Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

Autor: John Reardon, J. Craig Hartman, Kefei Zhang, Carlos del Rio, Hani N. Sabbah

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803069b3001ba958ec9683326d90c4ae
https://doi.org/10.1016/j.jacbts.2018.07.003

Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal

Autor: Brian A. Kilburn, Marie van Dijk, Vicki Mazzorana, Craig Hartman, Allerdien Visser, Rani Fritz, Alan D. Bolnick, Leena Kadam, D. Randall Armant, Sascha Drewlo, Chandni Jain, Michael Hertz, Hamid Reza Kohan-Ghadr

Publikováno v: Science Translational Medicine, 8(363):363re4. American Association for the Advancement of Science
Sci Transl Med
Jain, C V, Kadam, L, Van Dijk, M, Kohan-Ghadr, H R, Kilburn, B A, Hartman, C, Mazzorana, V, Visser, A, Hertz, M, Bolnick, A D, Fritz, R, Armant, D R & Drewlo, S 2016, ' Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal ', Science Translational Medicine, vol. 8, no. 363, 363re4 . https://doi.org/10.1126/scitranslmed.aah4661

Single-gene mutations account for more than 6000 diseases, 10% of all pediatric hospital admissions, and 20% of infant deaths. Down syndrome and other aneuploidies occur in more than 0.2% of births worldwide and are on the rise because of advanced re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f65c721c5347939dcaf3d775605f94b
https://doi.org/10.1126/scitranslmed.aah4661

Abstract 18092: Nitroxyl (HNO) Improves Ventricular Relaxation and Ca2+-Handling in Rats with Induced Chronic Diastolic Dysfunction

Autor: Steve R Roof, Craig Hartman, John Reardon, Carlos del Rio, Mark Ziolo, Robert Hamlin

Publikováno v: Circulation. 130

Despite the morbidity and clinical burden of primary diastolic cardiac dysfunction, effective therapies for patients presenting with heart failure with preserved ejection fraction (HFpEF) are limited. Nitroxyl (HNO) produces cAMP-independent function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdff2b432aa4dbe3f1183e85e460c2ab
https://doi.org/10.1161/circ.130.suppl_2.18092

Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1

Autor: William R. Humphrey, Caryl L. Lane, Donald C. Anderson, Theron M. Wall, Ronald J. Shebuski, J. Craig Hartman, Ann L. Wiltse, Anthony M. Manning, Craig L. Rosenbloom

Publikováno v: Cardiovascular Research. 30:47-54

Objective: A blocking monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1), CL18/6, previously has been demonstrated to inhibit neutrophil attachment to isolated vascular endothelium and cardiomyocytes. Due to the well known participatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::755d92ac596f7da18ae272d66eeedfdf
https://doi.org/10.1016/s0008-6363(95)00015-1

In vivo validation of a transit-time ultrasonic volume flow meter

Autor: Thomas G. Hullinger, Douglas A. Olszanski, Marshall N. Brunden, J. Craig Hartman

Publikováno v: Journal of Pharmacological and Toxicological Methods. 31:153-160

The objective of this investigation was to validate a transit-time ultrasound blood flow metering system in vivo. Implanted chronically and acutely on the ascending aorta of the dog, the transit-time flow probe determined varying flow rates simultane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b255069b8e41626dd816220fae7b6
https://doi.org/10.1016/1056-8719(94)90078-7