
Externí odkaz:
https://doaj.org/article/c4240389338e43d6a34173ed2f3b2938
Autor:
Leo Yi Yang Lee, Randy Suryadinata, Conor McCafferty, Vera Ignjatovic, Damian F. J. Purcell, Phil Robinson, Craig J. Morton, Michael W. Parker, Gary P. Anderson, Paul Monagle, Kanta Subbarao, Jessica A. Neil
Publikováno v:
Viruses, Vol 14, Iss 12, p 2620 (2022)
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has proven efficacious for reducing disease severity and virus spread. However, the emergence of highly transmissible viral varia
Externí odkaz:
https://doaj.org/article/da5ad53583874626aa4cd8c4e288da7b
Autor:
Jordan C. Evans, Bronte A. Johnstone, Sara L. Lawrence, Craig J. Morton, Michelle P. Christie, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mechanism is how completion of the prepore is sensed to initiate its conversion to the pore. We identified a moti
Externí odkaz:
https://doaj.org/article/c68956bf53bd4654a2ba9c2e4b08d948
Autor:
Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The N-terminal domain (NTD) of interleukin-3 receptor α-subunit (IL3Rα) is involved in IL-3 recognition but the underlying mechanism is unknown. Here, the authors present crystal structures of the IL3Rα complex and provide biochemical evidence tha
Externí odkaz:
https://doaj.org/article/a177e8976263487282e8d1895527256b
Autor:
David Braig, Tracy L. Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R. Thiele, Craig J. Morton, Johannes Zeller, Jurij Kiefer, Lawrence A. Potempa, Natalie A. Mellett, Luke A. Miles, Xiao-Jun Du, Peter J. Meikle, Markus Huber-Lang, G. Björn Stark, Michael W. Parker, Karlheinz Peter, Steffen U. Eisenhardt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braiget al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead
Externí odkaz:
https://doaj.org/article/128f34d5a0f648b598b01c6bc5aab5a5
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The crystal structures of the soluble monomers of the pore-forming cholesterol-dependent cytolysins (CDCs) contain two α-helical bundles that flank a twisted core β-sheet. This protein fold is the hallmark of the CDCs, as well as of the me
Externí odkaz:
https://doaj.org/article/70c7a6f486474d4393e2f0732710f0ed
Autor:
Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions. U
Externí odkaz:
https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855