Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Craig Fancourt"'
Autor:
Marita Prohn, Anders Viberg, Da Zhang, Kevin Dykstra, Casey Davis, Sreeraj Macha, Philip Sabato, Dinesh deAlwis, Marian Iwamoto, Craig Fancourt, Carolyn R. Cho
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 255-267 (2021)
Abstract Letermovir is indicated for prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Two‐stage population pharmacokinetic (PK) modeling of letermovir was conducted to support
Externí odkaz:
https://doaj.org/article/6266540773034cbfab636e1891cbf5e5
Autor:
Kazuhiko, Asari, Mikio, Ishii, Hiroyuki, Yoshitsugu, Akira, Wakana, Craig, Fancourt, Esther, Yoon, Kenichi, Furihata, Jacqueline B, McCrea, S Aubrey, Stoch, Marian, Iwamoto
Publikováno v:
Clinical Pharmacology in Drug Development. 11:938-948
Letermovir is a human cytomegalovirus terminase inhibitor for the prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant recipients. The pharmacokinetics, safety, and tolerability of letermovir were asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955bdece8996fbe2a3a102074b6316ee
https://doi.org/10.1002/cpdd.1081
https://doi.org/10.1002/cpdd.1081
Autor:
Jacqueline B. McCrea, Karsten Menzel, Craig Fancourt, Rose Witter, Tian Zhao, Jonathan A. Robbins, S. Aubrey Stoch, Marian Iwamoto
Publikováno v:
British Journal of Clinical Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee250d387be2feea885d36e641eaf58d
https://doi.org/10.1111/bcp.15677
https://doi.org/10.1111/bcp.15677
Autor:
Karsten Menzel, Jacqueline B. McCrea, Craig Fancourt, Rose Witter, Tian Zhao, S. Aubrey Stoch, Marian Iwamoto
Publikováno v:
British journal of clinical pharmacology.
Letermovir inhibits renal tubular organic anion transporter (OAT)3 in vitro and is predicted to inhibit OAT3 in vivo. Acyclovir, a substrate for OAT3, is likely to be co-administered with letermovir; therefore, letermovir may increase acyclovir conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d6077a0a0dfaa1b64a10747a287c05
https://pubmed.ncbi.nlm.nih.gov/36537620
https://pubmed.ncbi.nlm.nih.gov/36537620
Autor:
Randi Y. Leavitt, Anders Viberg, Carolyn R. Cho, Craig Fancourt, Julie A. Stone, Sreeraj Macha, Yoshihiko Murata, Marita Prohn, Cyrus Badshah, Philip Sabato, Kevin Dykstra, Casey Davis
Publikováno v:
Clinical Pharmacology & Therapeutics. 111:485-495
The cytomegalovirus (CMV) viral terminase inhibitor letermovir is approved for prophylaxis of CMV infection and disease in adult CMV-seropositive allogeneic hematopoietic stem cell transplantation recipients. In a phase III trial (NCT02137772), leter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe4008fba73a1a300982aed78a27fdc
https://doi.org/10.1002/cpt.2456
https://doi.org/10.1002/cpt.2456
Publikováno v:
Clinical Pharmacology and Therapeutics
A model-informed drug discovery and development strategy played a key role in the novel glucose-responsive insulin MK-2640's early clinical development strategy and supported a novel clinical trial paradigm to assess glucose responsiveness. The devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153380340c63932bd8745f0ccef033be
https://doi.org/10.1002/cpt.1729
https://doi.org/10.1002/cpt.1729
Autor:
Jonathan A. Robbins, Karsten Menzel, Michael Lassman, Tian Zhao, Craig Fancourt, Xiaoyan Chu, Kate Mostoller, Rose Witter, Rachel Marceau West, S. Aubrey Stoch, Jacqueline B. McCrea, Marian Iwamoto
Publikováno v:
Clinical pharmacology and therapeutics. 111(3)
Rifampin has acute inhibitory and chronic inductive effects that can cause complex drug-drug interactions. Rifampin inhibits transporters including organic-anion-transporting polypeptide (OATP)1B and P-glycoprotein (P-gp), and induces enzymes and tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a23c659a1834910d2214932ed5305b
https://pubmed.ncbi.nlm.nih.gov/34888851
https://pubmed.ncbi.nlm.nih.gov/34888851
Autor:
Sreeraj Macha, Neeraj Gupta, Craig Fancourt, Satyaprakash Nayak, Dean Bottino, Theodore R. Rieger, Marylore Chenel, Jitendra Kanodia, Ulrika S. H. Simonsson, Tjerk Bueters, Cynthia J. Musante
Publikováno v:
Clinical Pharmacology & Therapeutics. 107:1285-1289
Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a031fbb00c540969c3b040462007224a
https://doi.org/10.1002/cpt.1667
https://doi.org/10.1002/cpt.1667
Autor:
Carolyn R. Cho, Sreeraj Macha, Anders Viberg, Philip Sabato, Marian Iwamoto, Casey Davis, Da Zhang, Dinesh P. de Alwis, Kevin Dykstra, Craig Fancourt, Marita Prohn
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 255-267 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 255-267 (2021)
Letermovir is indicated for prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Two‐stage population pharmacokinetic (PK) modeling of letermovir was conducted to support dose rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adaaff6709665bea16013469ba79ad8
https://pubmed.ncbi.nlm.nih.gov/33440077
https://pubmed.ncbi.nlm.nih.gov/33440077
Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants
Autor:
Deborah Panebianco, Tian Zhao, Marian Iwamoto, Charles Tomek, Karsten Menzel, S. Aubrey Stoch, Adedayo Adedoyin, Craig Fancourt, Jacqueline B. McCrea
Publikováno v:
Clinical pharmacology in drug developmentReferences. 10(2)
Letermovir is a prophylactic agent for cytomegalovirus infection and disease in adult cytomegalovirus-seropositive recipients of allogeneic hematopoietic stem cell transplant. As the antifungal agent fluconazole is administered frequently in transpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdf44602ad516ef50d6e5d99f48be44
https://pubmed.ncbi.nlm.nih.gov/32700459
https://pubmed.ncbi.nlm.nih.gov/32700459