Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Craig H, Kerr"'
Autor:
Naomi R. Genuth, Zhen Shi, Koshi Kunimoto, Victoria Hung, Adele F. Xu, Craig H. Kerr, Gerald C. Tiu, Juan A. Oses-Prieto, Rachel E. A. Salomon-Shulman, Jeffrey D. Axelrod, Alma L. Burlingame, Kyle M. Loh, Maria Barna
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How ribosomes differ in composition and function to regulate gene expression is poorly understood. Here, the authors show that ribosome composition changes during stem cell differentiation and identify a ribosomal protein that regulates production of
Externí odkaz:
https://doaj.org/article/a6cf4298de7147c5aaf405ad37df4aa1
Autor:
Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang, Hannah K. Wayment-Steele, Craig H. Kerr, Adele F. Xu, Do Soon Kim, Ved V. Topkar, Christian Choe, Daphna Rothschild, Gerald C. Tiu, Roger Wellington-Oguri, Kotaro Fujii, Eesha Sharma, Andrew M. Watkins, John J. Nicol, Jonathan Romano, Bojan Tunguz, Fernando Diaz, Hui Cai, Pengbo Guo, Jiewei Wu, Fanyu Meng, Shuai Shi, Eterna Participants, Philip R. Dormitzer, Alicia Solórzano, Maria Barna, Rhiju Das
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors develop an RNA sequencing-based platform, PERSIST-seq, to simultaneously delineate in-cell mRNA stability, ribosome load, and in-solution stability of a diverse mRNA library to derive design principles for improved mRNA therapeutics.
Externí odkaz:
https://doaj.org/article/2d3b8c62fa5e4b1aa2f3fa11c8674939
Autor:
Craig H. Kerr, Michael A. Skinnider, Daniel D. T. Andrews, Angel M. Madero, Queenie W. T. Chan, R. Greg Stacey, Nikolay Stoynov, Eric Jan, Leonard J. Foster
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)
Abstract Background The type I interferon (IFN) response is an ancient pathway that protects cells against viral pathogens by inducing the transcription of hundreds of IFN-stimulated genes. Comprehensive catalogs of IFN-stimulated genes have been est
Externí odkaz:
https://doaj.org/article/1b2da6d50cbd45098eed91a00d179461
Autor:
Michael Luke Carlson, R Greg Stacey, John William Young, Irvinder Singh Wason, Zhiyu Zhao, David G Rattray, Nichollas Scott, Craig H Kerr, Mohan Babu, Leonard J Foster, Franck Duong Van Hoa
Publikováno v:
eLife, Vol 8 (2019)
Protein-correlation-profiling (PCP), in combination with quantitative proteomics, has emerged as a high-throughput method for the rapid identification of dynamic protein complexes in native conditions. While PCP has been successfully applied to solub
Externí odkaz:
https://doaj.org/article/12c2c88083034a28aa52fd5c18552780
Autor:
Nitin Raj, Mengxiong Wang, Jose A. Seoane, Richard L. Zhao, Alyssa M. Kaiser, Nancie A. Moonie, Janos Demeter, Anthony M. Boutelle, Craig H. Kerr, Abigail S. Mulligan, Clare Moffatt, Shelya X. Zeng, Hua Lu, Maria Barna, Christina Curtis, Howard Y. Chang, Peter K. Jackson, Laura D. Attardi
Publikováno v:
Mol Cell
The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53 regulates gene expression using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fcf0667d8da72f08b88a03fd3626b9
https://europepmc.org/articles/PMC9807187/
https://europepmc.org/articles/PMC9807187/
The ProQ protein interacts as an RNA chaperone with diverse RNA molecules in Escherichia coli. ProQ is implicated in the bacterial osmotic stress response. When the osmotic pressure is high, cells maintain their hydration by accumulating organic solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c9d0f9d1dbbdc40963fd9c01577a29
https://doi.org/10.1101/2022.03.01.481631
https://doi.org/10.1101/2022.03.01.481631
Autor:
Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang, Hannah K. Wayment-Steele, Craig H. Kerr, Adele F. Xu, Do Soon Kim, Ved V. Topkar, Christian Choe, Daphna Rothschild, Gerald C. Tiu, Roger Wellington-Oguri, Kotaro Fujii, Eesha Sharma, Andrew M. Watkins, John J. Nicol, Jonathan Romano, Bojan Tunguz, Fernando Diaz, Hui Cai, Pengbo Guo, Jiewei Wu, Fanyu Meng, Shuai Shi, Eterna Participants, Philip R. Dormitzer, Alicia Solórzano, Maria Barna, Rhiju Das
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we describe design principles that overc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47628809087fae739f01637f739d8ab
https://pubmed.ncbi.nlm.nih.gov/35318324
https://pubmed.ncbi.nlm.nih.gov/35318324
Autor:
Anna Prudova, Queenie W.T. Chan, Nikolay Stoynov, R. Greg Stacey, Craig H. Kerr, Nichollas E. Scott, Leonard J. Foster, Michael A. Skinnider, David G Rattray, Jörg Gsponer
Publikováno v:
SSRN Electronic Journal.
Cellular processes arise from the dynamic organization of proteins in networks of physical interactions. Mapping the complete interactome, has therefore been a central objective of high-throughput biology. However, interaction dynamics across physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82aa00ee878548b9a68da514f1c54170
https://doi.org/10.2139/ssrn.3770938
https://doi.org/10.2139/ssrn.3770938
Autor:
Anthony Khong, Jennifer M. Bonderoff, Ruth V. Spriggs, Erik Tammpere, Craig H. Kerr, Thomas J. Jackson, Anne E. Willis, Eric Jan
Publikováno v:
Viruses, Vol 8, Iss 1, p 25 (2016)
Internal ribosome entry is a key mechanism for viral protein synthesis in a subset of RNA viruses. Cricket paralysis virus (CrPV), a member of Dicistroviridae, has a positive-sense single strand RNA genome that contains two internal ribosome entry si
Externí odkaz:
https://doaj.org/article/6e7493f4e4a24b81b9c9f78f2848ff92
Autor:
Hannah D. Rosenblatt, Laura D. Attardi, Leila Shokat, Maria Barna, Craig H. Kerr, Margot E. Bowen, Pallavi S. Krishnarao, Davide Ruggero, Gerald C. Tiu, Olena Zhulyn, Nitin Raj, Craig M. Forester
SUMMARYIn ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes, such as limb and craniofacial defects as well as bone marrow failure. What accounts for such tissue-selective manifestations as a result of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d9905ebf4848557de806b64cbf215f8
https://doi.org/10.1101/2020.06.24.167940
https://doi.org/10.1101/2020.06.24.167940