Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Craig Witherington"'
Publikováno v:
Antisense and Nucleic Acid Drug Development. 10:323-332
A small oligodeoxyribonucleotide derived from in vitro selection has been shown to be capable of efficient sequence-specific cleavage of RNA at purine-pyrimidine junctions. As the reaction readily takes place under simulated physiologic conditions, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd13b5d2971cc6da2154834b71679886
https://doi.org/10.1089/oli.1.2000.10.323
https://doi.org/10.1089/oli.1.2000.10.323
Autor:
Mary Margaret Gozar, Craig Witherington, Toby Passioura, Angela Lai, Laurent P. Rivory, Amber Goodchild, Andrew King
Publikováno v:
Oligonucleotides. 18(3)
We have previously shown that Dz13, a catalytic DNA molecule (DNAzyme) designed against c-jun, is cytotoxic to nonquiescent cells by a mechanism independent of c-jun mRNA cleavage. In this report, we evaluated programmed cell death (PCD) pathways in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6e4b16c6135b7bb24873fbbbfa4011
https://pubmed.ncbi.nlm.nih.gov/18699742
https://pubmed.ncbi.nlm.nih.gov/18699742
Autor:
Laurent P. Rivory, Amber Goodchild, Andrew King, Angela Lai, Donald J. Birkett, Craig Witherington, Carly Tucker, Mary Margaret Gozar
Publikováno v:
Oligonucleotides. 16(4)
DNAzymes are catalytic DNA molecules capable of cleaving RNA substrates and therefore constitute a possible gene-suppression technology. We examined whether the previously reported potency of a DNAzyme targeting c-jun (Dz13) could be improved with ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82ae22eaecb56b7b4307fc61a2b2b36
https://pubmed.ncbi.nlm.nih.gov/17155906
https://pubmed.ncbi.nlm.nih.gov/17155906
Publikováno v:
The Journal of biological chemistry. 274(24)
A small catalytic DNA molecule targeting c-myc RNA was found to be a potent inhibitor of smooth muscle cell (SMC) proliferation. The catalytic domain of this molecule was based on that previously derived by in vitro selection (Santoro, S. W., and Joy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a5045d9f819d84cdf27ca938440484
https://pubmed.ncbi.nlm.nih.gov/10358082
https://pubmed.ncbi.nlm.nih.gov/10358082
Publikováno v:
Nature biotechnology. 17(5)
A small catalytic DNA, known as the 10–23 DNA enzyme or deoxyribozyme, has been shown to efficiently hydrolyze RNA at purine-pyrimidine (R-Y) junctions in vitro. Although these potentially cleavable junctions are ubiquitous, they are often protecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85500747bb4a4d8166e61b1a9fb4344
https://pubmed.ncbi.nlm.nih.gov/10331790
https://pubmed.ncbi.nlm.nih.gov/10331790
Autor:
Geoff Symonds, Andrew Carr, Ron Penny, Li Wang, Craig Witherington, Andrew King, David A. Cooper, Wayne Gerlach, Lun-Quan Sun
Publikováno v:
Human gene therapy. 9(9)
A hammerhead ribozyme retroviral construct, denoted RRz2, targeting the coding region of the human immunodeficiency virus type 1 (HIV-1) tat gene, has shown itself to be effective in a range of test systems. Inhibition of the replication of HIV-1 III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4677a68f296aceee49d571c3f8a6196a
https://pubmed.ncbi.nlm.nih.gov/9650613
https://pubmed.ncbi.nlm.nih.gov/9650613
Autor:
Lun-Quan Sun, Li Wang, David Warrilow, Craig Witherington, Geoff Symonds, Janet L. Macpherson
Several hammerhead ribozymes targeted to different sites within the retroviral packaging (psi) sequences of the Moloney murine leukemia virus (Mo-MLV) and the human immunodeficiency virus type 1 (HIV-1) were designed and shown to cleave target RNA in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c99f54f70f57c2f5238d24a458dd3db
https://europepmc.org/articles/PMC44887/
https://europepmc.org/articles/PMC44887/
Autor:
Laurent Rivory, Carly Tucker, Andrew King, Angela Lai, Amber Goodchild, Craig Witherington, Mary Margaret Gozar, Donald J. Birkett
Publikováno v:
Oligonucleotides; Vol. 16 Issue 4, p297-312, 16p