Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Craig H. Gelband"'
Publikováno v:
Scopus-Elsevier
This study examines the angiotensin II (Ang II) regulation of intracellular free calcium concentration ([Ca 2+ ] i ) in astroglia cultured from the hypothalamus and brainstem of the adult rat. Bath perfusion or rapid puffer application of angiotensin
Autor:
Jenafer Evans, Gerry Shaw, Craig H. Gelband, Jennifer M. Moore, Colin Sumners, Jie Deng, Matthew J. Huentelman
Publikováno v:
Journal of Neurophysiology. 87:1076-1085
Embryonic or neonatal rat neurons retain plasticity and are readily grown in tissue culture, but neurons of the adult brain were thought to be terminally differentiated and therefore difficult to culture. Recent studies, however, suggest that it may
Autor:
Michael A. Moore, Kathleen W. Sellers, Craig H. Gelband, Mohan K. Raizada, Michael J. Katovich
Publikováno v:
The American Journal of the Medical Sciences. 322:1-6
Hypertension is a complex pathophysiological state that leads to serious complications, including heart failure, coronary artery disease, and abnormal renal function. While traditional therapies can be effective in controlling the effects of hyperten
Publikováno v:
American Journal of Physiology-Renal Physiology. 281:F48-F55
The purpose of this study was to examine cation channel activity in the apical membrane of the outer medullary collecting duct of the inner stripe (OMCDi) using the patch-clamp technique. In freshly isolated and lumen-opened rabbit OMCDi, we have obs
Publikováno v:
American Journal of Physiology-Cell Physiology. 281:C17-C23
It was previously determined that ANG II and phorbol esters inhibit Kv current in neurons cultured from newborn rat hypothalamus and brain stem in a protein kinase C (PKC)- and Ca2+-dependent manner. Here, we have further defined this signaling pathw
Publikováno v:
Scopus-Elsevier
Previously, we determined that angiotensin II (Ang II) elicits an Ang II type 2 (AT2) receptor–mediated increase of neuronal delayed rectifier K+( I KV) current in neuronal cultures from newborn rat hypothalamus and brain stem. This requires genera
Autor:
Craig H. Gelband, Michael J. Katovich, Mohan K. Raizada, Sharon C. Francis, Matthew J. Huentelman, Alok S. Pachori
Publikováno v:
Hypertension. 37:357-364
Hypertension is a debilitating disease with significant socioeconomic and emotional impact. Despite recent success in the development of traditional pharmacotherapy for the management of hypertension, the incidence of this disease is on the rise and
Publikováno v:
An Introduction to Molecular Medicine and Gene Therapy
Cardiovascular disease is the leading cause of mortality and morbidity in developed countries. Most conventional therapy is often inefficacious and tends to treat the symptoms rather than the underlying causes of the disorder. Gene therapy offers a n
Publikováno v:
Circulation Research. 87:1118-1122
Abstract —Systemic hypertension is a pathophysiological state that is manifested as high blood pressure and is a major risk factor for stroke, ischemic heart disease, peripheral vascular disease, and progressive renal damage. Pulmonary hypertension
Publikováno v:
Methods. 22:211-218
Despite recent strides in the traditional pharmacological therapies in the control and management of hypertension, a successful prevention and cure for this disease by conventional drug strategy remain at a standstill. We have begun to investigate th