Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

Autor: Sevasti Zervou, Hannah J Whittington, Philip J Ostrowski, Fang Cao, Jack Tyler, Hannah A Lake, Stefan Neubauer, Craig A Lygate

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182994 (2017)

The creatine kinase (CK) phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro

Externí odkaz: https://doaj.org/article/a4faef99ab7448fd83a6dd79b79440e0

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.

Autor: Dunja Aksentijević, Sevasti Zervou, Kiterie M E Faller, Debra J McAndrew, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109021 (2014)

Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the

Externí odkaz: https://doaj.org/article/f1546b6aa1074079ba65d4d5420ba05b

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Autor: Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T Neil Dear

Publikováno v: PLoS Genetics, Vol 6, Iss 6, p e1001000 (2010)

Mutations in a number of genes have been linked to inherited dilated cardiomyopathy (DCM). However, such mutations account for only a small proportion of the clinical cases emphasising the need for alternative discovery approaches to uncovering novel

Externí odkaz: https://doaj.org/article/cf53f2f145ef4de89e57e33888a3702d

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure

Autor: Debra J. McAndrew, Hannah A. Lake, Sevasti Zervou, Edzard Schwedhelm, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate

Publikováno v: ESC Heart Failure, Vol 10, Iss 1, Pp 189-199 (2023)

Abstract Aims Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT),

Externí odkaz: https://doaj.org/article/691f3e52900d4fff9ed09158b3da5d5c

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

Autor: Katrin Nitz, Michael Lacy, Mariaelvy Bianchini, Kanin Wichapong, Irem Avcilar Kücükgöze, Cecilia A. Bonfiglio, Roberta Migheli, Yuting Wu, Carina Burger, Yuanfang Li, Ignasi Forné, Constantin Ammar, Aleksandar Janjic, Sarajo Mohanta, Johan Duchene, Johan W.M. Heemskerk, Remco T.A. Megens, Edzard Schwedhelm, Stephan Huveneers, Craig A. Lygate, Donato Santovito, Ralf Zimmer, Axel Imhof, Christian Weber, Esther Lutgens, Dorothee Atzler

Publikováno v: Circulation research, 131(8), 701-712. Lippincott Williams and Wilkins
Circulation Research, 131(8), 701-712. LIPPINCOTT WILLIAMS & WILKINS

Background: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid homoarginine is a robust biomarker for cardiovascular outcome and mortality with high levels being protective. However, the underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642fc6b87cae0b8a00e5cf36ec8664f0
https://doi.org/10.1161/circresaha.122.321094