CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction—A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat

Autor: Steve R. Roof, Yukie Ueyama, Reza Mazhari, Robert L. Hamlin, J. Craig Hartman, Mark T. Ziolo, John E. Reardon, Carlos L. del Rio

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. Thi

Externí odkaz: https://doaj.org/article/3b8b471a543e49efbf76a4770d5c30ff

Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

Autor: John Reardon, J. Craig Hartman, Kefei Zhang, Carlos del Rio, Hani N. Sabbah

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803069b3001ba958ec9683326d90c4ae
https://doi.org/10.1016/j.jacbts.2018.07.003

Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal

Autor: Brian A. Kilburn, Marie van Dijk, Vicki Mazzorana, Craig Hartman, Allerdien Visser, Rani Fritz, Alan D. Bolnick, Leena Kadam, D. Randall Armant, Sascha Drewlo, Chandni Jain, Michael Hertz, Hamid Reza Kohan-Ghadr

Publikováno v: Science Translational Medicine, 8(363):363re4. American Association for the Advancement of Science
Sci Transl Med
Jain, C V, Kadam, L, Van Dijk, M, Kohan-Ghadr, H R, Kilburn, B A, Hartman, C, Mazzorana, V, Visser, A, Hertz, M, Bolnick, A D, Fritz, R, Armant, D R & Drewlo, S 2016, ' Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal ', Science Translational Medicine, vol. 8, no. 363, 363re4 . https://doi.org/10.1126/scitranslmed.aah4661

Single-gene mutations account for more than 6000 diseases, 10% of all pediatric hospital admissions, and 20% of infant deaths. Down syndrome and other aneuploidies occur in more than 0.2% of births worldwide and are on the rise because of advanced re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f65c721c5347939dcaf3d775605f94b
https://doi.org/10.1126/scitranslmed.aah4661

Abstract 13228: Nitroxyl (HNO) donated via Slow-Release Oral Pro-Drug Improves Ventriculo-Arterial Coupling in Conscious Dogs with Induced Heart Failure: Enhanced Load-Independent Mechano-Energetics

Autor: Carlos L del Rio, Robert S George, Bradley L Youngblood, Yukie Ueyama, Jonelle R May, David J Humphries, Craig Hartman, Doris F Cully, Robert L Hamlin, John E Reardon

Publikováno v: Circulation. 130

Introduction: Reduction of myocardial loading and energetic demand while enhancing function are primary needs for the treatment of heart failure (HF). Nitroxyl (HNO) produces cAMP-independent unloading and inotropic/lusitropic support in both laborat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::456207ffa2c2ceff7c9132f0ec38d726
https://doi.org/10.1161/circ.130.suppl_2.13228

Section Review Cardiovascular & Renal: Bradykinin degradation: potential pathways for cardiovascular therapeutic use

Autor: John A. Schriefer, J Craig Hartman

Publikováno v: Expert Opinion on Investigational Drugs. 5:1465-1476

Bradykinin (BK) is a widely distributed nine amino acid peptide with potent cardiovascular effects. Physiologically, BK has a very brief duration of action due to rapid metabolism by a number of widely distributed enzymes, including carboxypeptidase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f30610dd9dd799ec229024c341701cf
https://doi.org/10.1517/13543784.5.11.1465