Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Craig J. Knight"'
Autor:
Steven J. Fussell, Craig J. Knight, Michael Hawksworth, Daniel Laity, Suju Mathew, Samantha V. Oke, Philip Peach, David S. B. Daniels, Olivier Dirat, Robert Crook, Adam Gymer, Samantha Prior
Publikováno v:
Organic Process Research & Development. 25:2686-2692
A change in facility for the synthesis of the step 2 intermediate for talazoparib tosylate (1·TsOH) required the development of an alternative, intrinsically safer process. Rapid route scouting and...
Publikováno v:
ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5787193472d08ee03b0f22d9d997d4e3
https://doi.org/10.1021/bk-2019-1332.ch007
https://doi.org/10.1021/bk-2019-1332.ch007
Publikováno v:
Organic Process Research & Development. 16:697-703
The development and implementation of a safe and scalable process for the manufacture of corticosteroid PF-4714224 (1) is described. Initial routes used to synthesise analogues from this series directly from fluocinolone acetonide (2) were unsuitable
Autor:
Craig J. Knight, Katie J. W. Proctor, Nicholas Smith, David C. Pryde, Christopher L. Carr, Peter Jones, Gerwyn Bish, Nieves Castro, Hodgson Paul Blaise, Filippo Rota, Frederick Calo, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, Rachel Dixon, Michael Paradowski, Fiona M. Adam, Gemma C. Parsons
Publikováno v:
Organic Process Research & Development. 15:788-796
The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis t
Autor:
Johnson Timothy Allan, Kim Alfonsi, David Austen Perry, Thomas Lee Fevig, Mark H. Stefaniak, Mark A. Nagy, Sandra M. Jennings, H. Peter Kleine, Juan Colberg, Peter J. Dunn, Craig J. Knight
Publikováno v:
Green Chem.. 10:31-36
Influencing and improving the environmental performance of a large multi-national pharmaceutical company can be achieved with the help of electronic education tools, backed up by site champions and strong site teams. This paper describes the developm