Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Craig, Stamp"'
Autor:
Craig Stamp, Anze Zupanic, Ashwin Sachdeva, Elizabeth A. Stoll, Daryl P. Shanley, John C. Mathers, Thomas B.L. Kirkwood, Rakesh Heer, Benjamin D. Simons, Doug M. Turnbull, Laura C. Greaves
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 166-173 (2018)
Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the predominant mode of SC self-renewal and the rate of SC replacement. Here we use age-related mitoc
Externí odkaz:
https://doaj.org/article/9bda2126e811423486831f94b1e0f2ba
Autor:
Johanna H.K. Kauppila, Holly L. Baines, Ana Bratic, Marie-Lune Simard, Christoph Freyer, Arnaud Mourier, Craig Stamp, Roberta Filograna, Nils-Göran Larsson, Laura C. Greaves, James B. Stewart
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2980-2990 (2016)
Mutations of mtDNA are an important cause of human disease, but few animal models exist. Because mammalian mitochondria cannot be transfected, the development of mice with pathogenic mtDNA mutations has been challenging, and the main strategy has the
Externí odkaz:
https://doaj.org/article/c9d60e6d715741ada477ce9887a88f10
Autor:
Anna L. M. Smith, Carla Bradshaw, Julia C. Whitehall, Craig Stamp, Laura C. Greaves, Douglass M. Turnbull, Elizabeth A. Stoll, David Houghton, Alasdair P. Blain
Publikováno v:
Aging Cell
One of the hallmarks of aging is an accumulation of cells with defects in oxidative phosphorylation (OXPHOS) due to mutations of mitochondrial DNA (mtDNA). Rapidly dividing tissues maintained by stem cells, such as the colonic epithelium, are particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d920318caac25221909869bf3afaf7c
https://doi.org/10.1111/acel.13321
https://doi.org/10.1111/acel.13321
Autor:
Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom, Laura C. Greaves
Publikováno v:
Nat Cancer
Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute to tumorigenesis remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8307dc672e870d72fe4e13a7b26978cb
https://pubmed.ncbi.nlm.nih.gov/35121898
https://pubmed.ncbi.nlm.nih.gov/35121898
Autor:
Douglass M. Turnbull, Benjamin D. Simons, Thomas B. L. Kirkwood, Daryl P. Shanley, Craig Stamp, John C. Mathers, Laura C. Greaves, Rakesh Heer, Elizabeth A. Stoll, Ashwin Sachdeva, Anze Zupanic
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 166-173 (2018)
EBioMedicine
EBioMedicine
Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the predominant mode of SC self-renewal and the rate of SC replacement. Here we use age-related mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ab40e3c63ddf69ccb0b04e2b6b0995
https://doi.org/10.1016/j.ebiom.2018.04.017
https://doi.org/10.1016/j.ebiom.2018.04.017
Autor:
Nils-Göran Larsson, Arnaud Mourier, Christoph Freyer, Ana Bratic, Roberta Filograna, Craig Stamp, Marie-Lune Simard, Johanna H.K. Kauppila, James B. Stewart, Holly L. Baines, Laura C. Greaves
Publikováno v:
Cell Reports
Cell Reports, Vol 16, Iss 11, Pp 2980-2990 (2016)
Cell Rep
Cell Reports, Vol 16, Iss 11, Pp 2980-2990 (2016)
Cell Rep
Summary Mutations of mtDNA are an important cause of human disease, but few animal models exist. Because mammalian mitochondria cannot be transfected, the development of mice with pathogenic mtDNA mutations has been challenging, and the main strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c824f6f9ee2b07b5edd40e78024257a
https://doi.org/10.1016/j.celrep.2016.08.037
https://doi.org/10.1016/j.celrep.2016.08.037
Autor:
Neil McGuiness, Craig Stamp, Mark R Dowling, Florian Mullershausen, Steven J. Charlton, Darren Riddy, Afrah Sattikar, David A. Sykes, Danilo Guerini, Ines Rodrigues, Michelle Bradley, Albrecht Glaenzel
Publikováno v:
British Journal of Pharmacology. 171:4797-4807
Background and Purpose The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1edb2ffc3a96566b0c3838b5631d9e
https://doi.org/10.1111/bph.12620
https://doi.org/10.1111/bph.12620
Publikováno v:
British Journal of Pharmacology. 167:868-880
BACKGROUND AND PURPOSE DiscoverRx's PathHunter™ assay measures GPCR agonist potency, via the recruitment of β-arrestin, independent of the subtype of Gα protein activated. This assay is frequently used in drug discovery although little is known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7384b507d88de4b31fbdb73eefcf5a0
https://doi.org/10.1111/j.1476-5381.2012.02032.x
https://doi.org/10.1111/j.1476-5381.2012.02032.x
Autor:
Holly L, Baines, James B, Stewart, Craig, Stamp, Anze, Zupanic, Thomas B L, Kirkwood, Nils-Göran, Larsson, Douglass M, Turnbull, Laura C, Greaves
Publikováno v:
Mechanisms of Ageing and Development
Highlights • Colonic crypts with mitochondrial dysfunction accumulate with age in PolgA+/mut mice. • Mitochondrial dysfunction is caused by clonally expanded mtDNA point mutations. • The mutations are random and their expansion is not subject t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6195e4282ca8686186c54a092e98c9d
https://pubmed.ncbi.nlm.nih.gov/24915468
https://pubmed.ncbi.nlm.nih.gov/24915468
Autor:
David A, Sykes, Darren M, Riddy, Craig, Stamp, Michelle E, Bradley, Neil, McGuiness, Afrah, Sattikar, Danilo, Guerini, Ines, Rodrigues, Albrecht, Glaenzel, Mark R, Dowling, Florian, Mullershausen, Steven J, Charlton
Publikováno v:
British journal of pharmacology. 171(21)
The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding kinetics and β-arresti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8242a0923714a73fea557d6fb0ed1101
https://pubmed.ncbi.nlm.nih.gov/24641481
https://pubmed.ncbi.nlm.nih.gov/24641481