Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Craig Beall"'
Autor:
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)
Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, inc
Externí odkaz:
https://doaj.org/article/6034f1d72e63418cb69e689338644a8d
Autor:
Ana M. Cruz, Katie M. Partridge, Yasaman Malekizadeh, Julia M. Vlachaki Walker, Paul G. Weightman Potter, Katherine R. Pye, Simon J. Shaw, Kate L. J. Ellacott, Craig Beall
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
AimWe evaluated the efficacy of a novel brain permeable “metformin-like” AMP-activated protein kinase activator, R481, in regulating glucose homeostasis.Materials and MethodsWe used glucose sensing hypothalamic GT1-7 neuronal cells and pancreatic
Externí odkaz:
https://doaj.org/article/f44879889ae04371b5abf856270d301a
Publikováno v:
Cells, Vol 11, Iss 21, p 3422 (2022)
Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute a
Externí odkaz:
https://doaj.org/article/29126711bddc4d2ab8c82c6d26c8075c
Autor:
Paul G. Weightman Potter, Sam J. Washer, Aaron R. Jeffries, Janet E. Holley, Nick J. Gutowski, Emma L. Dempster, Craig Beall
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Aims/hypothesisRecurrent hypoglycaemia (RH) is a major side-effect of intensive insulin therapy for people with diabetes. Changes in hypoglycaemia sensing by the brain contribute to the development of impaired counterregulatory responses to and aware
Externí odkaz:
https://doaj.org/article/c6c89ae5c7d94de0afbfc6a623caeb02
Autor:
Alastair J. MacDonald, Yu Hsuan Carol Yang, Ana Miguel Cruz, Craig Beall, Kate L. J. Ellacott
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Tight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between, internal organs including the gastrointestinal tract, pancreas, liver, and brain. Critically
Externí odkaz:
https://doaj.org/article/696b633cbb13409dacc67f80725f02be
Autor:
Ana Miguel Cruz, Craig Beall
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Saturated fatty acids such as palmitate contribute to the development of Type 2 Diabetes by reducing insulin sensitivity, increasing inflammation and potentially contributing to anabolic resistance. We hypothesized that palmitate-induced ATP release
Externí odkaz:
https://doaj.org/article/43da0c14e07d488c9d003dafd547866a
Recurrent hypoglycaemia, a common side-effect of insulin therapy in the treatment of type 1 diabetes, induces impaired glucose-sensing. Better understanding of how astrocytes, important non-neuronal cells in the brain, function in low glucose environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41df3d216d81faf31ba8f87a74749ca4
Autor:
Fiona E. Holmes, Alastair J. MacDonald, Anthony E. Pickering, Kate L. J. Ellacott, Craig Beall
Publikováno v:
Glia
A role for glial cells in brain circuits controlling feeding has begun to be identified with hypothalamic astrocyte signaling implicated in regulating energy homeostasis. The nucleus of the solitary tract (NTS), within the brainstem dorsal vagal comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b8659ae87136f36062af9c61e06ff0
https://doi.org/10.1002/glia.23774
https://doi.org/10.1002/glia.23774
The dorsal vagal complex (DVC) is a brainstem site regulating diverse aspects of physiology including food intake and blood glucose homeostasis. Astrocytes are purported to play an active role in regulating DVC function and, by extension, physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a023531d04963f3cdc9a830b6acc4b96
https://doi.org/10.1101/2021.12.15.472746
https://doi.org/10.1101/2021.12.15.472746