Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Craig J. Markin"'
Autor:
Kara Brower, Robert R. Puccinelli, Craig J. Markin, Tyler C. Shimko, Scott A. Longwell, Bianca Cruz, Rafael Gomez-Sjoberg, Polly M. Fordyce
Publikováno v:
HardwareX, Vol 3, Iss , Pp 117-134 (2018)
Microfluidic technologies have been used across diverse disciplines (e.g. high-throughput biological measurement, fluid physics, laboratory fluid manipulation) but widespread adoption has been limited in part due to the lack of openly disseminated re
Externí odkaz:
https://doaj.org/article/c2ebeef00ba34878b2ec942257f44782
Autor:
Polly M. Fordyce, Chiara Sabatti, Daniel A. Mokhtari, Scott A. Longwell, Daniel Herschlag, Mason J. Appel, Eyal Akiva, Fanny Sunden, Craig J. Markin
Go big or you'll get lost Rational mutagenesis is a common approach to investigating or engineering enzyme function in vitro, but the ease with which one can manipulate protein sequences belies many pitfalls in connecting sparse activity data to an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b174ff564afcbe0f4b6ac5f5b291826
https://doi.org/10.1101/2020.11.24.383182
https://doi.org/10.1101/2020.11.24.383182
Publikováno v:
Cell systems. 12(2)
Transcription factors (TFs) bind regulatory DNA to control gene expression, and mutations to either TFs or DNA can alter binding affinities to rewire regulatory networks and drive phenotypic variation. While studies have profiled energetic effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131efeb92ab13419c2ee5a9fa5501355
https://pubmed.ncbi.nlm.nih.gov/33340452
https://pubmed.ncbi.nlm.nih.gov/33340452
SummaryTranscription factors (TFs) bind regulatory DNA to control gene expression, and mutations to either TFs or DNA can alter binding affinities to rewire regulatory networks and drive phenotypic variation. While studies have profiled energetic eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ab98d356465cbd08aa6331d9904903
https://doi.org/10.1101/2020.06.22.165571
https://doi.org/10.1101/2020.06.22.165571
Publikováno v:
The Journal of Physical Chemistry B. 123:776-786
Cullin-RING ubiquitin ligases are a diverse family of ubiquitin ligases that catalyze the synthesis of K48-linked polyubiquitin (polyUb) chains on a variety of substrates, ultimately leading to their degradation by the proteasome. The cullin-RING enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf2258a3910cb6659da81937cfce531
https://doi.org/10.1021/acs.jpcb.8b10706
https://doi.org/10.1021/acs.jpcb.8b10706
Autor:
Daniel A. Mokhtari, Arjun K. Aditham, Polly M. Fordyce, Nicole DelRosso, Craig J. Markin, Connor Horton
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be5ac6b284abd8511c59d67aa0cadbb
https://doi.org/10.1096/fasebj.2020.34.s1.00183
https://doi.org/10.1096/fasebj.2020.34.s1.00183
Autor:
Polly M. Fordyce, Craig J. Markin, Daniel A. Mokhtari, Daniel Herschlag, Fanny Sunden, Mason J. Appel
Publikováno v:
Biophysical Journal. 118:535a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7bdec9b59d0cb32cb27b08383d5308
https://doi.org/10.1016/j.bpj.2019.11.2935
https://doi.org/10.1016/j.bpj.2019.11.2935
Autor:
D McDonald, J. N. Glover, Msy Pulvino, J Zhao, Craig J. Markin, Curtis D. Hodge, Michael J. Hendzel, Msy Huen, Leo Spyracopoulos, Ross A. Edwards
Publikováno v:
ACS Chemical Biology. 10:1718-1728
Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f85a9cfd0cb1ef77984bd394ba3376
https://doi.org/10.1021/acschembio.5b00222
https://doi.org/10.1021/acschembio.5b00222
Autor:
Bianca Cruz, Robert Puccinelli, Craig J. Markin, Scott A. Longwell, Polly M. Fordyce, Rafael Gomez-Sjoberg, Tyler C. Shimko, Kara Brower
Publikováno v:
HardwareX, Vol 3, Iss, Pp 117-134 (2018)
Microfluidic technologies have been used across diverse disciplines (e.g. high-throughput biological measurement, fluid physics, laboratory fluid manipulation) but widespread adoption has been limited due to the lack of openly disseminated resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ef8f250b4a8ce18ca8be505466ca3
Publikováno v:
Journal of Biological Chemistry. 289:12852-12862
Signal transduction within the DNA damage response is driven by the flux of protein-protein interaction cascades that ultimately recruit repair complexes to sites of damage. The protein RAP80 plays a central role in the damage response by targeting B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029facaecccba4340015cc6acd386068
https://doi.org/10.1074/jbc.m113.538280
https://doi.org/10.1074/jbc.m113.538280