Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Craig C. Malbon"'
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2503 (2008)
BackgroundMice deficient in apolipoprotein E (apoE(-/-)) develop atherosclerosis. The possible linkage between expression of adhesion molecules/cofactors and atherosclerosis was probed at the level of mRNA and protein expression. The hypothesis of a
Externí odkaz:
https://doaj.org/article/310ba749fe6b44a083bf4870d55fa14c
Autor:
Craig C. Malbon
In 21st century America, personhood is under daily assault, sometimes with dire consequences. Scientist, ethicist, and ordained minister Craig C. Malbon encourages the reader to consider such assaults on personhood endured by victims of abortion, age
Publikováno v:
Journal of Molecular Signaling
Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modulate the blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054b64eee3e4535a704e66aa20d54148
https://pubmed.ncbi.nlm.nih.gov/27096003
https://pubmed.ncbi.nlm.nih.gov/27096003
Publikováno v:
Journal of Molecular Signaling; Vol 11 (2016); 1
Journal of Molecular Signaling
Journal of Molecular Signaling
The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7be53dbb36f653dc35055b1637d7834
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-11-1
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-11-1
Publikováno v:
Journal of Cell Science
Wnt/β-catenin signaling is essential for normal mammalian development. Wnt3a activates the Wnt/β-catenin pathway through stabilization of β-catenin; a process in which the phosphoprotein Dishevelled figures prominently. Protein arginine methylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9cf5fba5357120341b6d36e37ff688
https://doi.org/10.1242/jcs.084046
https://doi.org/10.1242/jcs.084046
Autor:
Hsien-yu Wang, Craig C. Malbon
Publikováno v:
Acta Physiologica. 204:65-73
The phosphoprotein scaffold Dishevelled is an essential component of both Wnt signalling and of the signalsome that constitutes the supermolecular 'punctae' of assembled proteins often observed in fluorescence microscopy. The C-terminal region beyond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ea8b295ccab129239408c527e79089
https://doi.org/10.1111/j.1748-1716.2011.02291.x
https://doi.org/10.1111/j.1748-1716.2011.02291.x
Publikováno v:
Journal of Cell Science. 123:3693-3702
Dishevelled-3 (Dvl3) is a multivalent scaffold protein that is essential to Wnt signaling during development. Although Dvl-based punctae have been visualized by fluorescence microscopy; the physical nature and dynamic character of the such complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4017a990a5c7c4f0b783aa79745a714
https://doi.org/10.1242/jcs.075275
https://doi.org/10.1242/jcs.075275
Autor:
Min-Huei Chen, Craig C. Malbon
Publikováno v:
Cellular Signalling. 21:136-142
A-kinase Anchoring Proteins (AKAPs) define an expanding group of scaffold proteins that display a signature binding site for the RI/RII subunit of protein kinase A. AKAP5 and AKAP12 are multivalent (with respect to protein kinases and phosphatases) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252f6f151c2c51f6546d731202d92315
https://doi.org/10.1016/j.cellsig.2008.09.019
https://doi.org/10.1016/j.cellsig.2008.09.019
Publikováno v:
Journal of Cell Science. 121:3598-3607
The Wnt-beta-catenin canonical signaling pathway is crucial for normal embryonic development, and aberrant expression of components of this pathway results in oncogenesis. Upon scanning for the mitogen-activated protein kinase (MAPK) pathways that mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4b4796e0e25536f07864b7d1569b75
https://doi.org/10.1242/jcs.032854
https://doi.org/10.1242/jcs.032854