Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Craig J. Burd"'
Autor:
Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of spe
Externí odkaz:
https://doaj.org/article/a16f75dc242345688e57e18ad40b740a
Autor:
Clarissa Wormsbaecher, Andrea R. Hindman, Alex Avendano, Marcos Cortes-Medina, Caitlin E. Jones, Andrew Bushman, Lotanna Onua, Claire E. Kovalchin, Alina R. Murphy, Hannah L. Helber, Ali Shapiro, Kyle Voytovitch, Xingyan Kuang, Renan Aguilar-Valenzuela, Jennifer L. Leight, Jonathan W. Song, Craig J. Burd
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transforma
Externí odkaz:
https://doaj.org/article/06289fcf953349bf8b69644304328452
Autor:
Karen E. Knudsen, Robert L. Sutherland, Susan M. Henshall, Hallgeir Rui, Erik S. Knudsen, Leonard G. Gomella, Raffaele Baffa, Christopher A. Haiman, Laurence N. Kolonel, Loic Le Marchand, Brian E. Henderson, Vanessa M. Hayes, Gianluca Severi, Graham G. Giles, Hoa N. Hoang, Eric M. Groh, Craig J. Burd, Ying Wang, Elizabeth A. Tindall, Fransiscus E. Utama, Thai H. Tran, Jason Karch, Ruth Pe Benito, Michael A. Augello, Clay E.S. Comstock
Purpose: Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686dd86a1010726a10e4e88af9f73abb
https://doi.org/10.1158/1078-0432.c.6517422.v1
https://doi.org/10.1158/1078-0432.c.6517422.v1
Autor:
Karen E. Knudsen, Robert L. Sutherland, Susan M. Henshall, Hallgeir Rui, Erik S. Knudsen, Leonard G. Gomella, Raffaele Baffa, Christopher A. Haiman, Laurence N. Kolonel, Loic Le Marchand, Brian E. Henderson, Vanessa M. Hayes, Gianluca Severi, Graham G. Giles, Hoa N. Hoang, Eric M. Groh, Craig J. Burd, Ying Wang, Elizabeth A. Tindall, Fransiscus E. Utama, Thai H. Tran, Jason Karch, Ruth Pe Benito, Michael A. Augello, Clay E.S. Comstock
Supplementary Data from Cyclin D1 Splice Variants: Polymorphism, Risk, and Isoform-Specific Regulation in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9b4f5ca5156627ed2e5fdb23dfa08c
https://doi.org/10.1158/1078-0432.22440045
https://doi.org/10.1158/1078-0432.22440045
Autor:
Brandon M. Murphy, Daelin M. Jensen, Tiffany E. Arnold, Renan Aguilar-Valenzuela, Jase Hughes, Valentina Posada, Kimberly T. Nguyen, Vi T. Chu, Kenneth Y. Tsai, Craig J. Burd, Christin E. Burd
An increasing number of cancer subtypes are treated with front-line immunotherapy. However, approaches to overcome primary and acquired resistance remain limited. Pre-clinical mouse models are often used to investigate resistance mechanisms, novel dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53aacaac6d874b862ad38ce853ae1ea4
https://doi.org/10.1101/2022.12.09.519766
https://doi.org/10.1101/2022.12.09.519766
Autor:
Tirzah J. Weiss, Emma R. Crawford, Valentina Posada, Hafeez Rahman, Tong Liu, Brandon M. Murphy, Tiffany E. Arnold, Shannon Gray, Zhexuan Hu, Rebecca C. Hennessey, Lianbo Yu, John A. D'Orazio, Craig J. Burd, Jonathan H. Zippin, Douglas Grossman, Christin E. Burd
Publikováno v:
Pigment cellmelanoma researchREFERENCES. 36(1)
Melanin is a free-radical scavenger, antioxidant, and broadband absorber of ultraviolet (UV) radiation which protects the skin from environmental carcinogenesis. However, melanin synthesis and UV-induced reactive melanin species are also implicated i
Publikováno v:
Carcinogenesis
Over 70% of breast cancers express the estrogen receptor (ER) and depend on ER activity for survival and proliferation. While hormone therapies that target receptor activity are initially effective, patients invariably develop resistance which is oft
Autor:
Ross L. Levine, Robert L. Bowman, Brandon M. Murphy, Amy Webb, A. Hunter Shain, Christin E. Burd, Tirzah J Weiss, Souhui Zhang, Craig J. Burd, David Tallman, Rebecca C. Hennessey, Emma R. Crawford, Krista M. D. La Perle
Publikováno v:
Life Science Alliance
A single, neonatal UVB exposure drives greater UV-signature production in Braf- than Nras-mutant murine melanomas.
BRAF-mutant melanomas are more likely than NRAS-mutant melanomas to arise in anatomical locations protected from chronic sun damag
BRAF-mutant melanomas are more likely than NRAS-mutant melanomas to arise in anatomical locations protected from chronic sun damag
Autor:
Clarissa Wormsbaecher, Andrea R. Hindman, Alex Avendano, Marcos Cortes-Medina, Jonathan W. Song, Craig J. Burd
Publikováno v:
Cancer Research. 82:2687-2687
In utero exposure to estrogenic endocrine disrupting compounds (EDCs) increases a woman’s lifetime risk of breast cancer. Similarly, mice exposed in utero to the estrogenic EDC bisphenol A (BPA) have increased susceptibility to mammary gland tumors
Autor:
Michael S Bodnar, Tirzah J Weiss, Min Chen, Craig J. Burd, Vincenzo Coppola, Andrea M. Holderbaum, Marie Fort, Christin E. Burd, Brandon M. Murphy, Aastha Dhakal
Distinct NRAS mutants are enriched in various tumor types. Here, we generated a suite of fully congenic, conditional, Nras knock-in mouse models (LSL-Nras Q61R, -K, -L, -H, -P, -Q; G12D and G13D, -R) to test the hypothesis that melanocyte transformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89966cd9c0b92ed576aeed123a7b5fa2
https://doi.org/10.1101/2021.01.15.426808
https://doi.org/10.1101/2021.01.15.426808