Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Craig B Wilen"'
Autor:
Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011351 (2023)
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including
Externí odkaz:
https://doaj.org/article/96107a75fb7e477fb76c01fbddef0ecf
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Autor:
Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G Doench, Patrick D Hsu, Cigall Kadoch, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002097 (2023)
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We previously performed a genome-wi
Externí odkaz:
https://doaj.org/article/c10dd58b10dd439eb9610eccf28fbb91
Autor:
Jaewon Song, Ryan D Chow, Mario A Peña-Hernández, Li Zhang, Skylar A Loeb, Eui-Young So, Olin D Liang, Ping Ren, Sidi Chen, Craig B Wilen, Sanghyun Lee
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001805 (2022)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors and coreceptors facilitating entry are extensively studied, cellular entry fa
Externí odkaz:
https://doaj.org/article/9ca0a77538664cbb885e8018fda703f5
Autor:
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A Mainou, Robert C Orchard, Craig B Wilen, Pamela H Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S Dermody
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010322 (2022)
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficki
Externí odkaz:
https://doaj.org/article/9a120a5913574c848a92d601c03ff421
Autor:
Madison S Strine, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010318 (2022)
Although tuft cells were discovered over 60 years ago, their functions have long been enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key orchestrators of the host response to diverse microbial infections in th
Externí odkaz:
https://doaj.org/article/7b31f85a08524d38b080bc02f5245c92
Autor:
Neal G Ravindra, Mia Madel Alfajaro, Victor Gasque, Nicholas C Huston, Han Wan, Klara Szigeti-Buck, Yuki Yasumoto, Allison M Greaney, Victoria Habet, Ryan D Chow, Jennifer S Chen, Jin Wei, Renata B Filler, Bao Wang, Guilin Wang, Laura E Niklason, Ruth R Montgomery, Stephanie C Eisenbarth, Sidi Chen, Adam Williams, Akiko Iwasaki, Tamas L Horvath, Ellen F Foxman, Richard W Pierce, Anna Marie Pyle, David van Dijk, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001143 (2021)
There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19). Enhanced understanding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Externí odkaz:
https://doaj.org/article/953d8b25aa2b462bb1a23148fd6012d7
Autor:
Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Externí odkaz:
https://doaj.org/article/90fb07bf8a2e40fb883cfc49c1867b66
Autor:
Vincent R Graziano, Forrest C Walker, Elizabeth A Kennedy, Jin Wei, Khalil Ettayebi, Madison S Strine, Renata B Filler, Ebrahim Hassan, Leon L Hsieh, Arthur S Kim, Abimbola O Kolawole, Christiane E Wobus, Lisa C Lindesmith, Ralph S Baric, Mary K Estes, Robert C Orchard, Megan T Baldridge, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008242 (2020)
Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unkn
Externí odkaz:
https://doaj.org/article/c2674dd032554c20845ee5f10d202eda
Autor:
Myra Hosmillo, Jia Lu, Michael R McAllaster, James B Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J Fitzmaurice, Matthew KH Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B Wilen, Ian G Goodfellow
Publikováno v:
eLife, Vol 8 (2019)
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR scr
Externí odkaz:
https://doaj.org/article/b363fd3bd210419ea316195ab964dab9
Autor:
Josiah Petersen, Mary Jane Drake, Emily A Bruce, Amber M Riblett, Chukwuka A Didigu, Craig B Wilen, Nirav Malani, Frances Male, Fang-Hua Lee, Frederic D Bushman, Sara Cherry, Robert W Doms, Paul Bates, Kenneth Briley
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003911 (2014)
The Bunyaviridae comprise a large family of RNA viruses with worldwide distribution and includes the pathogenic New World hantavirus, Andes virus (ANDV). Host factors needed for hantavirus entry remain largely enigmatic and therapeutics are unavailab
Externí odkaz:
https://doaj.org/article/f0959b3fb26345a8ad77874cb23e408f