Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Craig Ivan Turner"'
Autor:
Zhou Wenbin, Mary Brock, Heidi Schilter, Mandar Deodhar, Lara Perryman, Jessica Stolp, Craig Ivan Turner, Dieter Hamprecht, Brett Charlton, Yimin Yao, Wolfgang Jarolimek, Christina Raso, Ross Hamilton, Jonathan Stuart Foot, Marie Galati, Alison D. Findlay, Amna Zahoor
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3de0ce4b9cdc8a367fdf85379b88be7
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
Autor:
Orly Leiva, Alison D. Findlay, Shinobu Matsuura, Vipul C. Chitalia, Hector A. Lucero, Seng Kah Ng, Wolfgang Jarolimek, Katya Ravid, Craig Ivan Turner
Publikováno v:
Int J Hematol
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) that usually portends a poor prognosis with limited therapeutic options available. Currently only allogeneic stem cell transplantation is curative in those who are candidates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6106c3bc6f8f56a4e1b8a78e82cca5a0
https://doi.org/10.1007/s12185-019-02751-6
https://doi.org/10.1007/s12185-019-02751-6
Publikováno v:
Anti-fibrotic Drug Discovery ISBN: 9781788015103
The hallmark of fibrosis is the accumulation of excessive collagen in tissue as a result of an imbalance between collagen formation and degradation. A key step in collagen formation is its stabilization – and with this, slowing of its degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d159c3af0e387ba4e968c189bceb4887
https://doi.org/10.1039/9781788015783-00145
https://doi.org/10.1039/9781788015783-00145
Autor:
Wolfgang Jarolimek, Andrew G. Jarnicki, Heidi Schilter, Jonathan Stuart Foot, Philip M. Hansbro, Craig Ivan Turner, Zhou Wenbin, Mandar Deodhar, Gang Liu, Alison D. Findlay, Alberto Buson
Publikováno v:
Journal of medicinal chemistry. 62(21)
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-links in extracellular matrix proteins, namely, collagen and elastin, and is indicated in fibrotic diseases. Herein, we report the identification and subsequent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75af825d7a51df8d8363f42172222091
https://pubmed.ncbi.nlm.nih.gov/31580073
https://pubmed.ncbi.nlm.nih.gov/31580073
Autor:
Amna Zahoor, Craig Ivan Turner, Heidi Schilter, Greco Angelique Elsa, Joshua Moses, Tin T Yow, Wolfgang Jarolimek, Zhou Wenbin, Mandar Deodhar, Alberto Buson, Sarah Townsend, Lara Perryman, Benjamin S. Rayner, Jonathan Stuart Foot, Alison D. Findlay, Amar Joshi
Publikováno v:
Journal of Cellular and Molecular Medicine
Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function. Lysyl oxidases are key players during this process,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245fc3c8e82e47bdc6eb220ffe538eb3
https://pubmed.ncbi.nlm.nih.gov/30536539
https://pubmed.ncbi.nlm.nih.gov/30536539
Autor:
Heidi Schilter, Alberto Buson, Craig Ivan Turner, Wolfgang Jarolimek, Zhou Wenbin, Mandar Deodhar, Tin T Yow, Lily Guo, Ian A. McDonald, Alison D. Findlay, Jonathan Stuart Foot
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 347(2)
Semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), is a member of the copper-dependent amine oxidase family that is associated with various forms of inflammation and fibrosis. To investigate the therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7e32ac2b8611d88d7d111246c897af
https://pubmed.ncbi.nlm.nih.gov/23943052
https://pubmed.ncbi.nlm.nih.gov/23943052
Autor:
Andrew Holt, Jonathan S. Foot, Craig Ivan Turner, Aldo Olivieri, Ian A. McDonald, Diego Silva, Ellen M. van Dam, Mandar Deodhar, Ping Yin
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
A new class of 3-fluoroallyl amine-based SSAO/VAP-1 inhibitors is reported. These compounds have excellent selectivity over diamine oxidase, MAO-A and MAO-B. Synthesis and SAR studies leading to compound 28 (PXS-4159A) are reported. The pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70da8507dc54027204a56780fa27cf5c
https://pubmed.ncbi.nlm.nih.gov/22595173
https://pubmed.ncbi.nlm.nih.gov/22595173