Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Craig E. Masse"'
Autor:
Silvana Leit, Jeremy R. Greenwood, Sayan Mondal, Samantha Carriero, Markus Dahlgren, Geraldine C. Harriman, Joshua J. Kennedy-Smith, Rosana Kapeller, Jon P. Lawson, Donna L. Romero, Angela V. Toms, Mee Shelley, Ronald T. Wester, William Westlin, Joshua J. McElwee, Wenyan Miao, Scott D. Edmondson, Craig E. Masse
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
TYK2 is a member of the JAK family of kinases and a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines have been implicated in the pathogenesis of multiple inflammatory and autoimmune diseases such as psoriasis, rheumatoid
Autor:
Byungchan Kim, Jeremy R. Greenwood, Matt Wirtala, Sayan Mondal, Gary Tresadern, Robert Abel, Thomas Steinbrecher, Craig E. Masse, Joe Kaus, Ramy Farid, Lingle Wang
Optimizing the solubility of small molecules is important in a wide variety of contexts, including in drug discovery where the optimization of aqueous solubility is often crucial to achieve oral bioavailability. In such a context, solubility optimiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a58a17bf37e15beebc229506dab5a46
https://doi.org/10.26434/chemrxiv.10263077
https://doi.org/10.26434/chemrxiv.10263077
Autor:
Yuqing Deng, Edward Harder, Lingle Wang, Bruce J. Berne, Ramy Farid, Ron Wester, Richard A. Friesner, Levi C. T. Pierce, Teng-Yi Lin, Donna L. Romero, William L. Jorgensen, Mark L. Brewer, Murcko Mark A, Shaughnessy Robinson, Robert Abel, Jeremy R. Greenwood, Jennifer L. Knight, Thijs Beuming, Byungchan Kim, Goran Krilov, Leah L. Frye, Dmitry Lupyan, David L. Mobley, Wolfgang Damm, Yujie Wu, Thomas Steinbrecher, Craig E. Masse, Markus K. Dahlgren, Woody Sherman
Publikováno v:
Journal of the American Chemical Society, vol 137, iss 7
Wang, L; Wu, Y; Deng, Y; Kim, B; Pierce, L; Krilov, G; et al.(2015). Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field. Journal of the American Chemical Society, 137(7), 2695-2703. doi: 10.1021/ja512751q. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5061663w
Wang, L; Wu, Y; Deng, Y; Kim, B; Pierce, L; Krilov, G; et al.(2015). Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field. Journal of the American Chemical Society, 137(7), 2695-2703. doi: 10.1021/ja512751q. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5061663w
© 2015 American Chemical Society. Designing tight-binding ligands is a primary objective of small-molecule drug discovery. Over the past few decades, free-energy calculations have benefited from improved force fields and sampling algorithms, as well
Autor:
Jennifer Rocnik, Koshi Akahane, Craig E. Masse, David M. Weinstock, Jeremy R. Greenwood, Takaomi Sanda, Zhaodong Li, Wenyan Miao, Hong L. Tiv, Rosana Kapeller, Evisa Gjini, Julia Etchin, A. Thomas Look, Alla Berezovskaya
Activation of tyrosine kinase 2 (TYK2) contributes to the aberrant survival of T-cell acute lymphoblastic leukaemia (T-ALL) cells. Here we demonstrate the anti-leukaemic activity of a novel TYK2 inhibitor, NDI-031301. NDI-031301 is a potent and selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2108955c41be4e1418f71b5af0cc5661
https://europepmc.org/articles/PMC5384871/
https://europepmc.org/articles/PMC5384871/
Autor:
Kui Chen, Daniel La, Michael D. Bartberger, Russell Graceffa, Thomas T. Nguyen, Tisha San Miguel, E. Allen Sickmier, Ryan Brown, Vivian S. W. Li, Stephen J. Wood, Lewis D. Pennington, James Brown, Jianhua Zhang, Craig E. Masse, Holger Monenschein, Patricia Lopez, Dean Hickman, Brian K. Albrecht, May Xue, Michael Croghan, Scott Harried, Safura Babu-Khan, Yuan Cheng, Yi Luo, Martin Citron, Matthew R. Kaller, Patricia Amarante, Wenge Zhong, Paul H. Wen, Bryant Yang, Robert C. Wahl, Matthew Weiss, Chuck Kriemen, Stephen Hitchcock, Vinod F. Patel, Ted Judd, Toni Williamson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:886-891
β-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in hydroxyethylamine-derived inhibitors such as 1 with low nanomolar potency against β-site amyloid precur
Publikováno v:
Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs
Autor:
Craig E. Masse, Adam J. Morgan, Gary W. Bridson, Vinita Uttamsingh, Roger D. Tung, Sophia Nguyen, Scott L. Harbeson
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:613-624
As part of an ongoing effort to apply the Deuterated Chemical Entity Platform (DCE Platform™) to clinically validated drugs,the synthesis of deuterated analogs of the hepatitis C virus protease inhibitor boceprevir was carried out. The devisedsynth
Autor:
Vadim Molodtsov, David C. McKinney, Paul Robert Fleming, Andrew D. Ferguson, Craig E. Masse, Charles J. Eyermann, Ed T. Buurman, Katsuhiko S. Murakami, Melinda A. Foulk
Squaramides constitute a novel class of RNA polymerase inhibitors of which genetic evidence and computational modeling previously have suggested an inhibitory mechanism mediated by binding to the RNA polymerase switch region. An iterative chemistry p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2deaa42b28ed498ea60e8a5991c5254
https://europepmc.org/articles/PMC4658208/
https://europepmc.org/articles/PMC4658208/
Autor:
Joseph L. Kim, Xiaotian Zhu, William H. Buckner, Josie H. Lee, Vinod F. Patel, Lilly Chai, Antonio J. Oliveira-dos-Santos, Ryan White, Holly L. Deak, Brian L. Hodous, Joseph J. Nunes, John L. Buchanan, Paul E. Rose, Huilin Zhao, Andrew A. Welcher, Stephanie D. Geuns-Meyer, Linda F. Epstein, David Powers, Yan Gu, Stephen Schneider, Kurt Morgenstern, Anu Gore, Victor J. Cee, Yanyan Tudor, Ted Faust, Susan A. Tomlinson, Xin Huang, Erin F. DiMauro, Jean Bemis, Susan M. Turci, John Newcomb, David C. Mcgowan, Faye Hsieh, Brad Henkle, Deanna Mohn, Christina Boucher, Li Zhu, Matthew W. Martin, Paul Gallant, Craig E. Masse, Daniela Metz
Publikováno v:
Journal of Medicinal Chemistry. 49:5671-5686
The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling media
Publikováno v:
Journal of Combinatorial Chemistry. 8:293-296