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The p53 tumor suppressor plays a major role in preventing tumor development by transactivating genes to remove or repair potentially tumorigenic cells. Here we show that the Y-box-binding protein, YB1, acts as a negative regulator of p53. Using repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcb53648fe9d782155d91e125846b50
https://doi.org/10.1074/jbc.m303920200

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Y-box factor YB1 controls p53 apoptotic function

Autor: Annette Lasham, Antony W. Braithwaite, Deborah A Knight, Lynne Hananeia, Philip W. Sheard, Janice A. Royds, Craig Homer, Joanna M. Risk

Publikováno v: Oncogene. 24(56)

Nuclear localization and high levels of the Y-box-binding protein YB1 appear to be important indicators of drug resistance and tumor prognosis. YB1 also interacts with the p53 tumor suppressor protein. In this paper, we have continued to explore YB1/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50a88923bc143668b83ce126193a5fb
https://pubmed.ncbi.nlm.nih.gov/16158057

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Nuclear localization of Y-box factor YB1 requires wild-type p53

Autor: Annette Lasham, Antony W. Braithwaite, Lynne Hananeia, Craig Homer, Janice A. Royds, Philip W. Sheard, You Fang Zhang, Sara J. Edwards

Publikováno v: Oncogene. 22(18)

Nuclear localization and high levels of the Y-box binding protein YB1 appear to be important indicators of drug resistance and tumor prognosis. YB1 also interacts with the p53 tumor suppressor protein. In this paper, we explore a role for p53 in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9cc628eaad36d7001b9a1b9c104eae
https://pubmed.ncbi.nlm.nih.gov/12743601

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Targeting inhibitors of NOD2 signaling to allow productive inflammation in genetic inflammatory disease (157.9)

Autor: Jill Marinis, Craig Homer, Christine McDonald, Derek Abbott

Publikováno v: The Journal of Immunology. 186:157.9-157.9

The intracellular bacterial sensor, NOD2, coordinates innate immune signaling pathways. Maintaining appropriate activation of NOD2 is paramount in immunologic homeostasis as dysregulation of NOD2 signaling causes a variety of inflammatory diseases in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6241c2c6c4bde50e501577cb7d85f48e
https://doi.org/10.4049/jimmunol.186.supp.157.9

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