Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Craig A. Henke"'
Autor:
Libang Yang, Adam Gilbertsen, Hong Xia, Alexey Benyumov, Karen Smith, Jeremy Herrera, Emil Racila, Peter B. Bitterman, Craig A. Henke
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Hypoxia is a sentinel feature of idiopathic pulmonary fibrosis (IPF). The IPF microenvironment contains high lactate levels, and hypoxia enhances cellular lactate production. Lactate, acting through the GPR81 lactate receptor, serves as a signal mole
Externí odkaz:
https://doaj.org/article/3154f58106d74c148d746f3dce91fdab
Autor:
Libang Yang, Jianbo Yang, Blake Jacobson, Adam Gilbertsen, Karen Smith, LeeAnn Higgins, Candace Guerrero, Hong Xia, Craig A. Henke, Jizhen Lin
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Mesenchymal stem cells (MSCs) contribute to tumor pathogenesis and elicit antitumor immune responses in tumor microenvironments. Nuclear proteins might be the main players in these processes. In the current study, combining spatial proteomics with in
Externí odkaz:
https://doaj.org/article/4cb1dd71837f4a9fb5ac9fec39d0068e
Autor:
Libang Yang, Hong Xia, Karen Smith, Adam Gilbertsen, Daniel Beisang, Jonathan Kuo, Peter B. Bitterman, Craig A. Henke
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. We previously identified fibrogenic mesenchymal progenitor cells (MPCs) in the lungs of patients with IPF who serve as drivers of progressive fibrosis. Recent single-cell RNA
Externí odkaz:
https://doaj.org/article/e5202f9518134fa193ed10cf1c380cf6
Autor:
Libang Yang, Hong Xia, Adam Gilbertsen, Karen Smith, Emil Racila, Peter B. Bitterman, Craig A. Henke
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L849-L862
Here we show that IL-8 concurrently promotes senescence and upregulation of PD-L1 in IPF MPCs. IHC analysis identifies the presence of senescent IPF MPCs intermingled with NK cells in the fibroblastic focus, suggesting that senescent MPCs elude immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a22aae83d5f61086f47e278ee51c2d3
https://doi.org/10.1152/ajplung.00028.2023
https://doi.org/10.1152/ajplung.00028.2023
Autor:
Hong Xia, Alexey Benyumov, Craig A. Henke, Peter B. Bitterman, Jeremy Herrera, Libang Yang, Emilian Racila, Karen Smith, Adam J Gilbertsen
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Despite modest improvement in patient outcomes from recent advances in pharmacotherapy targeting fibrogenic signaling pathways, idiopathic pulmonary fibrosis (IPF) remains a major unsolved clinical problem. One reason for this is that available antif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d61b27e1839ff838c9a5e77a4772b64
https://doi.org/10.1152/ajplung.00456.2020
https://doi.org/10.1152/ajplung.00456.2020
Autor:
Libang Yang, Adam Gilbertsen, Karen Smith, Hong Xia, LeeAnn Higgins, Candace Guerrero, Craig A. Henke
Publikováno v:
Proteomics. 22(13-14)
IPF is a progressive fibrotic lung disease whose pathogenesis remains incompletely understood. We have previously discovered pathologic mesenchymal progenitor cells (MPCs) in the lungs of IPF patients. IPF MPCs display a distinct transcriptome and cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186efa979c4aac2564b855bfce4b4a1f
https://pubmed.ncbi.nlm.nih.gov/35633524
https://pubmed.ncbi.nlm.nih.gov/35633524
Autor:
Adam J Gilbertsen, Hong Xia, Libang Yang, Craig A. Henke, Karen Smith, Daniel Beisang, Jonathan Kuo, Peter B. Bitterman
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight, Vol 6, Iss 9 (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. We previously identified fibrogenic mesenchymal progenitor cells (MPCs) in the lungs of patients with IPF who serve as drivers of progressive fibrosis. Recent single-cell RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dcfe640fb45c9d438e58c5e564c5b5
https://doi.org/10.1172/jci.insight.144652
https://doi.org/10.1172/jci.insight.144652
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61017 (2013)
Idiopathic Pulmonary Fibrosis is a lethal fibrotic disease characterized by the unrelenting proliferation and persistence of fibroblasts in a type I collagen-rich matrix that result in an expanding reticular network of fibrotic tissue. However, the u
Externí odkaz:
https://doaj.org/article/82b7b17e6bc041ba9395f315f88ec1f4
Autor:
Libang Yang, Brian J Sandri, Daniel Beisang, Jeremy Herrera, Alexey Benyumov, Eric F. Lock, Karen Smith, Adam J Gilbertsen, Emilian Racila, Craig A. Henke, Colleen L. Forster, Peter B. Bitterman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
In Idiopathic Pulmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft models. To determine where along their differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66755c0c5a7977ca000b9c8e84d5880
http://europepmc.org/articles/PMC7341888
http://europepmc.org/articles/PMC7341888
Autor:
Karen Smith, Libang Yang, Hong Xia, Peter B. Bitterman, S. Khalil, Adam J Gilbertsen, Craig A. Henke
Publikováno v:
D109. MODULATING THE FIBROTIC RESPONSE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66f67990ffba4421fb846b612498dc0b
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7877
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7877