Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Craig C Garner"'
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterised by deficits in social interactions and repetitive behaviours. ASDs have a strong genetic basis with mutations involved in the development and function of neural
Externí odkaz:
https://doaj.org/article/fb2d8025094f4a159c63dedd047e609d
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiological tasks
Externí odkaz:
https://doaj.org/article/bbd43f596fb54ca9a8133a9e5ed0b10d
Autor:
Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 7, Pp 1-20 (2018)
Abstract Information on protein–protein interactions (PPIs) is of critical importance for studying complex biological systems and developing therapeutic strategies. Here, we present a double‐readout bioluminescence‐based two‐hybrid technology
Externí odkaz:
https://doaj.org/article/6a2435b9498b4222843c1f79d478cf6f
Autor:
Ewa Andrzejak, Eshed Rabinovitch, Jakob Kreye, Harald Prüss, Christian Rosenmund, Noam E. Ziv, Craig C. Garner, Frauke Ackermann
Publikováno v:
The journal of neuroscience 42(15), 3253-3270 (2022). doi:10.1523/JNEUROSCI.1689-21.2022
Anti-NMDA receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder associated with autoantibodies against NMDARs, which cause a variety of symptoms from prominent psychiatric and cognitive manifestations to seizures and autonomic instabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59f1b586e238fd2de33f5398f3afa2d
https://doi.org/10.1523/jneurosci.1689-21.2022
https://doi.org/10.1523/jneurosci.1689-21.2022
Autor:
Kazi Atikur Rahman, Marta Orlando, Ayub Boulos, Ewa Andrzejak, Dietmar Schmitz, Noam E. Ziv, Harald Prüss, Craig C. Garner, Aleksandra Ichkova
Publikováno v:
Glia 71(8), 1804-1829 (2023). doi:10.1002/glia.24369
Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization-mediated loss of NMDARs is thought to be the major m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d8d6f8e0d34ad5737928bf90219510
Autor:
Susann Michanski, Rohan Kapoor, Anna M. Steyer, Wiebke Möbius, Iris Früholz, Frauke Ackermann, Mehmet Gültas, Craig C. Garner, F. Kent Hamra, Jakob Neef, Nicola Strenzke, Tobias Moser, Carolin Wichmann
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e490193e2a19496dcc0b87673caf36
https://doi.org/10.1101/2022.12.15.520589
https://doi.org/10.1101/2022.12.15.520589
Autor:
Huong T. T. Ha, Sergio Leal-Ortiz, Kriti Lalwani, Shigeki Kiyonaka, Itaru Hamachi, Shreesh P. Mysore, Johanna M. Montgomery, Craig C. Garner, John R. Huguenard, Sally A. Kim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
During development, pyramidal neurons undergo dynamic regulation of AMPA receptor (AMPAR) subunit composition and density to help drive synaptic plasticity and maturation. These normal developmental changes in AMPARs are particularly vulnerable to ri
Externí odkaz:
https://doaj.org/article/95f494fd563543b49d09449d0553c14b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The SHANK family of synaptic proteins (SHANK1–3) are master regulators of the organizational structure of excitatory synapses in the brain. Mutations in SHANK1–3 are prevalent in patients with autism spectrum disorders (ASD), and loss of one copy
Externí odkaz:
https://doaj.org/article/a2fbc82f6069460ba9ccc4159f04dc87
Autor:
Adriana C M, van Casteren, Frauke, Ackermann, Kazi Atikur, Rahman, Ewa, Andrzejak, Christian, Rosenmund, Jakob, Kreye, Harald, Prüss, Craig C, Garner, Aleksandra, Ichkova
Publikováno v:
eNeuro. 9(6)
Autoantibodies against central nervous system proteins are increasingly being recognized in association with neurologic disorders. Although a growing number of neural autoantibodies have been identified, a causal link between specific autoantibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fbd30e817f1f7f742a99b5dbc114b0
https://pubmed.ncbi.nlm.nih.gov/36446572
https://pubmed.ncbi.nlm.nih.gov/36446572
Autor:
Duxan Arancibia, Matias Lira, Yocelin Cruz, Daniela P. Barrera, Carolina Montenegro-Venegas, Juan A. Godoy, Craig C. Garner, Nibaldo C. Inestrosa, Eckart D. Gundelfinger, Pedro Zamorano, Viviana I. Torres
Publikováno v:
Cells, Vol 8, Iss 11, p 1333 (2019)
Neurons release neurotransmitters at a specialized region of the presynaptic membrane, the active zone (AZ), where a complex meshwork of proteins organizes the release apparatus. The formation of this proteinaceous cytomatrix at the AZ (CAZ) depends
Externí odkaz:
https://doaj.org/article/7ce464c8c8164ed3bf38d51da2923b2b