Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Craig A. Lygate"'
Autor:
Mahon L. Maguire, Debra J. McAndrew, Hannah A. Lake, Philip J. Ostrowski, Sevasti Zervou, Stefan Neubauer, Craig A. Lygate, Jurgen E. Schneider
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-10 (2023)
Abstract Background Phosphorus cardiovascular magnetic resonance spectroscopy (31P-CMRS) has emerged as an important tool for the preclinical assessment of myocardial energetics in vivo. However, the high rate and diminutive size of the mouse heart i
Externí odkaz:
https://doaj.org/article/2f14a28b965446bc9091be7fea4b46e5
Autor:
Debra J. McAndrew, Hannah A. Lake, Sevasti Zervou, Edzard Schwedhelm, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
ESC Heart Failure, Vol 10, Iss 1, Pp 189-199 (2023)
Abstract Aims Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT),
Externí odkaz:
https://doaj.org/article/691f3e52900d4fff9ed09158b3da5d5c
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels
Externí odkaz:
https://doaj.org/article/94023c0bcce0442ab38a3695e1f0cc4f
Autor:
Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In order to fully understand gene function, at some point, it is necessary to study the effects in an intact organism. The creation of the first knockout mouse in the late 1980’s gave rise to a revolution in the field of integrative physiology that
Externí odkaz:
https://doaj.org/article/5b1943ab3f524f84aa2994f442ae4568
Autor:
Sevasti Zervou, Debra J. McAndrew, Hannah J. Whittington, Hannah A. Lake, Kyung Chan Park, Kuan Minn Cha, Philip J. Ostrowski, Thomas R. Eykyn, Jürgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
AimsAdenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We hypothesised that increased AK1 activity would have negligible effects at rest, but protect
Externí odkaz:
https://doaj.org/article/4987ce7164ec4b948b413bb6efbed548
Autor:
Dunja Aksentijević, Sevasti Zervou, Thomas R. Eykyn, Debra J. McAndrew, Julie Wallis, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart
Externí odkaz:
https://doaj.org/article/a17d9c8f7cff4d13bb919761852314e7
Autor:
Malte Stockebrand, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis. Subseque
Externí odkaz:
https://doaj.org/article/80d7c7fb74354e779da9990f12cd48c5
Autor:
Shveta Monga, Ladislav Valkovič, Damian Tyler, Craig A. Lygate, Oliver Rider, Saul G. Myerson, Stefan Neubauer, Masliza Mahmod
Publikováno v:
JACC: Cardiovascular Imaging. 15:2112-2126
Pressure overload in aortic stenosis (AS) encompasses both structural and metabolic remodeling and increases the risk of decompensation into heart failure. A major component of metabolic derangement in AS is abnormal cardiac substrate use, with down-
Autor:
Katrin Nitz, Michael Lacy, Mariaelvy Bianchini, Kanin Wichapong, Irem Avcilar Kücükgöze, Cecilia A. Bonfiglio, Roberta Migheli, Yuting Wu, Carina Burger, Yuanfang Li, Ignasi Forné, Constantin Ammar, Aleksandar Janjic, Sarajo Mohanta, Johan Duchene, Johan W.M. Heemskerk, Remco T.A. Megens, Edzard Schwedhelm, Stephan Huveneers, Craig A. Lygate, Donato Santovito, Ralf Zimmer, Axel Imhof, Christian Weber, Esther Lutgens, Dorothee Atzler
Publikováno v:
Circulation research, 131(8), 701-712. Lippincott Williams and Wilkins
Circulation Research, 131(8), 701-712. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 131(8), 701-712. LIPPINCOTT WILLIAMS & WILKINS
Background: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid homoarginine is a robust biomarker for cardiovascular outcome and mortality with high levels being protective. However, the underl
Autor:
Adrian L. Harris, Benedikt M. Kessler, Craig A. Lygate, Sevasti Zervou, Hannah A. Lake, Hannah J. Whittington, Oscar Yanes, Miguel Rodriguez, Dilair Baban, Francesca M. Buffa, Syed Haider, Esther Bridges, Alan McIntyre, Martin Frejno, Roman Fischer, Katharina Feldinger, Tomoyoshi Soga, Patrick K. Albers, Christos E. Zois, Matteo Morotti, Alessandro Valli
S3. HIF1α and hypoxia-dependent effects on transcription and protein levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d37bd4b9cbd85ee8251787d7b3404c
https://doi.org/10.1158/1541-7786.22515507
https://doi.org/10.1158/1541-7786.22515507