Výsledky vyhledávání - "Craig Freeman"

Akademický článek

Neutralizing the pathological effects of extracellular histones with small polyanions

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp

Externí odkaz: https://doaj.org/article/47652de3a653433fb4ea511fb90437ea

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Akademický článek

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

Autor: Charmaine J Simeonovic, Sarah K Popp, Lora M Starrs, Debra J Brown, Andrew F Ziolkowski, Barbara Ludwig, Stefan R Bornstein, J Dennis Wilson, Alberto Pugliese, Thomas W H Kay, Helen E Thomas, Thomas Loudovaris, Fui Jiun Choong, Craig Freeman, Christopher R Parish

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191360 (2018)

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted

Externí odkaz: https://doaj.org/article/3bfbd0d7d48b4557a8441d019c004f28

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Akademický článek

Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

Autor: Hao Cui, Amos C Hung, David W Klaver, Toshiharu Suzuki, Craig Freeman, Christian Narkowicz, Glenn A Jacobson, David H Small

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e23007 (2011)

BackgroundAlzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight f

Externí odkaz: https://doaj.org/article/eda00fd627b64d1b93cb1126837c49bd

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