Výsledky vyhledávání - "Craig A Smibert"

Akademický článek

Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.

Autor: Sabine Mohr, Andrew Kenny, Simon T Y Lam, Miles B Morgan, Craig A Smibert, Howard D Lipshitz, Paul M Macdonald

Publikováno v: PLoS Genetics, Vol 17, Iss 4, p e1009500 (2021)

Localization of oskar mRNA includes two distinct phases: transport from nurse cells to the oocyte, a process typically accompanied by cortical anchoring in the oocyte, followed by posterior localization within the oocyte. Signals within the oskar 3'

Externí odkaz: https://doaj.org/article/b36af49f94754b4aa2bb7332b8ed32bb

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Akademický článek

RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.

Autor: Qingtang Shen, Yifan E Wang, Mathew Truong, Kohila Mahadevan, Jingze J Wu, Hui Zhang, Jiawei Li, Harrison W Smith, Craig A Smibert, Alexander F Palazzo

Publikováno v: PLoS Genetics, Vol 17, Iss 2, p e1009378 (2021)

Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the overproduction of acute necrotizing encephalopathy (ANE1)-associated cytokines. Here we report that Ran

Externí odkaz: https://doaj.org/article/b93f08f948f04a9fb584b70576baef0e

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Akademický článek

ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

Autor: Miranda Wang, Michael Ly, Andrew Lugowski, John D Laver, Howard D Lipshitz, Craig A Smibert, Olivia S Rissland

Publikováno v: eLife, Vol 6 (2017)

In animal embryos, control of development is passed from exclusively maternal gene products to those encoded by the embryonic genome in a process referred to as the maternal-to-zygotic transition (MZT). We show that the RNA-binding protein, ME31B, bi

Externí odkaz: https://doaj.org/article/eaede19c8aa14e899a9a1fb0f6b75940

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Akademický článek

The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay.

Autor: Laura M Rendl, Melissa A Bieman, Heli K Vari, Craig A Smibert

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47121 (2012)

Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S. cerevisiae member of the Smaug family of RNA binding proteins, is

Externí odkaz: https://doaj.org/article/d7c3ffe5155142fd848d5f732e19c6e9

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Akademický článek

The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs

Autor: John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz

Publikováno v: Cell Reports, Vol 30, Iss 10, Pp 3353-3367.e7 (2020)

Summary: G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray anal

Externí odkaz: https://doaj.org/article/9faf1f277a61420f88079b33d872a60a

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Akademický článek

The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes

Autor: Olivia S. Rissland, Alexander O. Subtelny, Miranda Wang, Andrew Lugowski, Beth Nicholson, John D. Laver, Sachdev S. Sidhu, Craig A. Smibert, Howard D. Lipshitz, David P. Bartel

Publikováno v: Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)

Abstract Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-

Externí odkaz: https://doaj.org/article/d95ae799118d42feb5cbf376b05785f8

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Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing theoskarandbruno 1mRNAs

Autor: Najeeb U. Siddiqui, Angelo Karaiskakis, Aaron L. Goldman, Whitby V.I. Eagle, Craig A. Smibert, Elizabeth R. Gavis, Howard D. Lipshitz

During Drosophila oogenesis, the Oskar (OSK) RNA-binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here we identify the mechanisms that regulate theoskmRNA in the early embryo. We show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f26ab4f3861c4ee980cd813607d575b6
https://doi.org/10.1101/2023.02.27.530189