Zobrazeno 1 - 10
of 538
pro vyhledávání: '"Craig A. Simmons"'
Autor:
Jennifer C.-Y. Chung, MD, MSc, Daniella Eliathamby, MASc, Hijun Seo, MASc, Chun-Po Fan, PhD, Rifat Islam, MD, MSc, Karamvir Deol, RN, Craig A. Simmons, PhD, Maral Ouzounian, MD, PhD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 38-47 (2023)
Background: Although aneurysms of the ascending aorta and the aortic root are treated similarly in clinical guidelines, how biomechanical properties differ between these 2 segments of aorta is poorly defined. Methods: Biomechanical testing was perfor
Externí odkaz:
https://doaj.org/article/8764f097258e42349ca77f9151cebec0
Autor:
Shouka Parvin Nejad, Monica Lecce, Bahram Mirani, Nataly Machado Siqueira, Zahra Mirzaei, J. Paul Santerre, John E. Davies, Craig A. Simmons
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Constructs currently used to repair or replace congenitally diseased pediatric heart valves lack a viable cell population capable of functional adaptation in situ, necessitating repeated surgical intervention. Heart valve tissue e
Externí odkaz:
https://doaj.org/article/58034ec1dad34fc1b8cfdcb260ce57c2
Autor:
Daniella Eliathamby, BEng, Melanie Keshishi, BHSc, MBDC, Maral Ouzounian, MD, PhD, Thomas L. Forbes, MD, Kongteng Tan, MD, Craig A. Simmons, PhD, Peng, Jennifer Chung, MD, MSc
Publikováno v:
JTCVS Open, Vol 13, Iss , Pp 32-44 (2023)
Objective: The objective of this study was to evaluate the relationship between ascending aortic geometry and biomechanical properties. Methods: Preoperative computed tomography scans from ascending aortic aneurysm patients were analyzed using a cent
Externí odkaz:
https://doaj.org/article/d198d07d35624eefbc7978a21fcd6750
Autor:
Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop
Externí odkaz:
https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34
Autor:
Neal I. Callaghan, Lauren J. Durland, Ronald G. Ireland, J. Paul Santerre, Craig A. Simmons, Locke Davenport Huyer
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-25 (2022)
Abstract The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise for basic science, drug testing, disease modeling, personalized medicine, and translatable cell therapies across many tissue types. However, in practic
Externí odkaz:
https://doaj.org/article/a9983e6cae9d46ba83d7a5e678f0381c
Autor:
Wenkun Dou, Manpreet Malhi, Qili Zhao, Li Wang, Zongjie Huang, Junhui Law, Na Liu, Craig A. Simmons, Jason T. Maynes, Yu Sun
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug cardiotoxicity as well as for therapeutic discovery. Challenges still
Externí odkaz:
https://doaj.org/article/b2912b925d9f4854b960c422a74ee37d
Autor:
Jeremy A. Antonyshyn, Vienna Mazzoli, Meghan J. McFadden, Anthony O. Gramolini, Stefan O. P. Hofer, Craig A. Simmons, J. Paul Santerre
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Antonyshyn et al. establish a methodology for acquiring human adipose tissue-derived microvascular endothelial cells that can be readily applied in future vascular tissue engineering applications. The authors developed strategies to mitigate the non-
Externí odkaz:
https://doaj.org/article/1f3a0bde7e2840cba941ac6669c4daa6
Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?
Publikováno v:
JTCVS Open, Vol 10, Iss , Pp 123-124 (2022)
Externí odkaz:
https://doaj.org/article/ca3c1a36cc254e4397375ce4deefdb9b
Autor:
Shahrin Islam, Kristina I. Boström, Dino Di Carlo, Craig A. Simmons, Yin Tintut, Yucheng Yao, Jeffrey J. Hsu
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Endothelial cells (ECs) lining the cardiovascular system are subjected to a highly dynamic microenvironment resulting from pulsatile pressure and circulating blood flow. Endothelial cells are remarkably sensitive to these forces, which are transduced
Externí odkaz:
https://doaj.org/article/40f73fe5098f4e64b8292f2ec747c7bc
Autor:
Jennifer C.‐Y. Chung, Edwin Wong, Mingyi Tang, Daniella Eliathamby, Thomas L. Forbes, Jagdish Butany, Craig A. Simmons, Maral Ouzounian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 15 (2020)
Background Current methods for aortic dissection risk assessment are inadequate for patients with ascending aortic aneurysms associated with either bicuspid aortic valves (BAVs) or tricuspid aortic valves (TAVs). Biomechanical testing of aortic tissu
Externí odkaz:
https://doaj.org/article/054d897dedf2403e9e34ba264fc5b993