Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Craig J. Ceol"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Whole-genome doubling (WGD) commonly occurs in many solid tumors. Here the authors use a zebrafish model of melanoma and in vitro models to show that BRAFV600E induces WGD via inhibition of RhoA and cytokinesis failure.
Externí odkaz:
https://doaj.org/article/310e40fe11654702911f7b011c1df3ce
Autor:
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma
Externí odkaz:
https://doaj.org/article/f742ba331c9e4c36a7f1fe1c4bdef362
Publikováno v:
eLife, Vol 8 (2019)
Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses different
Externí odkaz:
https://doaj.org/article/65cbd0b6410f4c8ea82fd2f3e91e956c
Autor:
William Tyler Frantz, Sharanya Iyengar, James Neiswender, Alyssa Cousineau, René Maehr, Craig J Ceol
Publikováno v:
eLife. 12
Tissue-resident stem and progenitor cells are present in many adult organs, where they are important for organ homeostasis and repair in response to injury. However, the signals that activate these cells and the mechanisms governing how these cells r
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
The receptor tyrosine kinase KIT promotes survival and migration of melanocytes during development, and excessive KIT activity hyperactivates the RAS/MAPK pathway and can drive formation of melanomas, most notably of rare melanomas that occur on vola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9703cc6c948eef6af983a3ceddd13662
https://doi.org/10.1158/0008-5472.c.6510162.v1
https://doi.org/10.1158/0008-5472.c.6510162.v1
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
This file contains Supplementary Figures S1-S9 with accompanying legends. Supplementary Fig. S1 examines the relationship between KIT expression and BRAFV600E mutations in TCGA human melanoma samples. Supplementary Fig. S2 shows the rescue of melanoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0307b9a6fddd3b95f62e590f92256833
https://doi.org/10.1158/0008-5472.22418562.v1
https://doi.org/10.1158/0008-5472.22418562.v1
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
Supplementary Table S1 and S2 show the BRET50 data for Supplementary Fig. S5A and S6B, respectively. Supplementary Table S3 and S4 show further analyses of the relationship between KIT expression and several clinical parameters of melanoma progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40cc3038b2b0c05eb4dd86b5d084880
https://doi.org/10.1158/0008-5472.22418559.v1
https://doi.org/10.1158/0008-5472.22418559.v1
Autor:
William Tyler Frantz, Craig J Ceol
Publikováno v:
Cells, Vol 9, Iss 5, p 1289 (2020)
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish—due in large part t
Externí odkaz:
https://doaj.org/article/0590edd066bc41f38812168aee2b59e6
Autor:
Ze'ev Ronai, Leonard I. Zon, Carmit Levy, Meenhard Herlyn, Marcus Bosenberg, Amanda W. Lund, David B. Lombard, Jean-Christophe Marine, Richard M. White, Yardena Samuels, Charles K. Kaufman, Christin E. Burd, Shaheen Khan, Marc Hurlbert, Kristen L. Mueller, Eleonora Leucci, Andrew E. Aplin, Sheri L. Holmen, Iwei Yeh, Ashani T. Weeraratna, David J. Adams, Martin McMahon, Corine Bertolotto, Florian A. Karreth, Sebastian Kobold, Glenn Merlino, Carla Daniela Robles-Espinoza, Ping Chi, Jessie Villanueva, Niroshana Anandasabapathy, Kerrie L. Marie, Maria S. Soengas, Jiyue Zhu, Richard Marais, Craig J. Ceol, E. Elizabeth Patton
Publikováno v:
Patton, E E, Mueller, K L, Adams, D J, Anandasabapathy, N, Aplin, A E, Bertolotto, C, Bosenberg, M, Ceol, C, Chi, P, Herlyn, M, Holmen, S L, Karreth, F A, Kaufman, C, Khan, S, Kobold, S, Leucci, E, Levy, C, Lombard, D B, Lund, A W, Marie, K L, Marine, J-C, Marais, R, McMahon, M, Robles-Espinoza, C D, Ronai, Z A, Samuels, Y, Soengas, M S, Villanueva, J, Weeraratna, A T, White, R M, Yeh, I, Zhu, J, Zon, L I, Hurlbert, M S & Merlino, G 2021, ' Melanoma Models for the Next Generation of Therapies ', Cancer Cell . https://doi.org/10.1016/j.ccell.2021.01.011
Cancer Cell
Patton, E E, Mueller, K L, Adams, D J, Anandasabapathy, N, Aplin, A E, Bertolotto, C, Bosenberg, M, Ceol, C J, Burd, C E, Chi, P, Herlyn, M, Holmen, S L, Karreth, F A, Kaufman, C K, Khan, S, Kobold, S, Leucci, E, Levy, C, Lombard, D B, Lund, A W, Marie, K L, Marine, J-C, Marais, R, McMahon, M, Robles-Espinoza, C D, Ronai, Z A, Samuels, Y, Soengas, M S, Villanueva, J, Weeraratna, A T, White, R M, Yeh, I, Zhu, J, Zon, L I, Hurlbert, M S & Merlino, G 2021, ' Melanoma models for the next generation of therapies ', Cancer Cell, vol. 39, no. 5, pp. 610-631 . https://doi.org/10.1016/j.ccell.2021.01.011
Cancer Cell
Patton, E E, Mueller, K L, Adams, D J, Anandasabapathy, N, Aplin, A E, Bertolotto, C, Bosenberg, M, Ceol, C J, Burd, C E, Chi, P, Herlyn, M, Holmen, S L, Karreth, F A, Kaufman, C K, Khan, S, Kobold, S, Leucci, E, Levy, C, Lombard, D B, Lund, A W, Marie, K L, Marine, J-C, Marais, R, McMahon, M, Robles-Espinoza, C D, Ronai, Z A, Samuels, Y, Soengas, M S, Villanueva, J, Weeraratna, A T, White, R M, Yeh, I, Zhu, J, Zon, L I, Hurlbert, M S & Merlino, G 2021, ' Melanoma models for the next generation of therapies ', Cancer Cell, vol. 39, no. 5, pp. 610-631 . https://doi.org/10.1016/j.ccell.2021.01.011
Summary There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of novel therapeutic modalities. Here, we discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived