Zobrazeno 1 - 10
of 740
pro vyhledávání: '"Craig J, McClain"'
Autor:
Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer’s disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology in AD progr
Externí odkaz:
https://doaj.org/article/68fececdccb84cc983088b9ee897f11c
Autor:
Kevin Brown, Kyle Funk, Alexa Figueroa Barrientos, Ashly Bailey, Sarah Shrader, Wenke Feng, Craig J. McClain, Zhao-Hui Song
Publikováno v:
Cells, Vol 13, Iss 19, p 1618 (2024)
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that exists in the Cannabis sativa plant. CBD has been found to act on various receptors, including both cannabinoid and non-cannabinoid receptors. In addition, CBD has antioxidant effect
Externí odkaz:
https://doaj.org/article/586e551b8d4041adb2e6c5f0e2adf7f2
Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in Fpr2−/− Mice
Autor:
Josiah E. Hardesty, Jeffrey B. Warner, Daniel W. Wilkey, Brett S. Phinney, Michelle R. Salemi, Michael L. Merchant, Craig J. McClain, Dennis R. Warner, Irina A. Kirpich
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9807 (2024)
Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying mechanisms is s
Externí odkaz:
https://doaj.org/article/3e9fdee8452a48648d33b270aaa38259
Publikováno v:
Nutrients, Vol 16, Iss 13, p 2083 (2024)
The interactions of different dietary doses of copper with fructose contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD) via the gut–liver axis. The underlying mechanisms remain elusive. The aim of this
Externí odkaz:
https://doaj.org/article/5f31f1c0db264b05bf6c01570106579a
Autor:
Leila Gobejishvili, Vatsalya Vatsalya, Diana V. Avila, Yana B. Feygin, Craig J. McClain, Sriprakash Mokshagundam, Shirish Barve
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1227 (2024)
Background: Virtually the entire spectrum of liver disease is observed in association with type 2 diabetes mellitus (T2DM); indeed, T2DM is now the most common cause of liver disease in the U.S. We conducted a pilot study to investigate the relevance
Externí odkaz:
https://doaj.org/article/c61f484e543b4433bd2cec561bb67713
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4836 (2024)
Fatty acid desaturase 1 (FADS1) is a rate-limiting enzyme in long-chain polyunsaturated fatty acid (LCPUFA) synthesis. Reduced activity of FADS1 was observed in metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study w
Externí odkaz:
https://doaj.org/article/23df31f7105e4e72b44ecc4ed7f7968a
Autor:
Vatsalya Vatsalya, Joris C. Verster, Manasa Sagaram, Amor J. Royer, Huirong Hu, Ranganathan Parthasarathy, Melanie L. Schwandt, Maiying Kong, Vijay A. Ramchandani, Wenke Feng, Ruchita Agrawal, Xiang Zhang, Craig J. McClain
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionPatients with alcohol use disorder (AUD) exhibit symptoms such as alcohol withdrawal, depression, and cravings. The gut-immune response may play a significant role in manifesting these specific symptoms associated with AUD. This study exa
Externí odkaz:
https://doaj.org/article/2240cd3a190b486089e9e4241ce71100
Autor:
Wanzhu Tu, Samer Gawrieh, Srinivasan Dasarathy, Mack C. Mitchell, Douglas A. Simonetto, Kavish R. Patidar, Craig J. McClain, Ramon Bataller, Gyongyi Szabo, Qing Tang, Bruce A. Barton, Svetlana Radaeva, Arun J. Sanyal, Vijay Shah
Publikováno v:
Contemporary Clinical Trials Communications, Vol 32, Iss , Pp 101074- (2023)
Background: Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care for patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated inflammation
Externí odkaz:
https://doaj.org/article/4203b99fa20a49bd8563292dfc456ba2
Autor:
Smita S. Ghare, Benjamin T. Charpentier, Dushan T. Ghooray, Jingwen Zhang, Manicka V. Vadhanam, Sreelatha Reddy, Swati Joshi-Barve, Craig J. McClain, Shirish S. Barve
Publikováno v:
Nutrients, Vol 15, Iss 20, p 4397 (2023)
Purpose: Chemokine-driven leukocyte infiltration and sustained inflammation contribute to alcohol-associated liver disease (ALD). Elevated hepatic CCL2 expression, seen in ALD, is associated with disease severity. However, mechanisms of CCL2 regulati
Externí odkaz:
https://doaj.org/article/b36e71d2afe642ff9f75b29c63bbb365
Autor:
Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili
Publikováno v:
Biology, Vol 12, Iss 10, p 1321 (2023)
Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes,
Externí odkaz:
https://doaj.org/article/18569421050f4eb4885efe87cba9f9c4