Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Craig D. Wegner"'
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Akademický článek
A public–private collaboration model for clinical innovation
Autor: Craig D. Wegner, Bobbie Ann Mount, Christine M. Colvis
Publikováno v: Clinical and Translational Science, Vol 15, Iss 7, Pp 1581-1591 (2022)
Abstract Launched in May 2012 as part of the New Therapeutic Uses program, the National Center for Advancing Translational Sciences (NCATS)’ National Institutes of Health (NIH)‐Industry Partnerships initiative fostered collaboration between pharm
Externí odkaz: https://doaj.org/article/880987c003fc4eb1b8e4654fcf94865f
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Effect of Colchicine on Clostridium Difficile Infection Incidence, Recurrence, and Severity
Autor: Peter D. Mills, Yinong Young-Xu, Rahul Kakkar, Craig D. Wegner
Publikováno v: Infectious Diseases in Clinical Practice. 23:141-147
ObjectiveThe objective of this study was to determine the impact of colchicine use on the incidence, recurrence, and severity of Clostridium difficile infections (CDIs).DesignThis was a retrospective cohort analysis of data extracted from a large ele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::933af80fb298ae1cc7e0a71fcc874505
https://doi.org/10.1097/ipc.0000000000000246
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4
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
Autor: Craig D. Wegner, Paul Morgan, Kira S. Drummond, Piet H. van der Graaf, Doug Feltner, Steve D.A. Street, John Edmund Arrowsmith
Publikováno v: Drug Discovery Today. 17:419-424
In an effort to uncover systematic learnings that can be applied to improve compound survival, an analysis was performed on data from Phase II decisions for 44 programs at Pfizer. It was found that not only were the majority of failures caused by lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84073490bb0983834aa8a6d74409cee3
https://doi.org/10.1016/j.drudis.2011.12.020
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6
Nonpeptide Luteinizing Hormone-Releasing Hormone Antagonists Derived from Erythromycin A: Design, Synthesis, and Biological Activity of Cladinose Replacement Analogues
Autor: Daryl R. Sauer, Jonathan Greer, Charles J. Nichols, Craig D. Wegner, Jason A. Segreti, Kurt M. Mohning, Fortuna Haviv, John T. Randolph, E N Bush, Philip L. Waid, Gilbert Diaz, Leslie M. Besecke, Gary Bammert
Publikováno v: Journal of Medicinal Chemistry. 47:1085-1097
The design and synthesis of a series of 11,12-cyclic carbamate derivatives of 6-O-methylerythromycin A that are novel, nonpeptide LHRH antagonists, is described. The macrolide antagonist 1, discovered during a screen of our chemical repository, was c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fabef2f09ac213c5e8373f774e466e4
https://doi.org/10.1021/jm030418i
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7
Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion
Autor: James D. Crapo, Nathan L. Lubbers, Bryan F. Cox, James S. Polakowski, Craig D. Wegner
Publikováno v: Journal of Cardiovascular Pharmacology. 41:714-719
Reactive oxygen species (ROS) have been implicated as important mediators of cellular damage during ischemia/reperfusion. AEOL10113 is a low-molecular-weight superoxide dismutase mimetic that has dismutase activity against ROS. The objective of this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68a1bad6ccfcbb46e3e5753d8727128
https://doi.org/10.1097/00005344-200305000-00007
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8
Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats
Autor: James S. Polakowski, Nathan L. Lubbers, Sandra E. Burke, Katina M Daniell, Bryan F. Cox, Craig D. Wegner, Gilbert Diaz
Publikováno v: European Journal of Pharmacology. 435:79-83
Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral pretreatment of rats with bimoclomol could elevate myocardial HSP70 and reduce infarct siz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b78ac2bcba8f49cc9f88e5bf2b58b4
https://doi.org/10.1016/s0014-2999(01)01552-7
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Pharmacological and endocrine characterization of A-198401, an orally active GnRH antagonist, in intact and castrate male rat models
Autor: Kurt M. Mohning, E N Bush, Van A. Cybulski, Craig D. Wegner, Gilbert Diaz, Randolph John, Mira Rao, Jason A. Segreti, Jonathan Greer, Fortuna Haviv, Philip L. Waid, Leslie M. Besecke
Publikováno v: Drug Development Research. 52:485-491
Gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of the gonadotropins that maintain the reproductive axis in mammals. Efforts have focused on the characterization of novel, nonpeptidic orally active antagonists of the GnRH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34863a63a9805da58bf9feed4e71ffc9
https://doi.org/10.1002/ddr.1150
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10
Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys
Autor: Robert Rothlein, Ruth J. McDonald, Dallas M. Hyde, Charles G. Plopper, Craig D. Wegner, Viviana Wong, Kent E. Pinkerton, Lisa A. Miller, Mary Y. Stovall
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L1190-L1198
To test the hypothesis that neutrophil influx is important for the removal of necrotic airway epithelial cells, rhesus monkeys were treated with a function-blocking monoclonal antibody (MAb) against CD18 followed by exposure to ozone or filtered air.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1415a4a64d43cff77e9fdf2df3ce117d
https://doi.org/10.1152/ajplung.1999.277.6.l1190
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